Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

Hsu, Jonathan C.; Crawley, Suzanne C.; M, Chen; Da, Ayupova; Da, Lindhout; Higbee, Jared; Kutach, Alan K.; W, Joo; Fu, Deliang; C, To; Mondal, Kalyani; B, Li; Kekatpure, Avantika; Wang, M; Laird, Teresa; Horner, Geoffrey; Chan, Jim Yee Him; cEntee, M; López, Miguel; Lakshminarasimhan, Damodharan; White, Anna Marie; Sp, Wang; Yao, Jing; J, Yie; Matern, Hugo; Solloway, Mark J.; Haldankar, Raj; Parsons, Thomas B.; Tang, Jason X.; Wd, Shen; Y, Alice Chen; Tian, Hong; Bb, Allan

doi:10.1530/ey.15.15.8

Cited by 6 publications

(18 citation statements)

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“…These important results advocate for high dose LT4 treatment without adverse effects in adult life in accordance with a recent study from New Zealand 2 and the current ESPE guidelines. Concerns raised recently concerning worse intellectual outcome in CH patients at the age of 11 years after episodes of overtreatment during the first two years of life 3 were not confirmed in this study. Newborn screening (NBS) is an invaluable tool for identification of CH; however almost 70% of newborns worldwide do not benefit from NBS at all.…”

Section: Mean High-dose L-thyroxine Treatment Is Efficient and Safe Tcontrasting

confidence: 99%

“…This study sheds light on the long-term efficacy of GH treatment in PWS children by analysing data collected in the largest available international database. Although GH therapy was far less effective in stimulating growth than in non-PWS GHD subjects, these results confirm the effectiveness of this treatment in children with PWS leading to an average final height of −1.2 SDS, corresponding to 170 cm in males and 156 cm in girls, consistent with previous studies performed in smaller numbers [2][3][4]. GH was effective not only in increasing height but also in controlling the progression of obesity.…”

Section: Growth Hormone Treatment In Children With Prader-willi Syndrsupporting

confidence: 88%

“…However, the debate remains unsolved in the absence of high-quality evidence and in light of studies with contradictory results, e.g. on developmental outcome in infants with mildly elevated TSH at NBS 1,2,3 . All the authors agree on two further points: special attention should be given 1) to the iodine status of infants and mothers, and 2) to realize access to NBS programs and care for all newborns worldwide.…”

Section: Mean High-dose L-thyroxine Treatment Is Efficient and Safe Tmentioning

confidence: 99%

“…They have been termed KNDy neurons, because they produce kisspeptin, neurokinin B and dynorphin. The authors had previously shown that the secretory activity of KNDy neurons is kept in check during female prepubertal development by an epigenetic mechanism of transcriptional repression, exerted by the Polycomb group (PcG) of transcriptional silencers [1][2][3] . PcG proteins repress the Kiss1 gene to prevent the premature initiation of the pubertal process, and this effect takes place against a backdrop of repressive chromatin, that is, rich in histone modifications associated with gene repression and depleted of histone modifications associated with gene activation.…”

Section: Pubertymentioning

confidence: 99%

“…(2):649-659A minimum level of energy availability is required for the onset of puberty, whereas increased fat mass has been shown to be associated with precocious onset of puberty 1,2 . Recent genome-wide association studies have identified several loci for age at menarche also associated with obesity [3][4][5] . Whether such genes may regulate pubertal timing exclusively via impact on fat mass or via other body mass index (BMI)-independent mechanisms is unknown.…”

Section: Pubertymentioning

confidence: 99%

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Pituitary and Neuroendocrinology

de¹,

F²,

Gaston‐Massuet³

2018

ESPE

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The Yearbook of Paediatric Endocrinology counts years from June to June, when we submit the manuscripts to our publisher, and so much happened since June 2017. Our 13 Associate Editors and their coauthors do not take anything for granted and have once again done an enormous work to discern this year's advances. You will see that we cite papers on genomics and genetics, molecular biology and systems biology, evolutionary biology, clinical trials and medical reports to provide new insights in paediatric endocrinology, as the complexity of our field increases. Among other highlights, the Yearbook 2018 describes: new treatments (MC4R agonist for monogenic obesity; long-term outcomes of rhGH in chronic inflammatory disease; FGF23 antibody in children with XLH; oral GnRH antagonist), new genes (the CLCN2 chloride channel in primary hyperaldosteronism; genetic heterogeneity in T1DM; and new genes in severe obesity and hypogonadotrophic hypogonadism), new mechanisms (Stella insufficiency in oocytes induced by maternal obesity; noncanonical thyroid hormone receptor signalling; epigenetic control of puberty; hypothalamic stem cells control ageing speed; estrogen receptors and excess autoimmune disease in women) and other findings with important implications (consensus definition of fetal growth restriction in newborns; remission of childhood overweight on the risk of T2DM; the 'nocebo' effect; how your Pediatric Department can support Global Health). A growing number of included papers describe non-genetic inheritance (NGI). Transgenerational epigenetic inheritance is the form of NGI that has gained eminence: germline transmission of DNA methylation patterns, histone modification and small RNAs trigger the inheritance of traits, including child growth, puberty and development. But according to a new book by Russell Bonduriansky and Troy Day Extended Heredity: A New Understanding of Inheritance and Evolution (Princeton University Press), "Epigenetic inheritance is only the tip of the NGI iceberg." NGI also includes adaptive parental effects, social learning, the inherited microbiome, and structural inheritance in single-celled eukaryotes in predicting adaptive responses. In this Preface, we annually highlight a prize given in the field of endocrinology. Time and again, metabolic regulation attracts the highest accolades, and we salute Jeffrey Hall, Michael Rosbash, and Michael Young, recipients of the 2017 Nobel Prize for Physiology or Medicine, for their discoveries of molecular mechanisms controlling the biological clock. We also mark each year important science anniversaries: in 1918, L. Greving described the nervous connections between the hypothalamus and pituitary gland-a central dogma of endocrinology. Greving then discovered the tract of unmyelinated nerve fibers running down the neural stalk into the posterior pituitary. But 1918 was also the year of the Spanish flu, killing 50 million people, and World War I ended. Ninety-nine years later it was shown that these hardships in childhood were associated with worse ph...

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Section: Mean High-dose L-thyroxine Treatment Is Efficient and Safe Tcontrasting

confidence: 99%

Section: Growth Hormone Treatment In Children With Prader-willi Syndrsupporting

confidence: 88%

Section: Mean High-dose L-thyroxine Treatment Is Efficient and Safe Tmentioning

confidence: 99%

Section: Pubertymentioning

confidence: 99%

Section: Pubertymentioning

confidence: 99%

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