Non-Hodgkin's Lymphoma of the Knee: A Case Report

Lee, Ryan Ka Lok; Griffith, James F.; Ng, Alex Wing Hung; Tam, Hillary Ka Ying; Chan, Anthony W.H.

doi:10.5812/iranjradiol.7583

Cited by 4 publications

(3 citation statements)

References 18 publications

(30 reference statements)

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“…Among bony ALCL cases, common sites include the iliac bones [ 6 ], the sternum [ 7 ], the proximal femur [ 8 ], vertebrae, and ribs [ 9 , 10 , 11 ]. Primary non-Hodgkin’s lymphoma of the knee joint has also been reported, and in rare cases, it has been found to involve the synovium [ 12 ]. Cases of an ALCL primarily of the knee joint have not been observed.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Anaplastic Large Cell Lymphoma of the Knee Joint

Zade,

Rao,

Patil

et al. 2023

JOCR

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Introduction: Anaplastic large cell lymphoma (ALCL), which makes up only 2–5% of instances of NHL, is a rare and aggressive form of the disease. Anaplastic Lymphoma Kinase (ALK)-positive ALCL is a variant of the illness that is identified by the presence of an ALK gene fusion. The disease is most commonly confined to the nodes, but extranodal spread has been reported. Skin and soft tissue are the most frequently identified locations for extranodal involvement, while joints are extremely rare. We describe a rare case of ALCL affecting the knee joint that is ALK -positive. Case Report: A 51-year-old female presented with pain in her right knee. It was diagnosed as synovitis and treated accordingly. The symptoms did not relieve and a magnetic resonance imaging (MRI) scan was performed that indicated a meniscus tear. She was treated for it; however, the symptoms worsened. She underwent two more scans (1 MRI and 1 PET) that indicated an enhancing polypoidal mass in the knee joint, and two arthroscopic procedures. The histopathology report indicated an ALK-positive ALCL. She was treated with Brentuximab vedotin + CHP followed by involved-site radiotherapy to the postoperative region with margins. The patient has had a complete clinical and pathological response which was assessed after 1 year from the start of the treatment. Conclusion: This is the first instance of primary ALK-positive ALCL affecting the knee joint that has been documented, to the best of our knowledge. The case emphasizes the significance of taking ALCL into account when determining the differential diagnosis of knee joint tumors as well as the requirement for a thorough assessment of extranodal involvement. Keywords: Lymphoma, knee joint, ALCL, extranodal lymphoma, ISRT, chemotherapy, arthroscopic surgery.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Anaplastic Large Cell Lymphoma of the Knee Joint

Zade,

Rao,

Patil

et al. 2023

JOCR

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“…Primary lymphoma of bone mimicking a monoarticular synovial process has been reported infrequently. Lee et al 12 and Rice et al 13 each described a case that presented as knee monoarthritis, and Harzy et al 14 described a case that appeared as elbow monoarthritis. However, each of these cases had conventional radiographic findings of a bone lesion, unlike the radiographic findings in our case.…”

Section: Discussionmentioning

confidence: 99%

Primary Lymphoma of the Distal Femur Presenting as Spontaneous Deep Vein Thrombosis and Knee Monoarthritis

Jalloh

Ahlawat

Gross

et al. 2021

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Case: A 68-year-old man with a history of unprovoked deep vein thrombosis (DVT) presented with recurrent knee effusions after the initiation of anticoagulation. Radiographs showed soft-tissue swelling without a distinct skeletal lesion. Magnetic resonance imaging, however, showed a marrow-replacing process in the distal femur. Subsequent biopsy demonstrated B-cell lymphoma. Conclusion: This is a rare case of a primary lymphoma of bone mimicking synovial disease. It also highlights the fact that an unprovoked DVT may be a harbinger of an undiagnosed underlying malignancy.

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“…Less common synovial tumours are synovial haemangioma, diffuse articular lipomatosis (lipoma arborescens), synovial chondroma or fibroma (intracapsular and periarticular), synovial chondrosarcoma, synovial sarcoma, or lymphoma. 18,19 Practically, any micro-organism can lead to joint infection. The main causative micro-organisms of joint infection in native joints are Staphylococcus aureus (which causes most acute bacterial joint infection in adults and children more than 2 years old including 80% of infections in patients with rheumatoid arthritis), Neisseria gonorrhoeae (which is a common source of joint infection in sexually active young adults), Streptococcal series, such as Streptoccocus viridans, Streptoccocus pneumonia and Group B Streptococci, as well as aerobic Gram-negative rods.…”

Section: Indications For Synovial Biopsymentioning

confidence: 99%