Non-Hodgkin?s lymphoma in southeast Turkey: clinicopathologic features of 490 cases

Abstract

We have carried out a retrospective analysis of 490 non-Hodgkin's lymphomas (NHLs), followed at our clinic, with the purpose of evaluating the clinicopathologic features of these patients. The patients were assessed with regard to their characteristics including age, gender, histologic distribution, stage, extranodal involvement, presenting symptoms, and biopsied site. Of the patients 314 (64%) were male and 176 (36%) were female. The overall median age was 43 years (range: 14-90). The patients were classified according to the Working Formulation (WF) system: 71 (14.4%) were low grade, 342 (69.8%) were intermediate grade, 43 (8.7%) were high grade, and 34 (6.7%) had other lymphomas. Intermediate-grade non-Hodgkin's lymphomas formed the largest group, of whom 320 patients' paraffin blocks were available for Revised European and American lymphoma (REAL) classification: 78% were B-cell lymphomas, whereas 16% were T/NK lymphomas. Six percent of cases were unclassified lymphomas. Diffuse large B-cell lymphoma (DLBCL) was the most commonly observed histopathologic type in 132 (41%) patients. Extranodal involvement was found in 218 (44.5%) patients. The most commonly affected extranodal sites were small bowel, stomach, and tonsil in 72 (33%), 63 (29%), and 19 (8.7%) patients, respectively. According to the Ann Arbor staging system, the vast majority of patients (89.4%) were advanced stage. In conclusion,The characteristics of NHLs in our region show some differences from the other sites of Turkey and the world.

Clinical and pathological evaluation of histopathological subtypes in patients with non-Hodgkin’s lymphoma

“…Similarly, in the literature the most frequently reported histological subtype was also DLBCL. Some data have indicated follicular subtype as the most frequently seen histological subtype [2,18,19]. In our study 9.7% of our patients had follicular lymphomas.…”

“…Clinical features of NHL demonstrate changes with geographical factors. Determination of the characteristics of the patients living in different regions, and definition of different prognostic parameters are very important [2,3]. Since NHL represents a very heterogeneous disease group, determination of prognostic factors, and identification of patient groups with poor prognosis have a crucial importance [4].…”

Gastrointestinal lymphoma in Western Algeria: pattern of distribution and histological subtypes (retrospective study)

“…Gastrointestinal lymphoma in Western Algeria: pattern of distribution and histological subtypes (retrospective study) the world (8). Also, it seems that the epidemiologic pattern in GI tract lymphoma is changing (9).…”

Peripheral T cell lymphoma in Asia

“…The incidence and distribution of T-and NK-cell lymphomas in several Asian countries is summarized in Fig. 1 and Table 1 [ [4][5][6][7][8][9][10][11][12][13][14][15].The frequencies of T-and NK-cell lymphomas seem to increase from West to East Asia. The occurrence rate of Tand NK-cell lymphomas are relatively low (\20 % of NHL) mainly in West Asia (Turkey 16.2 %, Iraq 19 %, and Kuwait 18 %) and South Asia (Pakistan 11.3 %, and India 20.2 %), but relatively high mainly in East Asia (China 32.5 %, Korea 22 %, and Japan 24.9 %) and Southeast Asia (Thailand 25 %).…”

“…The incidence and distribution of T-and NK-cell lymphomas in several Asian countries is summarized in Fig. 1 and Table 1 [ [4][5][6][7][8][9][10][11][12][13][14][15].…”