Non-hodgkin's lymphoma: Case control epidemiological study in Yorkshire

Cartwright, R. A.; McKinney, Patricia A.; O’Brien, Claire; Richards, I. D. G.; Roberts, B. E.; Lauder, I.; Darwin, Cdc; Bernard, Shulamit; Bird, C. C.

doi:10.1016/s0145-2126(98)80012-x

Cited by 164 publications

(134 citation statements)

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“…The present data are consistent with the general evidence on the issue, since of two cohort studies one found a direct (Kato et al, 1992) and one an inverse association (Chiu et al, 1999), and of four case -control studies one found a direct (De Stefani et al, 1998), one an inverse (Nelson et al, 1997) and two no appreciable association (Cartwright et al, 1988;Brown et al, 1992). Thus, they provide convincing evidence that alcohol drinkingmainly wine, even in relatively high amounts -is not appreciably related to the risk of lymphoid neoplasms.…”

Section: Discussionsupporting

confidence: 91%

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Alcohol drinking and risk of non-Hodgkin's lymphoma

et al. 2001

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Objective: To analyse the relation between alcohol intake and the risk of non-Hodgkin's lymphoma (NHL). Design: Hospital-based case -control study. Settings: The greater Milan area and the province of Pordenone, Northern Italy. Subjects: Cases were 446 (256 men and 190 women) with histologically confirmed incident NHL, and controls were 1295 (791 men and 504 women) with acute non-neoplastic conditions. Results: Compared to non-drinkers, the odds ratio (OR) was 0.92 for < 3 drinks per day, 0.98 for 3 -6 drinks, and 1.02 for 7 drinks per day. Wine drinking was also not associated with risk, and the OR was 0.85 for drinkers of 7 drinks=day compared to non-drinkers. Beer and spirit intake was also not associated with NHL risk. Conclusions: Our study, based on a population with relatively high alcohol intakes, indicates that there is no appreciable association between intake of various alcoholic beverages and the risk of NHL. Sponsorship:

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Section: Discussionsupporting

confidence: 91%

“…Case -control studies showed inconsistent results too, since one found a direct association (De Stefani et al, 1998), and others reported no (Cartwright et al, 1988;Brown et al, 1992) or inverse associations (Nelson et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Alcohol drinking and risk of non-Hodgkin's lymphoma

et al. 2001

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“…48 They were also consistent with results from 5 populationbased case-control studies carried out in USA, 19,21,36 Canada 31 and France 17 and with 3 hospital-based case-control studies conducted in France, 13 Sweden 20 and United Kingdom. 15 In addition, an American cohort study following women for 14 years did not report any association between tobacco smoking and the development of NHL overall. 12 Nevertheless, our analyses for specific histological subtypes failed to confirm the association between smoking and follicular NHL recently reported by Interlymph 48 and also found in 3 cohort studies carried out in USA 7,10 and in Sweden.…”

Section: Discussionmentioning

confidence: 95%

Tobacco smoking, alcohol drinking and non‐Hodgkin's lymphoma: A European multicenter case‐control study (Epilymph)

Besson

Brennan

Becker

et al. 2006

Intl Journal of Cancer

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To study the role of tobacco smoking and alcohol drinking in the etiology of non-Hodgkin's lymphoma (NHL), we conducted a multicenter case-control study in Spain, France, Germany, Italy, Ireland and Czech Republic between 1998 and 2004, which included 1,742 cases of NHL and 2,465 controls matched on age, sex and recruitment area. Tobacco smoking was not associated with the risk of NHL overall or with risk of specific histological subtypes. Similarly, there was no association between alcohol drinking and the risk of NHL overall or across histological subtypes. However, a protective effect of alcohol drinking was observed among men (OR 5 0.76, 95% CI 5 0.62-0.93) and in non-Mediterranean countries (OR 5 0.73, 95% CI 5 0.61-0.86). There was no evidence of interaction between alcohol drinking and tobacco smoking in NHL etiology. The results of this large-scale European study did not support an association between tobacco and NHL and suggested a protective effect of alcohol on development of NHL for men and in non-Mediterranean countries. ' 2006 Wiley-Liss, Inc.Key words: lymphoma; non-Hodgkin's; tobacco; alcohol; EuropeThe incidence of non-Hodgkin's lymphoma (NHL) has increased considerably in the last few decades in all countries with reliable information. 1 In Europe, between the early and the late 1990s, the rise in mortality was 5% for men and 8% for women. 2 There is no clear explanation of this phenomenon. To date, the established risk factors for NHL are autoimmune diseases, 3 infection with human immunodeficiency virus and human T-cell leukemia/lymphoma virus, 4 but these factors explain only a small proportion of the etiology of NHL. The role of tobacco smoking and alcohol drinking in the development of NHL remains uncertain partly due to the small sample sizes of previous epidemiologic studies. Recently, the International Lymphoma Epidemiology Consortium (Interlymph) has reported results based on pooled data of studies from Europe, 32-34 USA 22,28,39,45 and Australia. 46 In this analysis based on 6,492 cases of NHL and 8,683 controls, a slight inverse association was found between alcohol intake and the development of NHL. 47 The analysis of the effect of tobacco smoking, based on 6,594 cases of NHL and 8,892 controls, reported a slightly increased risk of NHL overall and of B-cell follicular lymphoma in particular. 48 Thus, we have attempted to confirm the results of the pooled analysis using data from an independent European multicenter case-control study (Epilymph). Material and methodsOur investigation was conducted in 7 European countries (Czech Republic, Finland, France, Germany, Ireland, Italy, and Spain), but data from Finland were not included in this analysis because of methodological issues, in particular, controls were not matched to cases on age, sex and residence area, as done in other study centers, and the present study is based on data from 6 countries.Histologically or cytologically confirmed incident cases of lymphoma were recruited from 1998 to 2004 (Table I). Cases were classified ac...

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“…18 In addition, 3 case-control studies conducted in the US and UK found significantly elevated odds ratios ranging from approximately 1.5 to 3 for persons who reported being Jewish or raised in a Jewish household as compared to other persons. [20][21][22] Groves et al, 23 using data from the National Cancer Institute's (NCI) Surveillance Epidemiology and End Results (SEER) program, evaluated NHL incidence according to 5 histologic types: small lymphocytic, follicular, diffuse, high-grade, peripheral Tcell, and not otherwise specified (NOS). They observed several differences in the distribution of NHL type according to sex, race, time trends, and age, including higher rates of follicular NHL among whites than among blacks, higher rates of peripheral T-cell NHL among blacks than among whites and among males than among females, and evidence that rates of follicular NHL were increasing more rapidly in black males than in other groups.…”

Section: Descriptive Epidemiologymentioning

confidence: 99%

“…191,195 Numerous studies examined the relation between solvent exposure and risk of NHL. When solvents were evaluated as a general category, most studies observed nonsignificant positive associations with NHL risk, 20,21,29,71,105,118,129,170,202 and 2 reported inverse associations. 114,142 No association between occupational exposure to organic solvents and lymphatic and hematopoietic cancer was reported in a meta-analysis of 26 studies (meta-SMR 5 1.05, 95% CI: 0.92-1.21).…”

Section: Occupational and Environmental Chemical Exposurementioning

confidence: 99%