Non‐Hodgkin's lymphoma arising in adenolymphoma—a report of two cases

Banik, Sujoy; Wright, D. H.

doi:10.1002/path.1711460303

Cited by 40 publications

(25 citation statements)

References 33 publications

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“…20,21 The possibility for the lymphoma to originate in the lymphoid tissue of WT is supported by several reports indicating that WT-associated lymphoma may remain a localized disease for long periods of time. [5][6][7][14][15][16]19 Concerning the site of origin of HL evidences are inconclusive; in our case and in 2 of the 3 reported cases, the disease was simultaneously present in WT and in cervical lymph nodes 9,21 whereas, in the remaining case it exclusively involved an intraparotid lymph node. 13 In conclusion, the present study shows that the lymphoid stroma of WT may be the site of NLPHL and hence, it has to be carefully investigated, considering that the histological diagnosis of NLPHL may be very insidious especially in the context of another disease such as WT.…”

Section: Discussioncontrasting

confidence: 70%

Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland

et al. 2015

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Hodgkin lymphoma (HL) associated with Warthin tumor (WT) is extremely rare, accounting for only 3 cases of classical HLs. Here, we report for the first time the occurrence of a nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) involving the lymphoid stroma of a WT of the parotid gland. Pathogenesis of WT is controversial, with both a nodal and a parenchymal possible origin. On the other hand, extranodal involvement by HLs is uncommon. In our case, the coexistence of a WT and of a NLPHL within its stroma and in cervical lymph node emphasizes the importance of a careful evaluation of the lymphoid tissue in WT in order to exclude the possibility of an associated lymphoid malignancy.

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Section: Discussioncontrasting

confidence: 70%

Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland

et al. 2015

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“…Lymphomas associated with WT are extremely rare. A review of the English literature provided 23 cases of WT related to malignant lymphoma (Table 1) [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Considering only the cases with existing data, this association occurred in eighteen males (81,8%) and four females (18,2%), with a mean age of 67 years.…”

Section: Discussionmentioning

confidence: 99%

“…Uncommonly, the lymphoid stroma in WT is infiltrated by malignant lymphoma. To date, there are 23 reported cases in the English literature of lymphomas associated with WT [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Most cases are B cell lymphomas-namely follicular lymphoma [2, 4-8, 11, 12, 14, 15], small lymphocytic lymphoma [10,18] and diffuse large B-cell lymphoma [8,19]-and are usually associated with generalized disease, which is either present at the time of diagnosis or develops subsequently.…”

Section: Introductionmentioning

confidence: 99%

T cell lymphoblastic lymphoma in parotidectomy for Warthin’s tumor: case report and review of the literature

et al. 2009

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Lymphomas associated with Warthin's tumor (WT) are extremely uncommon and the majorities are of B cell type. We report the simultaneous occurrence of T-cell lymphoblastic lymphoma (T-LBL) and WT in an 81-year-old patient, who presented with fever, night sweats and enlargement of the right parotid gland. The parotidectomy specimen showed a WT with extensive replacement of the lymphoid stroma by T-LBL, but preservation of the oncocytic epithelium. Staging investigations revealed mediastinal and abdominal lymphadenopathy, bilateral pleural effusions and bone marrow infiltration, in keeping with stage IVB disease. The patient received combination chemotherapy treatment but responded poorly, and died three months after diagnosis. To our knowledge, this is the first case report of T-LBL involving WT. The present study indicates that the lymphoid stroma in WT belongs to the systemic lymphoid tissue and can be involved in disseminated lymphoma. It highlights the importance of careful examination of WT's lymphoid stroma for the possible presence of any coexistent malignancy.

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“…2 In very rare instances, malignancy can arise in conjunction with a Warthin's tumor, either in the form of lymphoma or carcinoma. [12][13][14] It remains controversial whether these are merely synchronous lesions, or are related pathogenetically. The extremely low rate of malignancy, as compared to that seen in pleomorphic adenoma (carcinoma ex pleomorphic adenoma) suggests that the tumors are synchronous rather than clonally related.…”

Section: Discussionmentioning

confidence: 99%

Molecular assessment of allelic loss in Warthin tumors

2005

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Warthin's tumors are benign lesions of the head and neck that have a characteristic morphologic appearance. The etiology of Warthin's tumors is controversial and whether they are true neoplasms or developmental malformations continues to be debated. In this study, we examined 12 Warthin tumors with a molecular and immunohistochemical approach. Immunostains for p53 and p16ink were performed. The epithelial and lymphoid components of each lesion were microdissected and PCR was performed for 13 microsatellite markers at or near common tumor suppressor genes. The results were analyzed semiquantitatively using capillary electrophoresis. Frequency of allelic loss was calculated. The epithelial component of all tumors was negative for p53 and p16ink. By molecular genotyping there was only one case that had one locus with allelic imbalance, while the remainder had no evidence of clonal allelic loss. The immunohistochemical and molecular results in this study lend support to the hypothesis that Warthin tumors are non-neoplastic, as there was no evidence of aberrant staining for tumor suppressor gene protein products and no evidence of consistent clonal allelic losses. Modern Pathology (2005) 18, 964-968.

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Non‐Hodgkin's lymphoma arising in adenolymphoma—a report of two cases

Abstract: Two cases of follicle centre cell lymphoma, apparently arising within adenolymphomas of the parotid gland, are reported. These are discussed in relation to the histogenesis of adenolymphoma and their possible relationship to mucosa-associated lymphoid tissue.

Cited by 40 publications

References 33 publications

Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland

Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland

T cell lymphoblastic lymphoma in parotidectomy for Warthin’s tumor: case report and review of the literature

Molecular assessment of allelic loss in Warthin tumors

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