Non‐Hodgkin's lymphoma and other cancers among a cohort of patients with systemic lupus erythematosus

Mellemkjér, Lene; Andersen, Vagn; Linet, Martha S.; Gridley, Gloria; Hoover, Robert N.; Olsen, Jørgen H.

doi:10.1002/art.1780400424

Cited by 226 publications

(211 citation statements)

References 34 publications

(26 reference statements)

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“…Other shortcomings include the use of NHL classifications preceding the recently introduced WHO classification (41) and the lack of information on treatments of autoimmune diseases, such as immunosuppressive therapy. Previous Scandinavian studies based on hospital and cancer registries have evaluated cancer risk among persons with single autoimmune conditions but were generally limited by the small number of NHL outcomes (42)(43)(44)(45)(46)(47)(48)(49)(50). Family history of RA and risk of NHL was assessed in a registry-based study from Sweden (42).…”

Section: Discussionmentioning

confidence: 99%

Autoimmune disease in individuals and close family members and susceptibility to non‐Hodgkin's lymphoma

Mellemkjær¹,

Pfeiffer²,

Engels³

et al. 2008

Arthritis & Rheumatism

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109

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Objective. Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjögren's syndrome have been consistently associated with an increased risk of non-Hodgkin's lymphoma (NHL). This study was initiated to evaluate the risks of NHL associated with a personal or family history of a wide range of autoimmune diseases.Methods ). An increased risk of NHL was found for a personal history of 5 nonsystemic autoimmune conditions (autoimmune hemolytic anemia, Hashimoto thyroiditis, Crohn's disease, psoriasis, and sarcoidosis) (OR h ranged from 1.5 to 2.6) of 27 conditions examined.Conclusion. Overall, our results demonstrate a strong relationship of personal history of systemic autoimmune diseases with NHL risk and suggest that shared susceptibility may explain a very small fraction of this increase, at best. Positive associations were found for a personal history of some, though far from all, nonsystemic autoimmune conditions.

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Section: Discussionmentioning

confidence: 99%

Autoimmune disease in individuals and close family members and susceptibility to non‐Hodgkin's lymphoma

Mellemkjær¹,

Pfeiffer²,

Engels³

et al. 2008

Arthritis & Rheumatism

Self Cite

109

106

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“…However, immunosuppressive therapy may negatively impact a patient's condition when he or she has an underlying infection. In addition, extra caution must be taken in the case of coexistence of malignancies as an increased risk of malignancies has been reported in SLE patients (1). Here we report a female SLE patient with multiple nodular lesions in the lungs and bones, which first made us suspect a malignancy or infection.…”

Section: Introductionmentioning

confidence: 78%

A case of systemic lupus erythematosus with multiple nodules in the bilateral lungs and vertebrae

2016

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We encountered a case of a middle-aged woman with systemic lupus erythematosus. As the patient had progressive peripheral neuropathy including foot drop, we intended to treat her with intensive immunosuppressive therapy as soon as possible. Pretreatment assessment, however, revealed multiple nodular lesions in the lungs and bones, suggesting disseminated tumor metastasis or miliary tuberculosis. To our surprise, gallium and bone scintigraphy as well as cytodiagnosis revealed no sign of malignancy or infection, leading us to suspect the presence of another multisystem disorder. The presence of subependymal nodules and a periungual fibroma strongly suggested tuberous sclerosis (TS). A genetic test revealed a mutation in the TSC1 gene and confirmed the diagnosis. Thus, the multiple nodular lesions were most likely a hyperplasia due to TS. Although the odds of a comorbidity of more than one multisystem disorder are considered to be quite low, it should be kept in mind that when such a situation does exist, the comorbidity may make the presenting symptoms extremely diverse.

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“…A multicentre international cohort study was performed by Bin J et al [24] to provide a brief report of the lung cancer cases from an SLE cohort and concluded that histological pattern of distribution of lung cancer were similar in SLE cohort and in general population but incidence of malignancy was slightly high in SLE cohorts when compared with general population with a standardized incidence rate 1.37, but hasn't thrown light on the exact mechanism of coexistence [24]. Incidence of SLE and lung cancer was higher in women [25][26][27][28]. The reported incidence of lung cancers coexisting with SLE or vice verse in Indian population compared to western population are very few, the incidence is being less than 2% [1].…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma of Lung Associated with Rare Cutaneousparaneoplastic Syndrome-Systemic Lupus Erythromatosus (SLE)

R¹,

Sreenath²,

Patil³

et al. 2017

MOJCR

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The burden of lung cancer isrising at alarming rates. Their coexistence with cutaneousparaneoplastic syndromes is not uncommon. We observed nests of malignant cells from the lung biopsy, hyperkeratosis with lymphocytic infiltration at the dermoepidermal junction from the biopsies of the skin lesion in an elderly man with history of addiction to nicotine and tobacco smoke. An immunological assay targeting auto-antibodiesdsDNA and ANA were identified, possibly establishing an unknown and uncommon mechanism common to both lung cancer and Systemic Lupus Erythematosus (SLE).throughout the globe with significant differences in the patterns and presentations from region to region [3].Various etiological factors have been identified, but the most striking causative factors are cigarette smoke, tobacco smoke and exposure to inhaled carcinogens. The ratios of smokers versus non smokers have been compared and are at a raise. There are variations in the demographic patterns of distributions in the histology's of lung cancers. In many Western countries adenocarcinoma has become the commonest [4,5] while most of the Indian studies have described squamous cell carcinoma as the commonest histology in both men and women [6,7] however change in the pattern has emerged [8,9].

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Non‐Hodgkin's lymphoma and other cancers among a cohort of patients with systemic lupus erythematosus

Cited by 226 publications

References 34 publications

Autoimmune disease in individuals and close family members and susceptibility to non‐Hodgkin's lymphoma

Autoimmune disease in individuals and close family members and susceptibility to non‐Hodgkin's lymphoma

A case of systemic lupus erythematosus with multiple nodules in the bilateral lungs and vertebrae

Squamous Cell Carcinoma of Lung Associated with Rare Cutaneousparaneoplastic Syndrome-Systemic Lupus Erythromatosus (SLE)

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