Non-Hodgkin's lymphoma and exposure to phenoxyherbicides, chlorophenols, fencing work, and meat works employment: a case-control study.

Pearce, Neil; Smith, Allan H.; Howard, J. Keir; Sheppard, Raewyn A.; Giles, H J; Teague, Clinton A.

doi:10.1136/oem.43.2.75

Cited by 61 publications

(49 citation statements)

References 18 publications

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“…The risk increase ratios vary between 0.9 and 4.7 (Hardell et al, 1981;Pearce et al, 1986, Woods et al, 1987Olsson et al, 1988;Kogevinas et al, 1995;Pahwa et al, 2012). The relationship between the use of pesticides and development of NHL has also been investigated in two cohort studies, which identified a borderline increase in risk (Kogevinas et al, 1997;Bertazzi et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin Lymphoma and Pesticide Exposure in Turkey

Yıldırım¹,

Karakilinc²,

Yıldız³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Non-Hodgkin lymphoma (NHL) is a solid tumour of lymphocytes, important elements in the immune system. According to 2006 data, in Turkey the incidence was 6.5 per 100,000 in males, and 4.4 in females. The relationship between the use of pesticides and development of NHL has been extensively investigated in many studies, and it has been demonstrated that the risk of NHL is increased by exposure to such compounds. Antalya is a region of intensive agricultural activity. In this study, the relationship between the incidence of lymphoma in Antalya and the amount of pesticides employed was investigated. Materials and Methods: The study used data from 1995 to 2010 on the patients from the databank of TR Ministry of Health, Antalya Provincial Health Directorate, Cancer Registration Center and the patients who were histopathologically diagnosed with NHL during these years. Results: The relationship between the amount of pesticide used and the incidence was studied with the Spearman correlation analysis and the p value was found as 0.05. The correlation coefficient was 0.497. An increase in the NHL incidence over the years was identified, with a 2.42-fold increment found from 1995 to 2005 and a 2.77 fold elevation from 1995 to 2010. The use of pesticides increased 1.89 fold over the same period. Conclusions: Our study investigated the relationship of the pesticides used with NHL patients diagnosed during the same year. Since the time elapsing after exposure to pesticides until the development of cancer is not clear, no comparison can be made at present. We believe that the increase in use of pesticides since 1995 may be associated with the increase in the incidence of NHLand therefore that further studies on the issue including measurements of serum pesticide levels, are required.,

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Section: Discussionmentioning

confidence: 99%

Non-Hodgkin Lymphoma and Pesticide Exposure in Turkey

Yıldırım¹,

Karakilinc²,

Yıldız³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…They involve agricultural occupations [7][8][9][10][11][12] and contact with cattle. [13][14][15][16][17][18] Several authors also report an elevated risk for these neoplasms in butchers, abattoir workers and meat cutters. 16,19,20 Additional incriminated factors were occupational exposure to pesticides, industrial paints and solvents, forestry work, the leather industry and hair dyes.…”

Section: Epidemiologic Datamentioning

confidence: 99%

Virus target cell conditioning model to explain some epidemiologic characteristics of childhood leukemias and lymphomas

Hausen

Villiers

2005

Intl Journal of Cancer

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Frequent infections in early childhood, whole-day care and a socially unprivileged environment have been reported as protective factors for childhood leukemias and lymphomas. Conversely, a protected social environment, higher level of education and growing up in families with a low number of children are considered as risk factors. Additional risk factors involve agricultural occupation of the parents and exposure to several other occupational factors. These data led to a number of hypotheses that attempted to explain the epidemiologic observations; however, a number of questions are still open. Here we propose a new concept that could explain most of the epidemiologic characteristics. This concept is based on the assumption that persistent infections with TT virus-like agents increase the risk for specific chromosomal translocations. This risk should correlate with the viral load.Interferon induction by intermittent infections should reduce the viral load and thus decrease the risk for chromosomal modifications. Some virologic observations in support of this model are presented. ' 2005 Wiley-Liss, Inc.

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“…Many epidemiologic studies have been conducted and are currently underway to evaluate the chronic effects of these pesticides in occupational groups, such as manufacturers, professional turf applicators, farmers, forestry and railroad workers, Vietnam veterans and others ( Axelson et al, 1980;Ott et al, 1980;Riihimaki et al, 1982;Coggon et al, 1986;Coggon et al, 1991;Hoar et al, 1986;Pearce et al, 1986;Hoar Zahm, 1987;Lynge, 1987;Lynge, 1993;Vineis et al, 1987;Bond et al, 1988;Eriksson et al, 1990;Wigle et al, 1990;Green, 1991;Lerda and Rizzi, 1991;Saracci et al, 1991;Swaen et al, 1992;Bloemen et al, 1993;Bueno de Mesquita et al, 1993;Kogevinas et al, 1993;Kogevinas et al, 1997;Alavanja et al, 1996;Zahm, 1997;Zahm et al, 1990). Although the current weight of epidemiological evidence suggests an association between the use of 2,4 -D and some cancers, a cause -effect relationship has not been established.…”

Section: Introductionmentioning

confidence: 99%

Development of models to predict dose of pesticides in professional turf applicators

Harris

Sass-Kortsāk

Corey

et al. 2002

J Expo Sci Environ Epidemiol

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Epidemiologic studies designed to assess the chronic effects of pesticides are limited by inadequate measurements of exposures. Although cohort studies have been initiated to evaluate the effects of 2,4 -dichlorophenoxyacetic acid ( 2,4 -D ) and other pesticides in professional turf applicators, they may have limited power to detect significant health risks and may be subject to bias from exposure measurement error. In this study, the doses of 2,4 -D, mecoprop [ 2 -( 4 -chloro -2 methylphenoxy ) propionic acid, MCPP ] and dicamba ( 3,6 -dichloro -o -anisic acid ) were evaluated in a group of 98 professional turf applicators from 20 companies across southwestern Ontario. During a 1 -week period ( Saturday to Thursday ), the volume of pesticide ( active ingredient ) applied was only weakly related to the total dose of 2,4 -D absorbed ( R 2 = 0.21 ). Two additional factors explained a large proportion of variation in dose: the type of spray nozzle used and the use of gloves while spraying. Individuals who used a fan -type nozzle had significantly higher doses than those who used a gun -type nozzle. Glove use was associated with significantly lower doses. Job satisfaction and current smoking influenced the dose but were not highly predictive. In the final multiple regression models predicting total absorbed dose of 2,4 -D and mecoprop, approximately 63 -68% of the variation was explained. The future application of these models for epidemiologic research will depend on the availability of information and records from employers, the feasibility of contacting study subjects and cost.

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Non-Hodgkin's lymphoma and exposure to phenoxyherbicides, chlorophenols, fencing work, and meat works employment: a case-control study.

Cited by 61 publications

References 18 publications

Non-Hodgkin Lymphoma and Pesticide Exposure in Turkey

Non-Hodgkin Lymphoma and Pesticide Exposure in Turkey

Virus target cell conditioning model to explain some epidemiologic characteristics of childhood leukemias and lymphomas

Development of models to predict dose of pesticides in professional turf applicators

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