Non‐Hodgkin's Lymphoma

Abstract

Overview The malignant lymphomas are neoplastic transformations of cells that reside predominantly within lymphoid tissues. Although Hodgkin and non‐Hodgkin lymphomas (NHLs) both infiltrate lymphohematopoietic tissues, their biologic and clinical behaviors are distinct. They differ with neoplastic cells of origin, sites of disease, presence of specific symptoms, and response to treatment. Although both are among the most sensitive malignancies to radiation and cytotoxic therapy, their cure rates markedly differ. Hodgkin lymphomas are cured in nearly 80% of all patients employing both conventional and salvage treatment strategies whereas NHLs are cured in fewer than 50% of patients.