Non-Hodgkin Lymphomas Presenting with Spinal Epidural Involvement

Marco, A. Dr; Campostrini, Franco; Garusi, G. F.

doi:10.3109/02841868909092255

Cited by 24 publications

(10 citation statements)

References 19 publications

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“…Lymphoma is a systemic disease in which spinal involvement by lymphoma is not uncommon (2,4,5,13). It commonly involves paravertebral lymph nodes and then invades adjacent vertebrae and extends through the intervertebral foramina to the epidural space (6,14,15).…”

Section: Discussionmentioning

confidence: 99%

MR Imaging of Spinal Lymphoma

Li¹,

Holtås²,

Larsson³

1992

Acta Radiol

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Fourteen patients with spinal lymphoma examined by MR imaging were reviewed. Thirteen of them also had extraspinal lymphoma. Vertebral involvement was found in 12 patients, epidural in 10, and paraspinal in 8 patients. On the basis of MR imaging at 0.3 T, spinal lymphoma may be divided into three types of growth pattern according to the main location: paraspinal, vertebral, and epidural. Most frequently, all three locations were found simultaneously on MR (7/14). In one patient the location was vertebral with epidural extension, in one paraspinal with vertebral extension, in 3 it was entirely vertebral, and in 2 entirely epidural. Multiple plane TI-weighted imaging gave complete information about the extent of spinal lymphoma. The signal intensity was lower than or equal to muscle and lower than bone marrow in paraspinal and vertebral lesions on TI-weighted images and high on TZweighted images. Epidural lesions showed a hypo-or isointense signal relative to the cord on TI-weighted images except in one case and a hyperintense signal on T2-weighted images. Compression of the cord and cauda equina due to bulging of diseased vertebral bodies and epidural lesions was well demonstrated. MR imaging was also found useful in the follow-up of treatment.

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Section: Discussionmentioning

confidence: 99%

MR Imaging of Spinal Lymphoma

Li¹,

Holtås²,

Larsson³

1992

Acta Radiol

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“…This was supported by pre-rituximab studies with risk estimates of 8 % [25,[29][30][31][32][33][34][35][36]. Unfortunately, interpretation of these studies is made difficult by the inclusion of patients with Burkitt lymphoma.…”

Section: Epiduralmentioning

confidence: 98%

Central Nervous System Prophylaxis in Non-Hodgkin Lymphoma: Who, What, and When?

Cheah

Seymour

2015

Curr Oncol Rep

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Secondary central nervous system (CNS) progression in patients with non-Hodgkin lymphoma (NHL) is associated with a particularly poor prognosis. In this review, we summarize and critically evaluate the current literature to guide the practicing clinician in estimating CNS relapse risk in order to select individual patients who may benefit from CNS prophylaxis, covering histologic subtype, anatomic location, and molecular and clinical factors. We summarize the data regarding different prophylaxis strategies used and provide our recommendation regarding who should receive it, what they should receive, and when it should be administered.

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“…For the same reason, meningiomas commonly localize to the same cranial sites and thus represent the major preoperative consideration in all the patients with primary dura mater lymphomas. This is in marked contrast to the spinal epidural space in which aggressive lymphomas, especially of the diffuse large cell type, are more common, wheras MALT lymphomas are not reported [40,41]. The origin of primary cranial dural and spinal epidural lymphomas is also different.…”

Section: Discussionmentioning

confidence: 73%

Primary lymphoblastic B-cell lymphoma of the cranial dura mater: a case report and review of the literature

Abdullah¹,

Morgensztern²,

Rosado³

2005

Leukemia & Lymphoma

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Primary lymphomas of the cranial dura mater are rare. Mucosa-associated lymphoid tissue extranodal marginal zone lymphomas are the most common subtype of non-Hodgkin's lymphomas that present as primary cranial dura tumors. A 33 year-old male presented with a 3-month history of a growing lump in the right frontal area. Neuroimaging studies demonstrated an extra-axial, broad-based mass with a dural tail in the right frontal bone convexity. Biopsy led to the diagnosis of localized dural precursor B-cell lymphoblastic lymphoma. The patient was treated with a combination of chemotherapy and radiotherapy, achieving durable disease-free survival. This is the first report of precursor B-cell lymphoblastic lymphoma of dura mater. A review of the literature on primary lymphomas of cranial dura mater is presented. Primary lymphomas of the cranial dura mater are rare. Mucosa-associated lymphoid tissue extranodal marginal zone lymphomas are the most common subtype of non-Hodgkin's lymphomas that present as primary cranial dura tumors. A 33 year-old male presented with a 3-month history of a growing lump in the right frontal area. Neuroimaging studies demonstrated an extra-axial, broad-based mass with a dural tail in the right frontal bone convexity. Biopsy led to the diagnosis of localized dural precursor B-cell lymphoblastic lymphoma. The patient was treated with a combination of chemotherapy and radiotherapy, achieving durable disease-free survival. This is the first report of precursor B-cell lymphoblastic lymphoma of dura mater. A review of the literature on primary lymphomas of cranial dura mater is presented.

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Non-Hodgkin Lymphomas Presenting with Spinal Epidural Involvement

Cited by 24 publications

References 19 publications

MR Imaging of Spinal Lymphoma

MR Imaging of Spinal Lymphoma

Central Nervous System Prophylaxis in Non-Hodgkin Lymphoma: Who, What, and When?

Primary lymphoblastic B-cell lymphoma of the cranial dura mater: a case report and review of the literature

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