Non-Hodgkin Lymphoma Presenting With Uveitis Occurring After Blunt Trauma

Abstract

We report here an unusual patient suffering from visual loss with refractory uveitis which was occured after a blunt trauma to her left eye. While in the hospital cervical lymph node and anterior chamber aspiration cytology with immunohistochemical staining were performed. The histopathologic diagnosis was highly malignant B-cell non-Hodgkin lymphoma. After the inflammation of the eye was regressed with chemotherapy, pars plana vitrectomy-lensectomy was performed. She was free of inflammation and the best corrected visual acuity was increased. However, she had a refractory inflammatory episode with clumps of cells in the anterior chamber 10 months after the operation. Local radiotherapy to the left eye was applied. Radiotherapy provided local control and preservation of the vision. The present case is presented in order to emphasize the importance of systemic evaluation in uveitis and possible role of trauma leading migration of atypical cells into the eye.

Diffuse large B‐cell lymphoma presenting as large anterior chest wall mass involving pleura and lung: A possible result of post‐traumatic chronic inflammation

“…Non‐Hodgkin's lymphoma can have multiple etiologies, including immunodeficiency, viral infections (such the Epstein Barr virus), radioactive contaminations, and hybrid genes resulting from translocation 3 . There have been several reports in which lymphoma developed after blunt trauma, the majority were described in the head and neck; 3–5 in the chest wall, the literature presents cases of lymphoma in patients with a long history of chronic tuberculous pyothorax or a history of artificial pneumothorax, and most cases are reported in Japan 6 . These lymphoma have been designated pyothorax‐associated lymphoma and show features of DLBCL similar to those developed from other chronic inflammatory conditions, 7 such as the use of metallic implants in bones and joints, 8 chronic osteomyelitis, 9 chronic venous ulcer 9 and the use of surgical mesh implant 10 .…”

Nonleukemic granulocytic sarcoma of orbit after blunt trauma

“…During our research, reported cases related to lymphoma usually, initiate at head after blunt trauma, such as scalp, [ 1 ] oculus, [ 2 ] and uveitis. [ 4 ] Blunt trauma can cause local tissue degeneration, and necrosis, and finally, result in cell atypia during the healing process. [ 2 ] Almost all of the reported cases were non- Hodgkin's lymphoma, but there was not any case of post-trauma nonleukemic GS.…”

“…[ 14 ] But for hematological diseases like non-Hodgkin's lymphoma, the development of tumor usually happened within a year. [ 1 – 4 ] If there would be more attention on the association between trauma, and tumorgenesis, early follow-up of the change in the lesion could be achieved. Meanwhile, lack of recognition of this possibility may result in delay of diagnosis and timely treatment.…”

“…Most of the reported cases which had a localized tumor after trauma usually, developed to non-Hodgkin's lymphoma. [ 1 – 4 ] Meanwhile, GS without leukemia, or other myeloproliferative disorders is relatively rare. [ 5 ] Because of the differences, like the average age of onset, and prognosis, nonleukemic GS may be a different category from GS appearing during, or after AML.…”

Physical torment: A predisposition for diffuse B-cell lymphoma

“…[5] PUBMED search revealed about seven cases of malignant lymphoma reported after a history of previous trauma, among those five were reported in head and neck region. [26789] These lymphomas manifested 1–2 months after blunt trauma to the occipital region, cheek, forehead, periorbital and eye.…”