Non-Hodgkin Lymphoma Mimicking Pancreatic Adenocarcinoma and Peritoneal Carcinomatosis

Fukita, Yosho; Asaki, Tsutoshi; Adachi, Seitaro; Yasuda, Ikuma; Toyomizu, Michifumi; Katakura, Yoshiki

doi:10.1200/jco.2012.45.2904

Cited by 11 publications

(9 citation statements)

References 24 publications

(9 reference statements)

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“…CT-guided biopsy and laparotomy have been proposed for obtaining tissue samples. Fine needle aspiration (FNA) through endoscopic ultrasound (EUS) (EUS-FNA) has been a good method to obtain tissue samples through endoscopic ultrasound in recent years (2).…”

Section: Introductionmentioning

confidence: 99%

Primary pancreatic lymphoma: what we need to know

Rad

Khafaf

Alizadeh

2017

J. Gastrointest. Oncol.

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Hodgkin's lymphoma is a group of malignant lymphoid which involve various organs including gastrointestinal tract. Stomach and small intestine are commonly involved more; however, pancreas can be primarily involved as well. The secondary involvement of pancreas caused by Hodgkin's lymphoma is more prevalent than the primarily involvement (1 .25-2.2% .<1%). Primary pancreatic lymphomas (PPLs) consist of 1-2% of all lymphoma outside nods. The symptoms and findings of PPL imaging can be akin to that of pancreas adenocarcinoma and differentiating them is difficult without examining the tissue sample. The prognosis and treatment of PPL are different from those of adenocarcinoma and due to the superior prognosis of PPL compared to pancreas adenocarcinoma, the proper diagnosis of the disease is important.

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Section: Introductionmentioning

confidence: 99%

Primary pancreatic lymphoma: what we need to know

Rad

Khafaf

Alizadeh

2017

J. Gastrointest. Oncol.

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“…Under 0.5% of all pancreatic masses and less than 2% of all extranodal malignant lymphomas are PPLs [11]. Diagnostic criteria of PPL are: (1) mass predominantly within the pancreas with peripancreatic lymphadenopathies; (2) no thoracic or superficial adenopathies, no hepatic or splenic involvement; (3) normal leukocyte count and bone marrow biopsy [12]. Most PPLs are intermediate or high-grade non-Hodgkin's lymphomas, with diffuse large B-cell lymphoma presenting the most common subtype [13].…”

Section: Discussionmentioning

confidence: 99%

A Man with Pancreatic Head Mass Lesion on Endoscopic Ultrasound and Granuloma on Cytopathology

Rad

Heidarnezhad

Soheili

et al. 2016

Case Rep Gastroenterol

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Primary pancreatic lymphoma is an unlikely malignancy accounting for less than 0.5% of pancreatic tumors. Clinical presentation is often nonspecific and may be clinically misdiagnosed as pancreatic adenocarcinoma. Here we present an Iranian case of primary pancreatic lymphoma in a 47-year-old male suffering from jaundice and 20% weight loss. Endoscopic ultrasound revealed a mixed echoic mass lesion at the head of pancreas. The patient underwent endoscopic ultrasound-guided fine needle aspiration of solid pancreatic mass and histopathologic diagnosis revealed granuloma. Computed tomography-guided core needle biopsy was performed and eventually histological examination showed granuloma that was coherent with the diagnosis of primary pancreatic lymphoma. Primary pancreatic lymphoma is a rare entity presenting with nonspecific symptoms, laboratory and radiological findings. Computed tomography results in combination with clinical and radiological studies generally provide guidance for appropriate investigation.

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“…PPL causing dissemination into the peritoneal cavity and omentum (peritoneal lymphomatosis) is an extremely rare and fatal evidence [ 28 ].…”

Section: Atypicalmentioning

confidence: 99%

Secondary Tumors and Lymphoma

Martini¹,

Malagò²,

Capelli³

et al. 2014

Imaging and Pathology of Pancreatic Neoplasms

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Pancreatic metastases are uncommon entities [ 1 , 2 ].Metastases can occur through different ways: by direct invasion, from systemic malignancies such as lymphomas or leukemias, or by metastatic spread from a distant tumor [ 3 ].Primary pancreatic lymphoma is another rare pancreatic neoplasm that accounts for less than 1 % of all pancreatic tumors [ 4 ].Compared to primary pancreatic lymphoma, the secondary involvement of the pancreas by non-Hodgkin's lymphoma is more common and can occur in 30-40 % of patients with extranodal disease [ 5 ]. Secondary Tumors and Lymphoma Pathology MetastasesTumors that directly invade the pancreatic parenchyma generally arise from adjacent structures such as Vater's papilla, extrahepatic bile ducts, stomach, duodenum, or colon [ 6 , 7 ]. Pancreatic involvement by lymphomas and leukemias usually derives from the involvement of peripancreatic lymph nodes; overall, this condition can be seen in up to 30 % of patients with widespread disease [ 8 ].True pancreatic metastases more commonly arise from renal cell carcinoma (which are the most frequent), melanoma, and breast and lung adenocarcinoma [ 2 , 9 , 10 ]. The dissemination route to the pancreas can be either lymphatic or hematogenous; the fi rst is pretty typical for colorectal cancer, due to the unique lymphatic drainage through the mesocolon to the pancreas. In these cases, the most frequent site of implantation of metastases is the inferior portion of the pancreatic head.The exact prevalence of pancreatic metastases is not clear: the reported frequency in autoptic studies ranges between 1.6 and 5.9 % [ 2 , 11 , 12 ], while pancreatic metastases have been observed in 0.7-10.7 % of endoscopic ultrasoundguided fi ne-needle aspirations [ 10 , 12 -14 ].

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Non-Hodgkin Lymphoma Mimicking Pancreatic Adenocarcinoma and Peritoneal Carcinomatosis

Cited by 11 publications

References 24 publications

Primary pancreatic lymphoma: what we need to know

Primary pancreatic lymphoma: what we need to know

A Man with Pancreatic Head Mass Lesion on Endoscopic Ultrasound and Granuloma on Cytopathology

Secondary Tumors and Lymphoma

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