Non-Hodgkin lymphoma in breast: case report

Abstract

The primary breast lymphoma is a rare tumor, accounting for up to 0.5% of breast cancers. Most primary breast lymphoma is presented as non-Hodgkin lymphoma, the B-cells lymphoma is the most common, and Burkitt lymphoma is the most aggressive. We report the case of a 24-year-old female patient, with global, progressive and rapid increase of the right breast during 30 days with reaction to insect bite and progressive weight loss, fatigue, fever and nocturne sweating. An echo-guided core biopsy was held with injury and showed an atypical lymphoid proliferation, suggestive of high-grade non-Hodgkin lymphoma. Immunohistochemistry confirmed non-Hodgkin lymphoma, B immunophenotype, Burkitt type. Also, the diagnosis of HIV infection was performed during hospitalization. Patient started with multidrug chemotherapy scheme and antiretroviral therapy. Burkitt lymphoma is an exceptionally aggressive subtype and can affect the central nervous system and gastrointestinal tract, and treatment consists of chemotherapy with multiple agents as soon as possible. Radiotherapy has no function in the Burkitt type cases, even in case of only local disease. RESUMO

An unusual manifestation of a breast mass: primary lymphoma

“…Some authors showed mean age of 28 years old in 15% of pregnant or lactating women [13]. Clinical manifestations are as B symptoms: fever, weight loss and night sweats [14]. Between 1992 and 2012, 76 patients had the disease symptoms, Its most common feature is a diffuse large B-cell lymphoma(DLBCL)but other subtypes can also be seen [15].…”