Non Hodgkin Lymphoma Among Children: Pathological Aspects and Diagnostic Challenges

Abstract

Non-Hodgkin lymphoma (NHL) are common malignancies in children. Available data on clinico-pathological aspects of pediatric NHL in developping countries are limited and diagnostic approach appears more delicate with absence of molecular studies. The objectives of our study are: analyzing the pathological spectrum of NHL among children and highlighting challenges in the diagnosis including: limited biopsic material; unususal subtyptes, age group, or localization. We retrospectively analyzed clinico pathological characteristics of 101 NHL’s cases among children diagnosed in the Pediatric’s pathology unit over a period of 4 years There were 78 (77.2%) male and 23 (22.8%) female. The median age was 7.2 years. The most common histologic subtypes of NHL were Burkitt lymphoma in 65 patients (64.4% ); followed by lymphoblastic lymphoma in 22 patients, large B-cell lymphoma in 9 patients ( 8.9%); anaplastic T cell lymphoma in 3 patients; NOS mature T cell lymphoma and pediatric type follicular lympoma in 1 patient each. In conclusion, this study Morocco illustrates the pattern of distribution of NHL and emphasizes challenges in the diagnosis of these neoplasms.

Lung microbiome in children with hematological malignancies and lower respiratory tract infections

“…Over the past decades, major advances have been made in therapy for childhood hematological malignancies (1,2), especially acute lymphoblastic leukemia, resulting in obviously higher 10-year survival rates than before (2)(3)(4)(5). However, respiratory infectious complications remain a major cause of morbidity and mortality in the aforementioned children (3,(6)(7)(8).…”