Non-histone protein phosphorylation in normal and neoplastic rat liver chromatin

Comparison of Acidic and Basic Chromosomal Proteins from Normal Human Endometrium and Undifferentiated Endometrial Carcinoma by Isoelectric Focussing and Microgel-Electrophoresis

“…About 4 to 6 differences were noted in chromatin and cytoplasm, out of a total of several hundred separated proteins. This result would imply a conservatism of the non-histone chromosomal proteins comparable to that of the histones, but it is contradicted by the qualitative and quantitative differences in the gel protein patterns of the chromosomal proteins from human endometrium described in this work and in other neoplastic systems (39)(40)(41)(42)(43)(44)(45)(46)(47). Finally, the question must be posed as to whether the methods for high resolution fractionation of chromosomal proteins described in this paper are capable of detecting the gene regulator proteins.…”

Partial fractionation and characterization of nuclear protein kinases in HeLa S3 cells

“…These characteristics include tissue and species specificity [34--36], changes throughout the cell cycle [7,10,37,38], the ability to bind to homologous DNA high rates of turnover, changes correlated with the metabolic state of the cell, and changes in both protein species and degree of phosphorylation induced by a variety of gene-activating stimuli such as hormones [3,6,11,39]. Differences in the phosphorylation of nuclear proteins have also been demonstrated during carcinogenesis [5,40] and viral transformation [41]. More direct evidence for the involvement of nuclear phosphoproteins in the control of gene transcription is suggested by studies concerned with the control of the histone genes in HeLa $3 cells.…”

Phosphorylation of non‐histone chromatin proteins in normal and regenerating rat liver, novikoff hepatoma and rat heart

“…Although the function of these proteins is unknown, they may be associated with the synthetic machinery for production of preribosomal particles. These 32p-incorporating proteins may be related to those previously observed in regenerating liver [2] and in concanavalin A stimulated lymphocytes [19].…”

“…Phosphorylation of non-histone chromatin proteins (NHP) has been related to gene control in numerous cell systems [1][2][3][4][5][6][7]. Phosphorylation of NHP changes with phases of the cell cycle and appears to be correlated with synthesis of RNA and DNA [8,9].…”