“…Helicases are a seemingly ever expanding family of enzymes that catalyze DNA strand separation in a reaction coupled to the binding and hydrolysis of nucleotide triphosphate (NTP) (Matson et al, 1994;Singleton and Wigley, 2002;von Hippel, 2004). A detailed description of the different superfamilies of helicases and their properties is outside the scope of this article, and we refer readers to recent reviews (Lohman et al, 2008;Singleton et al, 2007;von Hippel, 2004). RecQ enzymes are a subfamily of helicases that play an essential role in the maintenance of genome stability by acting at the interface between DNA replication, recombination, and repair Bohr, 2008;Hickson, 2003).…”