Non-Helicobacter pylori Helicobacter Species Associated with Human Disease: a Primer for the Clinical Microbiology Laboratory

Powers-Fletcher, Margaret V.; Couturier, Marc Roger

doi:10.1016/j.clinmicnews.2015.05.004

Cited by 7 publications

(10 citation statements)

References 48 publications

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“…in water samples. Nonpylori Helicobacter species are associated with some human diseases and could exacerbate some situations such as inflammatory bowel disease (IBD), and hepatocellular carcinoma (HCC) (54)(55)(56). Among the ureC positive samples, 18.75% were positive for the cagA gene and the overall detection of cagA gene was 13.51%.…”

Section: Discussionmentioning

confidence: 96%

Detection of Helicobacter pylori in Drinking Water by Loop-Mediated Isothermal Amplification

Abiri

Bagherabadi

Kashef

et al. 2017

Jundishapur J Microbiol

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Background: There should be a public environmental reservoir for Helicobacter pylori in the developing countries, such as Iran, due to their high infection rate of over 70%. Epidemiological findings revealed that water could be a possible source of H. pylori transmission. However, high prevalence of H. pylori in drinking water in Kermanshah, West of Iran, was detected in the authors' previously published study. The current study aims at designing a more accurate and rapid procedure to investigate the prevalence of Helicobacter species and cagA gene in drinking water samples in Kermanshah, from October to December 2012. Methods: In the current study, 60 tap water samples were obtained and specific polymerase chain reaction (PCR) targeted cagA and 16s rRNA was performed. A loop-mediated isothermal amplification (LAMP) targeted ureC gene was developed to accurately detect H. pylori in water samples. Results: The prevalence of ureC by PCR, ureC by LAMP and 16s rRNA by PCR were 26.67%, 38%, and 61.67%, respectively. Among 24 samples (40%), 1 of the 2 tests was positive. The prevalence of cagA gene among ureC positive, 16s rRNA positive and all samples were 18.75%, 13.51%, and 10%, respectively. Conclusions: Helicobacter pylori contamination in drinking water was considerably higher using LAMP compared with PCR. It is noteworthy that some H. pylori positive samples were also positive for Caga.

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Section: Discussionmentioning

confidence: 96%

Detection of Helicobacter pylori in Drinking Water by Loop-Mediated Isothermal Amplification

Abiri

Bagherabadi

Kashef

et al. 2017

Jundishapur J Microbiol

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“…To date, the genus Helicobacter contains about 47 species, with each of the species having a different preference for colonizing different anatomical regions of the host where they incite their pathogenicity [ 3 ]. Although H. pylori has been indicated as the most important species in the genus, infecting an estimated 50% of the global human population, recently, about 23 other species are also reported to be significantly associated with human infections [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence, diversity and public health implications of Helicobacter species in pet and stray dogs

et al. 2022

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“…Apart from H. pylori, there are many other non-H. pylori Helicobacter (NHPH) species which naturally colonise the stomach of a wide range of animals. Some NHPH species have zoonotic potential (4,5) and infections have been associated with a large spectrum of clinical manifestations in humans (4). NHPH infections impose a diagnostic challenge owing to their low prevalence in human patients, their low colonisation density in the human stomach and their fastidious nature hampering cultivation and subsequent species identification (5,6,7).…”

Section: Introductionmentioning

confidence: 99%

Elevated carbohydrate antigen 19-9 following Helicobacter suis gastritis and normalisation after eradication: first case report and review of the literature

Capirchio¹,

Huang²,

Witte³

et al. 2022

AGEB

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Carbohydrate antigen 19-9 (CA 19-9) is a biological marker used to diagnose and monitor the progression of various cancers. Elevated CA 19-9 has also been sporadically observed in Helicobacter pylori infected patients. Similar to H. pylori, animal- hosted non-H. pylori Helicobacter (NHPH) species can induce gastroduodenal lesions in humans. We report the first case of CA 19-9 elevation related to H. suis gastritis and its normalisation after eradication. A CA 19-9 screening prescribed as part of a regular check up by the general practitioner was found elevated in a 68-year-old man presenting chronic dyspeptic symptoms. Medical investigations were negative for presence of neoplasia or biliary obstruction. Upper gastrointestinal endoscopy confirmed the presence of chronic gastritis and H. suis was identified in gastric biopsies. The standard treatment for H. pylori successfully eradicated H. suis with normalisation of CA 19-9 levels. In addition to H. pylori, infection with NHPH species should be considered as an additional cause of elevated CA19-9.

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Non-Helicobacter pylori Helicobacter Species Associated with Human Disease: a Primer for the Clinical Microbiology Laboratory

Cited by 7 publications

References 48 publications

Detection of Helicobacter pylori in Drinking Water by Loop-Mediated Isothermal Amplification

Detection of Helicobacter pylori in Drinking Water by Loop-Mediated Isothermal Amplification

Prevalence, diversity and public health implications of Helicobacter species in pet and stray dogs

Elevated carbohydrate antigen 19-9 following Helicobacter suis gastritis and normalisation after eradication: first case report and review of the literature

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