“…Both the extrinsic and intrinsic factors are there, extrinsic factors are tobacco consumption (both form of tobacco smokeless and with smoke), alcohol, betel quid (paan) and sunlight; and the intrinsic factors are malnutrition, oncogenic viruses, iron deficiency anemia, bacteria, candida, immunosuppression, oncogene and tumour suppressor genes. 9 Few heritable condition like fanconi anemia, 11,12 dyskeratosis congenital 12 sometime associated with OSCC has been reported.…”