Non-HDL-cholesterol to HDL-cholesterol ratio is a better predictor of new-onset non-alcoholic fatty liver disease than non-HDL-cholesterol: a cohort study

Wang, Kun; Shan, Shengshuai; Zheng, Huabo; Zhao, Xiaofang; Chen, Changzhong; Liu, Chengyun

doi:10.1186/s12944-018-0848-8

Cited by 37 publications

(38 citation statements)

References 26 publications

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“…According to the existing study, the NHDLC/HDLC ratio is better than NHDLC in predicting the occurrence of CVD in type 2 DM [10], and the ratio exhibits a higher prediction result than the apoB/apoA1 ratio of the IR and MS [9]. Moreover, as revealed from a perspective cohort study, the NHDLC/HDLC ratio outperforms NHDLC in predicting new-onset NAFLD in Chinese adult population [11]. Therefore, it is necessary to explore the association between the NHDLC/HDLC ratio and NAFLD in the pediatric population.…”

Section: Discussionmentioning

confidence: 98%

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Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study

Yang

Zhong

et al. 2020

Preprint

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Background: The non-HDL cholesterol to HDL cholesterol (NHDLC/HDLC) ratio is closely related to a variety of dyslipidemia-related disease. This study aimed to inspect the relationship between the NHDLC/HDLC ratio and non-alcoholic fatty liver (NAFLD) in childhood and adolescence. Methods: In this cross-sectional survey, a total of 7,759 eligible Chinese children and adolescents (5,692 boys and 2,067 girls) were received routine medical examinations. The anthropometric and laboratory data of the subjects were collected. NAFLD was diagnosed by liver ultrasonography. The binary logistics regression analysis was performed on NHDLC/HDLC ratio, NHDLC and HDLC and NAFLD. ROC curve analysis was exploited to compare the diagnostic significance of the above parameters for NAFLD. Results: The total prevalence of NAFLD was 4.36%, and the prevalence of boys was higher than that of girls (5.61% vs. 1.9%, P < 0.001). The prevalence of NAFLD was positively correlated with the NHDLC/HDLC ratio (P < 0.001). The binary logistics regression analysis demonstrated that the OR was 8.61 (95% CI, 5.90-12.57, P < 0.001) in the tertile 3 (highest NHDLC/HDLC ratio) compared with the tertile 1 (lowest NHDLC/HDLC ratio). When potential confounders (age, sex, BMI, ALT, UA, TB, FPG and HOMA-IR) were adjusted, the OR for the tertile3 (OR=1.83, 95% CI, 1.04-3.22, P = 0.035) was still drastically higher than that of the tertile 1. The AUC of the NHDLC/HDLC ratio of boys was 0.787, which was significantly greater than that of NHDLC and HDLC (0.719 and 0.726, P < 0.001). For girls, the AUC of NHDLC/ HDLC ratio was 0.763, which was also significantly greater than that of NHDLC (0.661, P < 0.001). Furthermore, the cutoff points of NHDLC/HDLC ratio were 2.475 in boys and 2.695 in girls. Conclusions: The NHDLC/HDLC ratio was positively correlated with NALFD in Chinese children and adolescents. It may serve as an effective indicator to help identify NALFD in children and adolescents.

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Section: Discussionmentioning

confidence: 98%

“…Besides, NHDLC/HDLC ratio has a better predictive value for CVD in Type 2 DM than high-density lipoprotein cholesterol (HDLC) [7][8][9][10]. A recent prospective study found that the NHDLC/HDLC ratio is more sensitive to predict NAFLD in adults than non-high-density lipoprotein cholesterol (NHDLC) [11].…”

Section: Introductionmentioning

confidence: 99%

Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study

Yang

Zhong

et al. 2020

Preprint

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“…[15]. A perspective cohort study including 3374 Chinese adults investigated the association between nonHDL-C/HDL-C with NAFLD, with AUROC of 0.717 in women and 0.682 in men [28]. The Jinchang Cohort study consisting of 32,121 subjects, evaluated the ability of TC/HDL-C for identifying NAFLD, and the results suggested the AUC of TC/HDL-C was 0.645 [16].…”

Section: Discussionmentioning

confidence: 99%

Triglycerides to Total Cholesterol Ratio: An Early Screening Tool for NAFLD in Chinese Populations

Chen

Yang

Wang

et al. 2020

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Background: Non-alcoholic fatty liver disease(NAFLD) has a high prevalence in the general population worldwide. Both triglycerides (TG) and total cholesterol (TC) are correlated with the prevalence of NAFLD. The study purpose is to determine whether TG/TC is an effective method to screen NAFLD in the general Chinese population.Methods: 93,449 subjects with average age of 43.7 ± 14.3 years were included in this cross-sectional study. Multiple logistic regressions and receiver operator characteristic curve (ROC) analyses were performed.Results: Among these subjects, 16,138 (42.7%) men and 9,591 (17.2%) women were diagnosed with NAFLD. Subjects in the higher quartiles of TG/TC had a higher prevalence of NAFLD. After adjusting multiple confounding factors, the odds ratio (OR) for NAFLD in the highest compared with the lowest quartile was 4.08 (95%CI 3.64, 4.57) in men and 4.65 (95%CI 4.14, 5.21) in women. Moreover, ROC analyses suggested TG/TC showed high diagnostic ability for detecting NAFLD, and the areas under the curves (AUC) in men and women were 0.920 (95%CI 0.917, 0.923) and 0.863 (95%CI 0.859, 0.867), respectively. Furthermore, the diagnostic ability was significantly higher in younger age groups. The AUC in 18–34 and 35–44 years group were 0.943 (95%CI 0.939, 0.946) and 0.921 (95%CI 0.917, 0.925), respectively. Besides, the women and the young people had a greater negative predictive values (90.84% for women, 93.13% for aged 18–34).Conclusion: TG/TC shows a high diagnostic accuracy for identifying NAFLD in young women, providing an important clue to establish a new tool to screen NAFLD particularly in Chinese young females.

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“…Existing studies reported that non-HDL-c/HDL-c rate more effectively predicts CVD in type 2 diabetes than non-HDL-c [11], and the ratio exhibits higher predictive value than the apoB/apoA1 rate in terms of insulin resistance and MS [8]. Moreover, as revealed from a perspective cohort study, non-HDL-c/HDL-c rate outperforms non-HDL-c in predicting new-onset NAFLD in Chinese adult population [11]. Thus, the associations of the non-HDL-c/HDL-c rate and the risk of NAFLD among children and adolescence should be explored.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, The non-HDLc/HDL-c rate is an independent risk factor of chronic kidney disease and gallbladder polyp, and it is an ideal marker for insulin resistance and metabolic syndrome [8][9][10]. As revealed from a perspective cohort study, non-HDL-c/HDL-c rate can more noticeably predict new-onset NAFLD than Non-HDL-c among adults [11]. However, the association between the non-HDL-c/HDL-c ratio and NAFLD among pediatric population remians unknown.…”

Section: Introductionmentioning

confidence: 99%

Association of the Non-HDL-cholesterol to HDL-cholesterol Rate and the Risk of Non-alcoholic Fatty Liver Disease Among Children and Adolescence: A Retrospective Cohort Study

Yang¹,

Zhong²,

Ye³

et al. 2020

Preprint

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Background: The non-HDL-cholesterol to HDL-cholesterol (non-HDL-c/HDL-c) rate shows a close relationship to multiple dyslipidemia related disease. This paper aims at investigating the association of the non-HDL-c/HDL-c rate and the risk of NAFLD among children and adolescence in China.Methods: In this retrospective cohort study, a total of 7759 eligible children and adolescence (5692 boys, 2067 girls) having received regular medical examination were recruited. We collected anthropometric measurements and laboratory tests data of subjects. The binary logistics regression was employed for the assessment of the associations of the non-HDL-c/HDL-c rate with NAFLD. Sex-specific ROC curve analysis was conducted for comparing the predictive value of non-HDL-c/HDL-c rate, non-HDL-c and HDL-c for NAFLD.Results: The total NAFLD prevalence was 4.36%, higher in boys than that in girls (5.61% vs. 1.9%, P<0.001). It is noteworthy that NAFLD prevalence displayed positive correlation with the non-HDL-c/HDL-c rate（Chi-square test, P<0.001). The binary logistics regression analysis shows that the OR were 8.61 (95% CI = 5.90-12.57, P< 0.001) in the maximum tertiles (maximum non-HDLc/HDLc ratio) compared with the minimum tertiles. When potential confounders were regulated, compared with the minimum tertiles, the OR for the maximum tertiles (OR=3.94, 95%CI=2.33-6.66, P< 0.001) was still significantly higher. AUC values of the non-HDL-c/HDL-c rate ( 0.787 in boys and 0.763in girls) noticeably reached over non-HDL-c (0.719 in boys and 0.661 in girls) and HDL-c (0.726 in boys and 0.732 in girls). Furthermore, the optimal cutoff value of the non-HDL-c/HDL-c rate for NAFLD was 2.475 in boys and 2.695 in girls.Conclusions: The present study indicate that a higher non-HDL-c/ HDL-c rate caused a higher risk of NAFLD among children and adolescence. Moreover, the non-HDL-c/HDL-c rate showed a better predictive value for NAFLD than the non-HDL-c and HDL-c in both boys and girls.

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Non-HDL-cholesterol to HDL-cholesterol ratio is a better predictor of new-onset non-alcoholic fatty liver disease than non-HDL-cholesterol: a cohort study

Cited by 37 publications

References 26 publications

Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study

Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study

Triglycerides to Total Cholesterol Ratio: An Early Screening Tool for NAFLD in Chinese Populations

Association of the Non-HDL-cholesterol to HDL-cholesterol Rate and the Risk of Non-alcoholic Fatty Liver Disease Among Children and Adolescence: A Retrospective Cohort Study

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