Non-hazardous anticancerous and antibacterial colloidal ‘green’ silver nanoparticles

Barua, Shaswat; Konwarh, Rocktotpal; Bhattacharya, Suvendu; Das, P.; Devi, K. Sanjana P.; Maiti, Tapas K.; Mandal, Manabendra; Karak, Niranjan

doi:10.1016/j.colsurfb.2012.12.015

Cited by 90 publications

(58 citation statements)

References 24 publications

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“…Goix et al 33 and Boholm and Arvidsson 34 have pointed out that silver is either beneficial or harmful in relation to four main values: the environment, health, sewage treatment, and product effectiveness. As reported by Barua et al 35 poly(ethylene glycol)-stabilized colloidal SNPs showed the nonhazardous anticancer and antibacterial properties. Jin et al 36 have reported the therapeutic applications of plant-extract-based scaffolds for wound healing and skin reconstitution studies.…”

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confidence: 72%

Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles

Arunachalam¹,

Arun²,

Annamalai³

et al. 2014

IJN

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Background Gymnema sylvestre is an ethno-pharmacologically important medicinal plant used in many polyherbal formulations for its potential health benefits. Silver nanoparticles (SNPs) were biofunctionalized using aqueous leaf extracts of G. sylvestre . The anticancer properties of the bioactive compounds and the biofunctionalized SNPs were compared using the HT29 human adenoma colon cancer cell line. Methods The preliminary phytochemical screening for bioactive compounds from aqueous extracts revealed the presence of alkaloids, triterpenes, flavonoids, steroids, and saponins. Biofunctionalized SNPs were synthesized using silver nitrate and characterized by ultraviolet–visible spectroscopy, scanning electron microscopy, energy-dispersive X-ray analysis, Fourier transform infrared spectroscopy, and X-ray diffraction for size and shape. The characterized biofunctionalized G. sylvestre were tested for its in vitro anticancer activity against HT29 human colon adenocarcinoma cells. Results The biofunctionlized G. sylvestre SNPs showed the surface plasmon resonance band at 430 nm. The scanning electron microscopy images showed the presence of spherical nanoparticles of various sizes, which were further determined using the Scherrer equation. In vitro cytotoxic activity of the biofunctionalized green-synthesized SNPs (GSNPs) indicated that the sensitivity of HT29 human colon adenocarcinoma cells for cytotoxic drugs is higher than that of Vero cell line for the same cytotoxic agents and also higher than the bioactive compound of the aqueous extract. Conclusion Our results show that the anticancer properties of the bioactive compounds of G. sylvestre can be enhanced through biofunctionalizing the SNPs using the bioactive compounds present in the plant extract without compromising their medicinal properties.

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confidence: 72%

Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles

Arunachalam¹,

Arun²,

Annamalai³

et al. 2014

IJN

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“…Today we talk of "Green Nanotechnology" and "nanotoxicology" as two important areas of research on nanomaterials. A report showed that colloids of silver nanoparticles supported on biopolymers, stabilize nanoscale particles, making them minimally toxic and maintaining their antimicrobial activity, which has profound biomedical implications (Barua et al, 2013). Cu2O nanoparticles were prepared, using agricultural waste Arachis hypogaea (peanuts), leaf extracts containing reducing sugars, which act as reducing agent at room temperature (Ramesh et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Copper Nanoparticles as Potential Antimicrobial Agent in Disinfecting Root Canals: A Systematic Review

Sánchez‐Sanhueza

Fuentes‐Rodríguez

Bello-Toledo

2016

Int. J. Odontostomat.

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ABSTRACT:Copper was registered as the first solid antimicrobial material. Its availability makes it an important option as an antibacterial agent. At nanoparticle size it does not exceed 100 nm, allowing close interaction with microbial membranes, enhancing its effect even more. Copper generates toxic hydroxyl radicals that damage cell membranes of Gram-negative and Gram-positive bacteria, among the latter, Enterococcus faecalis, which are present in infected radicular canals. Synthesis of metal nanoparticles with antimicrobial properties has become a viable alternative and has promising applications in the fight against pathogenic microorganisms. Furthermore, the use of some polymers to stabilize nanoparticles increases their release time and may as well decrease the risk of bacterial recolonization and biofilm formation within the ducts, enhancing the antimicrobial properties of these compounds.The aim of this article is to conduct a systematic review of the literature on antimicrobial copper nanoparticles, their current applications and their potential use in the area of oral health, specifically in the field of endodontics.

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“…Green method of synthesizing nanoparticles with plant extracts is advantageous over physical, chemical and microbial methods as it is simple, convenient, environment friendly and requires less reaction time [9]. Among the noble metals used in green synthesis, silver is widely preferred owing to its antibacterial [10], antifungal, larvicidal, antiparasitic [11] and anticancer [12] properties. In green synthesis capping and stabilization of silver nanoparticles are brought about by bioactive compounds like alkaloids, flavonoids and polyphenols present in plant extracts [13].…”

Section: Introductionmentioning

confidence: 99%

Catalytic and biological activities of green silver nanoparticles synthesized from Plumeria alba (frangipani) flower extract

Mata

Nakkala

Rani

2015

Materials Science and Engineering: C

101

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Non-hazardous anticancerous and antibacterial colloidal ‘green’ silver nanoparticles

Cited by 90 publications

References 24 publications

Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles

Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles

Copper Nanoparticles as Potential Antimicrobial Agent in Disinfecting Root Canals: A Systematic Review

Catalytic and biological activities of green silver nanoparticles synthesized from Plumeria alba (frangipani) flower extract

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