Non-genetic messenger RNA silencing reveals essential genes in phage-host interplay
Milan Gerovac,
Svetlana Ðurica-Mitić,
Leandro Buhlmann
et al.
Abstract:Bacteriophages are the most abundant entities on earth and exhibit vast genetic and phenotypic diversity. Exploitation of this largely unexplored molecular space requires identification and functional characterisation of genes that act at the phage-host interface. To date, this is restricted to few model phage-host systems that are amenable to genetic manipulation. To overcome this limitation, we introduce a non-genetic mRNA targeting approach using exogenous delivery of programmable antisense oligomers (ASOs)… Show more
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