Non-Genetic Leuko-Neutropenia Is Related to Dietary Cholesterol: An Experimental Model with the Rat

Ogunranti, J. O.

doi:10.1159/000204176

Cited by 1 publication

(2 citation statements)

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“…Our finding that low cholesterol level is found in neutropenic patients is in line with previous literature . High cholesterol diet increased total white blood cell count and neutrophil percentage in rats .…”

Section: Discussionsupporting

confidence: 93%

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Patient characteristics associated with peglyated interferon alfa‐2a induced neutropenia in chronic hepatitis C patients

Hindi

Saleh

2018

Clin Exp Pharma Physio

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Neutropenia is a haematologic disorder commonly reported in patients with chronic hepatitis C virus (HCV) infection treated with pegylated interferon alfa-2a (PEG-IFN α-2a). The objective of the present project is to identify patient characteristics associated with neutropenia in hepatitis C patients. Demographic, clinical, and genetic data from 715 patients with chronic HCV infection treated with PEG-IFN α-2a and ribavirin. The outcome variable was the development of grade 3 or 4 neutropenia, defined as the decrease in neutrophil counts below 1 10 /L anytime during study. Predictors of neutropenia were identified using a 2-stage approach. First, univariate analysis was performed to identify possible predictors of neutropenia. T test was used for continuous variables and Fisher's exact test was used for categorical variables. Second, multiple logistic regression with stepwise addition was then performed using predictors identified in the univariate analysis step to produce final model containing independent predictors at P < .05. Logistic regression identified female gender, absolute neutrophils counts, and cholesterol level as the main predictors of neutropenia. Female gender increases the odds of experiencing neutropenia by 86% compared to male gender. A 1 unit (mmol/L) increase in cholesterol level decreases the odds of developing neutropenia by 13%. A 55% reduction in the likelihood of developing neutropenia for a 1 unit (10 /L) increase in the absolute neutrophils counts. Patients with high risk of developing neutropenia can be identified. Identification of this cohort allows early intervention to prevent neutropenia. Possible intervention is to administer drugs that raise neutrophil count such as filgrastim before neutropenia occurs.

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Section: Discussionsupporting

confidence: 93%

“…High cholesterol diet increased total white blood cell count and neutrophil percentage in rats . In fact, injecting pure cholesterol increased neutrophils count in rats within 6 hours . Gomes et al.…”

Section: Discussionmentioning

confidence: 94%