Non‐gaussian diffusion‐weighted imaging for assessing diurnal changes in intervertebral disc microstructure

Katsura, Masaki; Suzuki, Yuichi; Hata, Junichi; Hori, Masaaki; Sasaki, Hiroki; Akai, Hiromu; Mori, Hiromu; Kunimatsu, Akira; Masutani, Yoshitaka; Aoki, Shigeki; Ohtomo, Kuni

doi:10.1002/jmri.24459

Cited by 10 publications

(13 citation statements)

References 26 publications

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“…whereas that involving FWHM is not influenced. 13,31 In particular, an increase in the ADC indicates a decrease in fluid viscosity in the tissue and spatial dilatation of the space in which water molecules can move. 31 In contrast, FWHM reflects the space in which water molecules can actually move, 16,32 and thus, water molecule diffusion restricted by the ECM network might be more accurately represented with FWHM than with ADC.…”

Section: Discussionmentioning

confidence: 99%

“…33 The usefulness of Kurtosis, including diffusion Kurtosis imaging (DKI), for evaluating IVD degeneration has been reported by several researchers. 13,34 In a clinical study, Katsura et al 13 showed that DKI can detect IVD diurnal microstructural changes. Li et al 34 showed that DKI can distinguish between grade 1 and 2 in Pfirrmann classification using normal rats.…”

Section: Discussionmentioning

confidence: 99%

“…8,11,12 However, as conventional DWI is based on the theory that water molecules follow Gaussian distribution, the ADC does not accurately represent the phenomenon of human tissues in which water molecules diffuse according to non-Gaussian distribution. 13 Therefore, other approaches that are not based on Gaussian distribution are required to exclude as many factors as possible that affect the signal in DWI. Additionally, a new method for the evaluation of IVD degeneration has been expected because the evaluation using T2WI and ADC was inadequate.…”

Section: Introductionmentioning

confidence: 99%

“…16 QSI has been reported to reflect the microstructure of tissues in vivo without assuming Gaussian distribution for the underlying probability density function (PDF) of water molecule diffusion. 13,17,18 In addition, it has been shown to provide the following additional diffusion values: Kurtosis (arbitrary unit [a.u. ]), full width at half maximum (FWHM, µm), and probability at zero displacement (ZDP, a.u.).…”

Section: Introductionmentioning

confidence: 99%

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Quantitative analysis of intervertebral disc degeneration using Q‐space imaging in a rat model

Nakashima

Fujita

Hata

et al. 2020

Journal Orthopaedic Research

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The degree of intervertebral disc (IVD) degeneration is qualitatively evaluated on T2‐weighted imaging (T2WI). However, it is difficult to assess subtle changes in IVD degeneration using T2WI. Q‐space imaging (QSI) is a quantitative diffusion‐weighted imaging modality used to detect subtle changes in microenvironments. This study aimed to evaluate whether QSI can detect the inhibitory effects of the antioxidant N‐acetylcysteine (NAC) in IVD degeneration. We classified female Wistar rats into control, puncture, and NAC groups (n = 5 per group). In the puncture and NAC groups, IVDs were punctured using a needle. The antioxidant NAC, which suppresses the progression of IVD degeneration, was orally administered in the NAC group 1 week prior to puncture. The progression and inhibitory effect of NAC in IVD degeneration were assessed using magnetic resonance imaging (MRI): IVD height, T2 mapping, apparent diffusion coefficient (ADC), and QSI. MRI was performed using a 7‐Tesla system with a conventional probe (20 IVDs in each group). QSI parameters that were assessed included Kurtosis, the probability at zero displacement (ZDP), and full width at half maximum (FWHM). IVD degeneration by puncture was confirmed by histology, IVD height, T2 mapping, ADC, and all QSI parameters (P < .001); however, the inhibitory effect of NAC was confirmed only by QSI parameters (Kurtosis and ZDP: both P < .001; FWHM: P < .01). Kurtosis had the largest effect size (Kurtosis: 1.13, ZDP: 1.06, and FWHM: 1.02) when puncture and NAC groups were compared. QSI has a higher sensitivity than conventional quantitative methods for detecting the progressive change and inhibitory effect of NAC in IVD degeneration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quantitative analysis of intervertebral disc degeneration using Q‐space imaging in a rat model

Nakashima

Fujita

Hata

et al. 2020

Journal Orthopaedic Research

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“…DTI is based on the assumption that water molecules follow Gaussian distribution. In human tissues, however, water molecules diffuse according to a non-Gaussian distribution [10].…”

Section: Introductionmentioning

confidence: 99%

iShim and Water Excitation Improves the Signal-to-Noise Ratio on q-Space Imaging: A Single-Center Clinical Study

Sone¹,

Hata²,

Sera³

et al. 2018

OJRad

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Purpose: This study aimed to examine whether the signal-to-noise ratio (SNR) could be increased by combining integrated slice-by-slice shimming (iShim) with a fat suppression (FS) method other than short-tau inversion recovery (STIR) in diffusion-weighted imaging (DWI) and q-space imaging (qsi). Methods: We acquired DWI images (b-values: 0 and nine steps from 400 to 10,000 s/mm 2 for six axes) using a prototypical single-shot echo planar imaging sequence by combining two types of shimming (3D Shim and iShim) and two types of FS (STIR and water excitation [WE]) in 10 volunteers. In the DWI study, the SNR for each b-value, FS effect in the b0 image, and distortion in the added image (b0-b10,000) were evaluated for the above-mentioned four imaging methods. qsi involved original DWI images. In the qsi study, the SNR was evaluated. Results: With regard to both 3D Shim and iShim, the SNRs were significantly higher when using WE than when using STIR in b0-b900 images (p < 0.01). For 3D Shim, however, the SNR increase effect of WE disappeared (p < 0.01) at b1600 or higher. For iShim, the SNR increase effect of WE was maintained up to b3600 (p < 0.01). The FS effect of STIR was superior to that of WE (p < 0.01). Although WE had a weak FS effect, its FS effect was greater with iShim than with 3D Shim (p < 0.01). In added images, with iShim, the spinal cord area became significantly smaller (p < 0.

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Zusammenhang zwischen der Schmerzreduktion nach Manualtherapie an der Lendenwirbelsäule und Wassereinstrom in die Bandscheiben

Ammer¹

2014

Manuelle Medizin

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Non‐gaussian diffusion‐weighted imaging for assessing diurnal changes in intervertebral disc microstructure

Abstract: The RMSD and AKC values obtained from QSI analysis may be biomarkers for IVD diurnal microstructural changes.

Cited by 10 publications

References 26 publications

Quantitative analysis of intervertebral disc degeneration using Q‐space imaging in a rat model

Quantitative analysis of intervertebral disc degeneration using Q‐space imaging in a rat model

iShim and Water Excitation Improves the Signal-to-Noise Ratio on q-Space Imaging: A Single-Center Clinical Study

Zusammenhang zwischen der Schmerzreduktion nach Manualtherapie an der Lendenwirbelsäule und Wassereinstrom in die Bandscheiben

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