Non-functioning, malignant pancreatic neuroendocrine tumour (PNET): a rare entity during pregnancy

Kamphues, Carsten; Röcken, Christoph; Neumann, Ulf

doi:10.1007/s00423-008-0346-y

Cited by 8 publications

(3 citation statements)

References 20 publications

(25 reference statements)

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“…We believe this case is the first pancreatic NET reported in pregnancy presenting with upper gastrointestinal bleeding from varices consequent of splenic vein invasion. There have been three documented cases of PNETs in pregnancy [ 17 , 18 ]. These cases describe tumours diagnosed before 20-week gestation and resected antepartum with successful delivery at term in two of the three cases.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Aetiology for Massive Upper Gastrointestinal Haemorrhage in Pregnancy

Zaborowski

Walsh

Ravi

et al. 2016

Case Reports in Surgery

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We present herein what we believe is the first reported case of massive upper gastrointestinal bleeding in pregnancy due to a pancreatic neuroendocrine tumour causing left sided portal hypertension. A 37-year-old 27-week pregnant female presented with massive haematemesis and melaena requiring transfusion of 10 units of red cell concentrate. Gastric varices were evident at endoscopy. An MRI revealed a large mass infiltrating the pancreatic tail and spleen with massive upper abdominal varix formation secondary to splenic vein invasion. A caesarean section was performed, followed by a radical en bloc partial pancreatectomy and splenectomy with resection of the fundus of the stomach and ligation of gastric and splenic varices. Her postoperative course was uncomplicated. Histology revealed a well differentiated grade 2 neuroendocrine tumour with final staging of T4N0. This case highlights an infrequently encountered cause of massive gastrointestinal bleeding. Diagnosis and management of pancreatic neuroendocrine tumours, due to their rarity and variable clinical presentation, can be challenging particularly in the setting of pregnancy where the wellbeing of a second patient must also be considered. A multidisciplinary approach with input from obstetricians and general surgeons is required when deciding optimum management, while also taking into account the patient's preferences.

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Section: Discussionmentioning

confidence: 99%

Pancreatic Aetiology for Massive Upper Gastrointestinal Haemorrhage in Pregnancy

Zaborowski

Walsh

Ravi

et al. 2016

Case Reports in Surgery

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“…[23] These should be resected during pregnancy if they are causing IUGR or other problems due to size. [22]…”

Section: Discussionmentioning

confidence: 99%

“…There have been only eight reported cases of pancreatic adenocarcinoma,[1–8] thirteen cases of cystic pancreatic lesions diagnosed during pregnancy,[9–21] and three reported cases of pancreatic neuroendocrine tumors. [22, 23] Their occurrence during pregnancy leads to dilemmas in diagnosis, management, and timing of surgical treatment. In all cases the goal is to minimize both maternal and fetal risk.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic Neoplasms in Pregnancy: Diagnosis, Complications, and Management

Boyd

Benarroch‐Gampel

Kılıç

et al. 2012

Journal of Gastrointestinal Surgery

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BACKGROUND Neoplasms of the pancreas during pregnancy are rare, with less than 25 cases of benign and malignant tumors reported in the literature. METHODS We present three unique cases of pancreatic tumors occurring during pregnancy—one mucinous cystic neoplasm and two adenocarcinomas. We review the literature regarding pancreatic neoplasms during pregnancy and discuss the diagnosis, complications, and management of these tumors. RESULTS MRI and ultrasound are the imaging modalities of choice in pregnancy. In patients with benign or premalignant tumors, surgical resection may be postponed until the second trimester. In symptomatic patients, or if there is a concern for intrauterine growth restriction (IUGR), urgent surgical intervention should be performed. With malignant tumors, the benefit of delaying surgery must be balanced with the risk of maternal disease progression. Termination of the pregnancy should be discussed when a malignant tumor is diagnosed during the first trimester. Pancreatic tumors diagnosed during the third trimester may be resected after delivery. If malignant, early delivery of the fetus and subsequent maternal operation can be considered at appropriate fetal maturity. CONCLUSION When these tumors occur during pregnancy, they present a diagnostic and treatment dilemma, with variation in treatment based on gestational age and patient preference.

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Gastrointestinal malignancies in pregnancy

et al. 2023

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Non-functioning, malignant pancreatic neuroendocrine tumour (PNET): a rare entity during pregnancy

Abstract: Although PNETs are extremely rare, this entity can be confirmed as another differential diagnosis for suspicious pancreatic mass during pregnancy. In specialized centres, these tumours can be removed without any harmful consequences to the foetus.

Cited by 8 publications

References 20 publications

Pancreatic Aetiology for Massive Upper Gastrointestinal Haemorrhage in Pregnancy

Pancreatic Aetiology for Massive Upper Gastrointestinal Haemorrhage in Pregnancy

Pancreatic Neoplasms in Pregnancy: Diagnosis, Complications, and Management

Gastrointestinal malignancies in pregnancy

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