The lack of material characteristic length scale prevents classical continuum theory (CCT) from recognizing size effect. Additionally, the even‐order material property tensors associated with CCT only characterize the materials' centrosymmetric behavior and overlook their intrinsic chirality and polarity. Moreover, CCT is not reducible to 2D and 1D space without adding couples and higher‐order deformation gradients. Despite several generalized continuum theories proposed over the past century to overcome the limitations of CCT, the broad application of these theories in the field of mechanical metamaterials has encountered significant challenges. These obstacles primarily arise from a limited understanding of the material coefficients associated with these theories, impeding their widespread adoption. Implementing a bottom‐up approach based on augmented asymptotic homogenization, a consistent and self‐sufficient effective couple‐stress theory for materials with microstructures in 3D, 2D, and 1D spaces is presented. Utilizing the developed models, material properties associated with axial‐twist, shear‐bending, bending‐twist, and double curvature bending couplings in mechanical metamaterials are characterized. The accuracy of these homogenized models is investigated by comparing them with the detailed finite element models and experiments performed on 3D‐printed samples. The proposed models provide a benchmark for the rational design, classification, and manufacturing of mechanical metamaterials with programmable coupled deformation modes.