Abstract:One of the key factors limiting sensitivity in many
electrochemical assays is the non-faradaic or capacitive current. This is particularly true in modern assay
systems based on DNA monolayers at gold electrode surfaces, which have shown
great promise for bioanalysis in complex milieu such as whole blood or serum. While various changes in analytical parameters,
redox reporter molecules, DNA structures, probe coverage, and electrode surface
area have been shown useful, background reduction by hardware subtract… Show more
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