Non-enzymatic sensing of glucose using a glassy carbon electrode modified with gold nanoparticles coated with polyethyleneimine and 3-aminophenylboronic acid

Çiftçi, Hakan; Alver, Erol; Dadaşer-Çelik, Filiz; Metin, Ayşegül Ülkü; Tamer, Uğur

doi:10.1007/s00604-016-1782-y

Cited by 41 publications

(6 citation statements)

References 33 publications

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“…[23] Hakan Ciftci et al modified GCE with AuNPs coated with polyethyleneimine and APBA to detect glucose with a detection limit of 0.025mM. [24] Here, we report a novel label-free, non-enzymatic glucose biosensor developed with a cost-effective working wireelectrode that has the potential to continuously monitor glucose concentrations. The novel carbon paste wire-electrode (CPE) was fabricated with the help of ingeniously developed carbon paste utilizing a facile methodology.…”

Section: Introductionmentioning

confidence: 95%

Facile, Label‐Free, Non‐Enzymatic Electrochemical Nanobiosensor Platform as a Significant Step towards Continuous Glucose Monitoring

2021

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The paper proposes a low‐cost, facile methodology to develop a non‐enzymatic glucose sensor by utilizing the inherent affinity of Boronic Acid moieties towards glucose along with the enhanced electrochemical activity of gold nanoparticles (AuNPs). The AuNPs were electrochemically deposited onto the surface of the indigenous carbon paste wire electrodes to enhance both the active area and the kinetics of the electrodes, thereby increasing the sensitivity of the detection. The sensitivity and limit of detection of the proposed biosensor, as established using Differential Pulse Voltammetry (DPV) and Electrochemical Impedance Spectroscopy (EIS), was found to be 0.0254 [(μA/(mg/dL))/mm2] and 0.085 mg/dL, respectively. The interference and selectivity studies with the most common interference species, such as acrylic acid, uric acid, and salicylic acid, plasma, NaCl, and KCl, carried out resulted in negligible interference. The bio‐electrodes also showed excellent stability and shelf‐life, making them a potential candidate for non‐enzymatic glucose monitoring.

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Section: Introductionmentioning

confidence: 95%

Facile, Label‐Free, Non‐Enzymatic Electrochemical Nanobiosensor Platform as a Significant Step towards Continuous Glucose Monitoring

2021

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“…AuNPs coated with polyethyleneimine (PEI) and 3-aminophenyl boronic acid, which were previously synthesized for another study, were used in our work. [26] AuNPs were added and provided the same concentration of gold nanoparticles in the culture during irradiation.…”

Section: Aunp Synthesismentioning

confidence: 99%

Radiation Enhancement with Polyethyleneimine-Coated Gold Nanoparticles Under MV Photons

Arslan¹

2020

TJ Oncol

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OBJECTIVERadiotherapy is an essential part of cancer management, and about two-thirds of the patients with cancer receive radiation therapy during their treatment. The healthy structures around the tumor are dose limiting in terms of acute and late toxicity. Radiosensitizers (RSs) can be used to enhance intratumoral dose, thus improving the therapeutic ratio. We aimed to investigate the cytotoxicity on normal and cancer cell lines induced by interaction between MV photon irradiation and polyethyleneimine (PEI)coated gold nanoparticles (AuNPs). METHODSThe effects of different concentrations of AuNPs (0.75 µg/ml, 0.5 µg/ml, 0.25 µg/ml, and only medium) and 2 Gy ionizing radiation (IR) were investigated on the L929 fibroblast, DLD-1 colon, and H1299 lung cancer cell lines. Cytoplasmic and nuclear membranes treated with hematoxylin and eosin and double staining were evaluated with light and fluorescence microscopy. Cytotoxicity was determined with the WST-1 method. RESULTSAll particles were spherical in shape with 60.98 nm in size. Cell surviving ratios without AuNPs were 96.34% in L929, 89.68% in DLD-1, and 76.93% in H1299 for a single 2-Gy radiation. These ratios were 94.2%, 62.58%, and 40.52% for L929 cells; 72.70%, 41.15%, and 26.71% for DLD-1 cells; and 34.72%, 28.27%, and 17.84% for H1299 cells at concentrations of 0.25 µg/ml, 0.5 µg/ml, and 0.75 µg/ml AuNPs, respectively. CONCLUSIONAt increased concentrations, isolated unwanted cytotoxic effects of AuNPs could be observed. Radiosensitizing effect of PEI-coated AuNPs depends on cell type and AuNP concentration.

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“…7 All these analytical parameters can be attained in a single electrode by modification of the existing electrodes with conducting polymer-metal nanoparticles composites. 8 In such composites, the role of conducting polymer is to provide mechanical stability and high conductivity while the dispersion of metal nanoparticles is responsible for the catalytic action of the sensor. Conducting polymers such as polyaniline (PANI), poly(o-phenylenediamine) (PoPD), polythiophenes, poly(3, 4-ethylenedioxythiophene) (PEDOT), polyvinylferrocenium, and polypyrrole (PPY) have been researched in the fabrication of ideal sensors.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, Au particles have advanced biocompatibility, anti-poising characteristic and wide range of oxidation potential. 8 Herein, we report the development of amperometric non-enzymatic sensor with electrodeposition of Au particles on PANI film modified Pt electrode for detection of glucose. The Au particles were electrodeposited from KAuCl 4 solution.…”

Section: Introductionmentioning

confidence: 99%

Amperometric Enzyme-Free Glucose Sensor Based on Electrodeposition of Au Particles on Polyaniline Film Modified Pt Electrode

Malhotra

Tang

Varshney

2018

ACSi

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An amperometric non-enzymatic glucose sensor of high sensitivity was developed by modification of Pt electrode with electrodeposition of Au particles on polyaniline film. The Au particles were deposited under optimum growth conditions for maximum dispersion on polymer film to achieve highly sensitive glucose sensor. The characterization of the electrode and the analytical parameters were evaluated using chronoamperometry and cyclic voltammetry techniques. The sensor showed wide linear range from 0.01-8 mM along with swift response time of less than 5 s. Moreover, a high sensitivity of 113.6 µA mM-1 cm-2 is obtained along with low detection limits of 0.5 µM. The sensor also showed high stability, reproducibility, and repeatability. Furthermore, the sensor has shown high selectivity towards glucose exclusively in the presence of interferents such as sucrose, uric acid, and ascorbic acid. The practical applicability of the proposed sensor was confirmed from successful analysis of glucose in different juice samples and these results were comparable to the commercial glucose meter. Thus, our sensor stands promising non-enzymatic sensor for routine analysis of glucose.

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Non-enzymatic sensing of glucose using a glassy carbon electrode modified with gold nanoparticles coated with polyethyleneimine and 3-aminophenylboronic acid

Cited by 41 publications

References 33 publications

Facile, Label‐Free, Non‐Enzymatic Electrochemical Nanobiosensor Platform as a Significant Step towards Continuous Glucose Monitoring

Facile, Label‐Free, Non‐Enzymatic Electrochemical Nanobiosensor Platform as a Significant Step towards Continuous Glucose Monitoring

Radiation Enhancement with Polyethyleneimine-Coated Gold Nanoparticles Under MV Photons

Amperometric Enzyme-Free Glucose Sensor Based on Electrodeposition of Au Particles on Polyaniline Film Modified Pt Electrode

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