Non-enzymatic oxidation of NADH by quinones

Scherbak, Nikolai; Strid, Åke; Eriksson, Leif A.

doi:10.1016/j.cplett.2005.08.067

Cited by 14 publications

(15 citation statements)

References 19 publications

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“…compounds were characterized by microanalysis and spectroscopic data, containing FT-IR, 1 H NMR, 13 C NMR, MS, and UV-vis spectroscopy…”

Section: Resultsmentioning

confidence: 99%

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The synthesis of new cyclic thioquinone derivatives

Ibis¹,

Özsoy-Güneş²

2010

Heteroatom Chemistry

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“…compounds were characterized by microanalysis and spectroscopic data, containing FT-IR, 1 H NMR, 13 C NMR, MS, and UV-vis spectroscopy…”

Section: Resultsmentioning

confidence: 99%

“…The ability to carry electrons makes them an important component of photosynthetic and respiratory electron transfer chain [1]. Quinonic compounds are of great importance to understand different processes that are related to biology [2].…”

Section: Introductionmentioning

confidence: 99%

The synthesis of new cyclic thioquinone derivatives

Ibis¹,

Özsoy-Güneş²

2010

Heteroatom Chemistry

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“…The approaches used for solving these problems include chemical redox mediators [11,[13][14][15][16][17][18] or enzymes [11,19,20] that catalyze electron transfer, thus enabling low-potential measurements and/or protection on the electrode surface from fouling. New materials for electrode manufacture that will enable efficient NADH oxidation are constantly being sought [21,22], among them carbon nanotubes [23].…”

Section: Nadh Detectionmentioning

confidence: 99%

Carbon nanotubes based electrochemical biosensor for detection of formaldehyde released from a cancer cell line treated with formaldehyde-releasing anticancer prodrugs

Bareket

Rephaeli

Berkovitch

et al. 2010

Bioelectrochemistry

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“…2,7,[8][9][10] Recently, carbon nanotubes were employed as a promising electrode material giving enhanced performances with less overpotentials and enhanced sensitivities.…”

Section: 6mentioning

confidence: 99%

“…2,6 Various redox mediators with quinone groups making two-electron and hydride transfer possible were reported as good candidates. 2,7,[8][9][10] Recently, carbon nanotubes were employed as a promising electrode material giving enhanced performances with less overpotentials and enhanced sensitivities. [11][12][13][14] The carbon nanotubes (CNTs) in the nanocomposite films show good charge transport properties resulting in less overpotentials and good stabilities.…”

Section: 6mentioning

confidence: 99%

Enhanced Electrocatalytic Activity for the NADH Oxidation with Oxidatively Treated Carbon Nanotubes Incorporated on a Redox Polymer Modified Electrode

Shin¹,

Shin²,

Kang³

2012

Bulletin of the Korean Chemical Society

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The electrochemical oxidation of dihydronicotinamide adenine dinucleotide (NADH) has drawn many attentions for use of its oxidized form (NAD + ) as an enzymatic cofactor in many dehydrogenase based biosensors and biofuel cells. 1,2At neutral pH, NADH/NAD + couple has a formal potential of −0.320 V (vs NHE), 3 but large oxidation overpotentials are generally required.2,4 In addition to this problem, direct oxidation of NADH shows unwanted side reactions or adsorption of the product. 5,6To avoid these problems, many studies using various electrocatalysts were reported. In this point of view, mediatormodified electrodes and electrochemical sensing designs were reviewed.1,2,7 The oxidation of NADH is known to follow an ECE mechanism with a rate-limiting step in the first electron transfer.2,6 Various redox mediators with quinone groups making two-electron and hydride transfer possible were reported as good candidates. 2,7,[8][9][10] Recently, carbon nanotubes were employed as a promising electrode material giving enhanced performances with less overpotentials and enhanced sensitivities.11-14 The carbon nanotubes (CNTs) in the nanocomposite films show good charge transport properties resulting in less overpotentials and good stabilities. 12,15In the present study, a redox polymer, the copolymer of polyacrylamide and poly(N-vinylimidazole) complexed with [Os(4,4'-dimethyl-2,2'-bipyridine), was employed for the electron transfer mediator for NADH oxidation. The redox polymers have been utilized for mediating electrons between the redox centers of enzymes and electrode surfaces.16,17 Some oxidase enzymes were "wired" to carbon electrodes and efficient electrocatalytic reactions such as glucose oxidation and O 2 reductions were reported. [16][17][18][19] At an electrode with a hydrogel film of the redox polymer, which is not a quinone-like mediator, catalytic electro-oxidation of NADH, but only a partial fraction, was measured. A composite film of the redox polymer and oxidatively treated single-walled carbon nanotubes (SWNTs) was applied on an edge plane graphite electrode surface. At this newly prepared electrode, an enhanced activity showing most NADH catalytically oxidized with less overpotential was achieved. As far as we know, the present redox polymer-CNT composite system, which is not a quinone type mediator, is first for the electrocatalytic NADH oxidation.Cyclic voltammograms obtained in a 2.0 mM NADH solution at bare EPG and RP/EPG electrodes for Figures 1(a) and 1(b), respectively, were shown. (For abbreviations of electrode types, consult the experimental section.) Voltammograms obtained in a pure supporting electrolyte were also shown as dashed curves. In Figure 1(a), only one oxidation wave for NADH oxidation was observed with a peak potential of 0.34 V. In Figure 1(b), in the absence of .

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Non-enzymatic oxidation of NADH by quinones

Cited by 14 publications

References 19 publications

The synthesis of new cyclic thioquinone derivatives

The synthesis of new cyclic thioquinone derivatives

Carbon nanotubes based electrochemical biosensor for detection of formaldehyde released from a cancer cell line treated with formaldehyde-releasing anticancer prodrugs

Enhanced Electrocatalytic Activity for the NADH Oxidation with Oxidatively Treated Carbon Nanotubes Incorporated on a Redox Polymer Modified Electrode

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