Non‐Enzymatic Electrochemical Detection of Glucose with a Gold Nanowire Array Electrode

Abstract

High‐performance electrodes for in vivo electrochemical detection of glucose (GO) are highly desirable. In this work, we propose a new approach to efficiently and precisely prepare a Au nanowire array electrode (ANAE) with a line width of 78 nm and a large sensor area of 60 mm×60 mm for GO detection. In this approach three techniques, i.e., vacuum sputtering‐deposition, holography photolithography, and argon ion‐beam etching, are integrated. The fabricated ANAE exhibits good performance for GO detection. A linear amperometric response to the oxidation of GO in a concentration range of 0.4–10 mM is observed. The ANAE is characterized by its high detection sensitivity, selectivity, stability and good biocompatibility. All of these make it a promising tool for GO detection and other relevant applications.

Nanoenabling electrochemical sensors for life sciences applications

“…The network film electrode biosensor fabricated with 2 nm Au NWs exhibits high sensitivity (56.0 μA cm -2 mM -1 ), low detection limit (20 μM), short response time (within 10s), excellent selectivity, and good storage stability for a nonenzymatic glucose sensor 89. Cherevko and Chung reported a gold nanowire array electrode for non-enzymatic voltammetric and amperometric glucose detection 90. The wide dynamic range and high sensitivity, selectivity and stability, as well as good biocompatibility of the Au NW electrode make it promising for the fabrication of non-enzymatic glucose sensors.…”

Non-enzymatic glucose biosensor based on hyperbranched pine-like gold nanostructure

“…There have been developed glucose sensors using different nanomaterials including platinum, gold, palladium, and metal oxides [1,[4][5][6]. Among them, due to biocompatibility, higher activity, and lower potential of glucose electrooxidation, gold is one of the most inspiring materials for the fabrication of glucose sensors [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26].…”

Development of non-enzymatic glucose electrode based on Au nanoparticles decorated single-walled carbon nanohorns

“…Then, gluconolactone was further oxidized to produce peak 2. The AuOH site is considered as the active site for glucose oxidation and the oxidation of glucose on Au depends largely on the number of AuOH sites available [28]. Usually, the OH − ions in the NaOH solution adsorb onto the surface of the gold at a certain potential to form an active site.…”