Non–diffuse large B-cell lymphoma transformation from follicular lymphoma: a single-institution study of 19 cases

Maeshima, Akiko Miyagi; Taniguchi, Hirokazu; Ida, Hanae; Hosoba, Rika; Fujino, Takahiro; Saito, Yo; Yuda, Sayako; Makita, Shinichi; Fukuhara, Suguru; Munakata, Wataru; Suzuki, Tatsuya; Maruyama, Dai; Izutsu, Koji

doi:10.1016/j.humpath.2020.06.001

Cited by 10 publications

(12 citation statements)

References 32 publications

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“…Inclusion criteria: (1) grade 1-3a FL confirmed by pathology and immunohistochemistry ( 15 ); (2) not receiving antitumor therapy before diagnosis; (3) complete medical records and follow-up information. Exclusion criteria: (1) diseases with varying effects on lymphocyte levels and albumin levels, such as chronic kidney disease; (2) mixed components or histological transformation in the pathological tissue at diagnosis ( 16 ); (3) other tumor-related diseases. This study was approved by The Ethics Committee of Scientific Research and Clinical Trial the First Affiliated Hospital of Zhengzhou University and followed the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

The prognostic nutritional index, an independent predictor of overall survival for newly diagnosed follicular lymphoma in China

Lei²,

Wen³

et al. 2022

Front. Nutr.

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ObjectiveThe prognostic nutritional index (PNI) is an important prognostic factor for survival outcomes in various hematological malignancies. The current study focused on exploring the predictive value of the PNI in newly diagnosed follicular lymphoma (FL) in China.Materials and methodsThe clinical indicators and follow-up data of 176 patients who received chemotherapy or immunotherapy combined with chemotherapy with FL in our hospital from January 2016 to March 2022 were retrospectively analyzed. Cox proportional hazard model was used for univariate and multivariate analyses. Kaplan–Meier curves were used to calculate survival rates and draw survival curves. The log-rank test was applied to compare differences between groups.ResultsThe optimal cut-off value of PNI was 44.3. All patients were divided into a high PNI group (>44.3) and a low PNI group (≤44.3). The low PNI group had a low CR rate and a high risk of death, with a tendency toward POD24, and Both OS and PFS were worse than those in the high PNI group. PNI was able to predict OS and PFS in FL patients and was the only independent predictor of OS (P = 0.014 HR 5.024; 95%CI 1.388∼18.178) in multivariate analysis. PNI could re-stratify patients into groups of high FLIPI score, high FLIPI2 score, no POD24, and rituximab combined with chemotherapy. Moreover, integrating PNI into the FLIPI and FLIPI2 models improved the area under the curve (AUC) for more accurate survival prediction and prognosis.ConclusionPNI is a significant prognostic indicator for newly diagnosed FL in China that can early identify patients with poor prognosis and guide clinical treatment decisions.

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Section: Methodsmentioning

confidence: 99%

The prognostic nutritional index, an independent predictor of overall survival for newly diagnosed follicular lymphoma in China

Lei²,

Wen³

et al. 2022

Front. Nutr.

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“…In follicular lymphoma, transformation usually results in DLBCL or high-grade B-cell lymphoma with MYC and BCL2 rearrangements ( 63 ). Transformation to cHL is rare ( 64 ).…”

Section: Potential Clinical Applicationsmentioning

confidence: 99%

Read the clonotype: Next-generation sequencing-based lymphocyte clonality analysis and perspectives for application in pathology

Groenen

Brand²,

Kroeze³

et al. 2023

Front. Oncol.

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Clonality assessment using the unique rearrangements of immunoglobulin (IG) and T-cell receptor (TR) genes in lymphocytes is a widely applied supplementary test for the diagnosis of B-cell and T-cell lymphoma. To enable a more sensitive detection and a more precise comparison of clones compared with conventional clonality analysis based on fragment analysis, the EuroClonality NGS Working Group developed and validated a next-generation sequencing (NGS)-based clonality assay for detection of the IG heavy and kappa light chain and TR gene rearrangements for formalin-fixed and paraffin-embedded tissues. We outline the features and advantages of NGS-based clonality detection and discuss potential applications for NGS-based clonality testing in pathology, including site specific lymphoproliferations, immunodeficiency and autoimmune disease and primary and relapsed lymphomas. Also, we briefly discuss the role of T-cell repertoire of reactive lymphocytic infiltrations in solid tumors and B-lymphoma.

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“… 4 , 5 More than 90% of transformed FLs (tFLs) are of diffuse large B-cell lymphoma (DLBCL) morphology, usually of the germinal center B-cell (GCB) type, but transformation to other types of lymphomas, including classic Hodgkin lymphoma, high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, B-lymphoblastic leukemia/lymphoma, plasmablastic lymphoma, and even histiocytic/dendritic cell tumors, is documented. 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

Transformation of FL into DLBCL with a PMBL gene expression signature

Loveday

Duns²,

Rimsza

et al. 2023

Blood Advances

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We investigated the clinicopathologic features of 5 follicular lymphomas (FL) that transformed to morphologic diffuse large B-cell lymphomas (DLBCL) and had a primary mediastinal large B-cell lymphoma (PMBL)-like gene expression profile (tFL-PMBLsig-pos). None of the tFL-PMBLsig-pos arose in the mediastinum, all cases tested had a germinal center B-cell phenotype, 20% were CD30+, 60% CD23+, 80% MAL+, 20% CD200+, and 0% CD273/PDL2+. Whole exome sequencing detected alterations in genes associated with both FL/DLBCL (CREBBP, KMT2C, KMT2D, ARID1A, HIST1 members, and TNFRSF14) and PMBL (JAK-STAT pathway genes, B2M, and CD58). Copy number (CN) analysis detected gains/amplification of REL and STAT6 in 60%, gains of SOCS1 in 40%, and gains of chromosome 16, including IL4R, in 40%. CN gains/amplification of BCL6 and MYC and loss of TNFRSF14 and TNFAIP3 were identified in 20%. 3/5 cases lacked a BCL2 rearrangement. Despite having some features that are less common in DLBCL (MAL and CD23 expression, JAK-STAT activation), these tFL-PMBLsig-pos cases lack the most characteristic CN alteration seen in PMBL (9p24.1 gain/amplification). This cohort expands the biologic heterogeneity of tFL, illustrating a subset with gene expression and some genetic features reminiscent of PMBL, with potential treatment implications that include the use of novel targeted therapies.

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Non–diffuse large B-cell lymphoma transformation from follicular lymphoma: a single-institution study of 19 cases

Cited by 10 publications

References 32 publications

The prognostic nutritional index, an independent predictor of overall survival for newly diagnosed follicular lymphoma in China

The prognostic nutritional index, an independent predictor of overall survival for newly diagnosed follicular lymphoma in China

Read the clonotype: Next-generation sequencing-based lymphocyte clonality analysis and perspectives for application in pathology

Transformation of FL into DLBCL with a PMBL gene expression signature

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