Non-destructive X-ray tomography of brain tissue ultrastructure
Carles Bosch,
Tomas Aidukas,
Mirko Holler
et al.
Abstract:Wiring diagrams of neural circuits are of central importance in delineating mechanisms of computation in the brain (Lichtman and Sanes, 2008; Litwin-Kumar and Turaga, 2019). To generate these diagrams, the individual parts of neurons - axons, dendrites and synapses - must be densely identified in 3-dimensional volumes of neuronal tissue. This is typically achieved by electron microscopy (Kornfeld and Denk, 2018), necessitating physical sectioning of the specimen either before or during the image acquisition pr… Show more
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