Non-destructive quantification of fragmentation within tablets after compression from scattering analysis of terahertz transmission measurements

Skelbæk-Pedersen, Anne Linnet; Anuschek, Moritz; Vilhelmsen, Thomas Kvistgaard; Rantanen, Jukka; Zeitler, J. Axel

doi:10.1016/j.ijpharm.2020.119769

Cited by 24 publications

(10 citation statements)

References 31 publications

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“…The absorption peak characteristics of different cellulose samples were investigated by the THz time-domain spectroscopy (TAS7500SP, Advantest, Japan) [28][29][30][31]. To ensure smooth surface and target thickness, using the tablet press, 10 MPa pressure was applied on all samples for tests.…”

Section: Terahertz Spectroscopy Analysismentioning

confidence: 99%

Novel Terahertz Spectroscopy Technology for Crystallinity and Crystal Structure Analysis of Cellulose

et al. 2020

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Crystallinity is an essential indicator for evaluating the quality of fiber materials. Terahertz spectroscopy technology has excellent penetrability, no harmful substances, and commendable detection capability of absorption characteristics. The terahertz spectroscopy technology has great application potential in the field of fiber material research, especially for the characterization of the crystallinity of cellulose. In this work, the absorption peak of wood cellulose, microcrystalline cellulose, wood nano cellulose, and cotton nano cellulose were probed in the terahertz band to calculate the crystallinity, and the result compared with XRD and FT-IR analysis. The vibration model of cellulose molecular motion was obtained by density functional theory. The results showed that the average length of wood cellulose (WC) single fiber was 300 μm. The microcrystalline cellulose (MCC) was bar-like, and the average length was 20 μm. The cotton cellulose nanofiber (C-CNF) was a single fibrous substance with a length of 50 μm, while the wood cellulose nanofiber (W-CNF) was with a length of 250 μm. The crystallinity of cellulose samples in THz was calculated as follows: 73% for WC, 78% for MCC, 85% for W-CNF, and 90% for C-CNF. The crystallinity values were obtained by the three methods which were different to some extent. The absorption peak of the terahertz spectra was most obvious when the samples thickness was 1 mm and mixed mass ratio of the polyethylene and cellulose was 1:1. The degree of crystallinity was proportional to the terahertz absorption coefficients of cellulose, the five-movement models of cellulose molecules corresponded to the five absorption peak positions of cellulose.

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Section: Terahertz Spectroscopy Analysismentioning

confidence: 99%

Novel Terahertz Spectroscopy Technology for Crystallinity and Crystal Structure Analysis of Cellulose

et al. 2020

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“…For tablets of the same material with the same microstructure n eff should result in the same value. However, while the work by SkelbÃ¦k-Pedersen et al did report a difference in microstructure between tablets of different MCC size fractions ( Skelbæk-Pedersen et al, 2020a , Skelbæk-Pedersen et al, 2020b , Skelbæk-Pedersen et al, 2020c ), in their study on measuring water ingress into the porous tablet matrix it was not explored specifically that THz-TDS is able to measure this difference in structure but the work focused on the liquid transport kinetics ( Skelbæk-Pedersen et al, 2020a ). Further analysis of the data show that the AB-EMA model, L l and L u , and the mAB-EMA both suggest more oblate shaped pores, based on higher L values, for the tablets prepared from the small compared to the large size fraction.…”

Section: Resultsmentioning

confidence: 99%

Terahertz time-domain spectroscopy for powder compact porosity and pore shape measurements: An error analysis of the anisotropic bruggeman model

Anuschek

Bawuah

Zeitler

2021

International Journal of Pharmaceutics: X

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Terahertz time-domain spectroscopy (THz-TDS) is a novel technique which has been applied for pore structure analysis and porosity measurements. For this, mainly the anisotropic Bruggeman (AB-EMA) model is applied to correlate the effective refractive index ( n eff ) of a tablet and the porosity as well as to evaluate the pore shape based on the depolarisation factor L . This paper investigates possible error sources of the AB-EMA for THz-TDS based tablet analysis. The effect of absorption and tablet anisotropy – changes of pore shape with porosity and density distribution – have been investigated. The results suggest that high tablet absorption has a negligible effect on the accuracy of the AB-EMA. In regards of tablet anisotropy the accuracy of the porosity determination is not impaired significantly. However, density distribution and variations in the pore shape with porosity resulted in an unreliable extraction of the tablet pore shape. As an extension of the AB-EMA a new concept was introduced to convert the model into bounds for L . This new approach was found useful to investigate tablet pore shape but also the applicability of the AB-EMA for an unknown set of data.

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“…Their size would need to be estimated by an orthogonal technical for example with terahertz transmission measurements. 48…”

Section: Discussionmentioning

confidence: 99%

Mechanistic Models for USP2 Dissolution Apparatus, Including Fluid Hydrodynamics and Sedimentation

Pépin

Goetschy

Abrahmsén-Alami

2022

Journal of Pharmaceutical Sciences

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Non-destructive quantification of fragmentation within tablets after compression from scattering analysis of terahertz transmission measurements

Cited by 24 publications

References 31 publications

Novel Terahertz Spectroscopy Technology for Crystallinity and Crystal Structure Analysis of Cellulose

Novel Terahertz Spectroscopy Technology for Crystallinity and Crystal Structure Analysis of Cellulose

Terahertz time-domain spectroscopy for powder compact porosity and pore shape measurements: An error analysis of the anisotropic bruggeman model

Mechanistic Models for USP2 Dissolution Apparatus, Including Fluid Hydrodynamics and Sedimentation

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