Non-Descemet Stripping Automated Endothelial Keratoplasty for Endothelial Dysfunction Secondary to Argon Laser Iridotomy

Intraocular pressure after Descemet’s stripping and non-Descemet’s stripping automated endothelial keratoplasty

“…DSAEK and nDSAEK procedures are described in detail by Kobayashi and Yokogawa and colleagues. 7,8,10 In brief, donor grafts for all 24 eyes were prepared with a microkeratome (ALTK Cbm, Moria, Antony, France) equipped with a 300-μm head and an 8.0-mm-diameter punch (Barron donor cornea punch, Katena Products, Denville, NJ, USA). In 14 of the 24 cases, simultaneous cataract procedures (phacoemulsifi cation and intraocular lens implantation) were performed just prior to both the DSAEK and nDSAEK surgery.…”

“…4,6 Recently, we reported a successful modifi cation of DSAEK without Descemet's membrane peeling for bullous keratopathies secondary to Argon laser iridotomy; we termed the modifi ed procedure non-Descemet's stripping automated endothelial keratoplasty (nDSAEK). 7,8 After both DSAEK and nDSAEK surgery, corneal thickness inevitably increases owing to the addition of the donor graft. Therefore, there is a possibility that intraocular pressure (IOP) measurement methods dependent on normal corneal thickness, such as Goldmann applanation tonometry (GAT), may produce less accurate readings.…”

Clinical evaluation of non-Descemet stripping automated endothelial keratoplasty (nDSAEK)

“…1) [14,15]. In those preliminary studies using a small number of patients, nDSAEK was shown to be potentially effective for endothelial dysfunction without guttae, with rapid visual recovery and minimal induced astigmatism for at least 6 months [14,15]. Here, we report our clinical outcomes of nDSAEK with a larger number of patients for a longer period of time.…”

“…All patients read and signed an informed consent document prior to enrollment. For all patients, the Descemet membrane was not removed during endothelial keratoplasty (nDSAEK) since none of them had guttae, and good visual acuity was expected without any Descemet membrane removal [14,15].…”

“…Previously, Price and co-workers [12,13] reported successful endothelial keratoplasty without Descemet stripping for non-Fuchs-type bullous keratopathy, and we called the modified procedure nonDescemet stripping automated endothelial keratoplasty (nDSAEK; Fig. 1) [14,15]. In those preliminary studies using a small number of patients, nDSAEK was shown to be potentially effective for endothelial dysfunction without guttae, with rapid visual recovery and minimal induced astigmatism for at least 6 months [14,15].…”