Non-cytotoxic nanoparticles re-educating macrophages achieving both innate and adaptive immune responses for tumor therapy

Wang, Shengmei; Liu, Xuanjun; Yang, Moon-Sik; Ouyang, Linqi; Ding, Jinsong; Wang, Shengfeng; Zhou, Wenhu

doi:10.1016/j.ajps.2022.06.001

Cited by 11 publications

(10 citation statements)

References 59 publications

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“…The coordination ratio of PA/ Fe 3+ was optimized to be 2/1 (w/w) (Additional file 1: Table S1), and the resulting PA/Fe 3+ MOF displayed a dynamic size ~ 146 nm with PDI of 0.155. We then used such MOF nanoparticles for MTO loading based on our previous reports (Guo et al 2023;Wang et al 2022). Interestingly, the feeding MTO concentration has little effect on drug loading efficiency, but affected particle size significantly (Additional file 1: Table S2), and the smallest size of MTO@PA/Fe 3+ MOF was obtained at 0.125 mg/ mL (135 nm, PDI = 0.002) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Targeting nano-regulator based on metal–organic frameworks for enhanced immunotherapy of bone metastatic prostate cancer

et al. 2023

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Bone metastasis is the main cause of death in patients with prostate cancer (PCa), but there lacks effective treatment method. Immunotherapy shows new hopes for bone metastatic PCa patients, while the efficacy is still unsatisfactory and limited by the unique immunosuppressive microenvironment in metastatic bone site. Here, we developed a bone-targeted nano-delivery system as a nano-regulator to enhance the immunotherapy of bone metastatic PCa. The nanosystem was assembled via coordination between phytic acid (PA) and Fe3+ to form nano-sized metal–organic framework (MOF), through which mitoxantrone (MTO) was encapsulated. At cellular level, the nanosystem showed selective cytotoxicity towards RM-1 PCa cells over immune cells, and could induce tumor cells immunogenic cell death (ICD) to improve the immunogenicity of the tumor. Moreover, the nanosystem was able to induce ubiquitination of TGFβ receptor (TβR) on immune cells to promote its degradation, thus serving as a nano-regulator to block the functions of TGF-β, an abundant cytokine that has a systematically immunosuppressive effect in the tumor microenvironment. Upon intravenous injection, the nanoparticle showed pro-longed blood circulation and targeting accumulation into bone metastatic site, and imposed robust anti-tumor effect in combination with αCTLA-4. In addition, bone destruction was significantly alleviated after treatment to reduce the skeletal-related events. Overall, this work provides a biocompatible nanomedicine to restore immune sensitivity of bone metastatic tumor for enhanced immunotherapy by blocking TGF-β signaling pathway.

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Section: Resultsmentioning

confidence: 99%

Targeting nano-regulator based on metal–organic frameworks for enhanced immunotherapy of bone metastatic prostate cancer

et al. 2023

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“…Wang et al [ 57 ] designed a nanostructure loaded with IPI549, a phosphoinositide‐3‐kinase‐gamma inhibitor, and CpG, a Toll‐like receptor 9 agonist. An MOF shell layer was used to coat CpG, leading to very high drug loadings of about 44%.…”

Section: Drug‐loaded Mofs For Cancer Treatmentmentioning

confidence: 99%

“…[46] Enzyme-responsive substances such as hyaluronidase (HAase), [54] pectinase, [55] and cathepsin B (CaB) [56] have been used for the design of enzyme-responsive MOFs for drug delivery applications. [45] Wang et al [57] designed a nanostructure loaded with IPI549, a phosphoinositide-3-kinase-gamma inhibitor, and CpG, a Toll-like receptor 9 agonist. An MOF shell layer was used to coat CpG, leading to very high drug loadings of about 44%.…”

Section: Enzyme-responsivementioning

confidence: 99%

“…The MOF comprised a 4,4 0 -(diazene-1,2-diyl)bis (3,5-difluorobenzoic acid) ligand (UiO-AZB-F) that responded to green light. 4,4 0 -azobenzenedicarboxylic 57.9 (wt%) [38] UiO-66, UiO-66-NH 2 SiO 2 FA-pluronic F127 DOX -5.6 (wt%) [43] Ni-Ta core-shell MOF FA-CS DOX-CUR 13% increment (pH 5) - [41] MOF-808 PAAMAM Carboplatin/ Floxuridine -- [39] MOF IPI549, CpG Tolllike receptor --4 4 [57] (IRMOF3)-Zn 2+ FA DSF -- [42] Zn-H 2 BDP-X (X = H, NO acid (AZB) possesses a photoswitchable azobenzene ligand. After exposure to light, this compound experienced photoisomerization, which led to the decomposition of the network and the release of the encapsulated cargo.…”

Section: Enzyme-responsivementioning

confidence: 99%

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Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Pourmadadi

Ostovar

Eshaghi

et al. 2023

Applied Organom Chemis

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Recently, metal-organic frameworks (MOFs) have received a lot of interest for application in many fields ranging from catalysis, energy storage, and gas sensing to chemosensory and biomedicine owed to their flexible composition, tunable porosity, and easy functionalization ability. In particular, nanoscale MOFs have been broadly investigated as carriers for the delivery of therapeutics to cancerous organs owed to their high encapsulating capacity and controlled cargo release, versatility, biodegradability, and good biocompatibility.Several methods such as solvothermal, mechanochemical, electrochemical, microwave, and ultrasound have been utilized to fabricate MOFs via custommade synthesis. Many efforts have been made to functionalize MOFs through "post-synthetic modification," by adjusting the nature, size, and charge of the linkers or tuning its main components. Herein, a comprehensive literature review on recent papers dealing with drug-loaded MOFs for the detection and treatment of cancer as well as bacterial, fungal, and viral infections is presented. Different types of MOFs applied as carriers in drug delivery systems and biosensing platforms are described. Furthermore, perspectives and challenges for future research in the field, particularly for cancer therapy, are discussed. Thus, very limited literature is available on in vitro and in vivo toxicity of nanoscale MOFs. Besides, their biological stability and long-term safety are crucial factors that should be further investigated. Based on the reviewed papers, zeolite imidazolate framework (ZIF) and Materials of Institute Lavoisier (MIL) families have been the main focus for drug delivery and diagnosis applications, respectively, while many types of MOFs have exhibited antibacterial and antifungal properties regardless of their cargo.

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“…[38][39][40][41][42] Nanoparticles sizes used in this application have average around 25 to 82 nm that in dark cytotoxicity assays (MTT assay, olive moment, neutral comet assay, lactate dehydrogenase assay) prove to be biocompatible by showing cell viabilities after 48 hours of incubation of 80% in cells of the immune system, cells of the HeLa type, A375, HGF, HepG2, and fibroblasts. [43][44][45][46][47][48][49] This work reports the synthesis of the new chalcones (2E…”

Section: Introductionmentioning

confidence: 99%

Fabrication of photoluminescent nanoparticles from carbazole-derived chalcones: a study of optical properties, cell biomarking, and metabolism

Estrada-Flores¹,

Garcías-Morales²,

Pérez-Berumen³

et al. 2023

Mater. Adv.

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Non-cytotoxic nanoparticles re-educating macrophages achieving both innate and adaptive immune responses for tumor therapy

Cited by 11 publications

References 59 publications

Targeting nano-regulator based on metal–organic frameworks for enhanced immunotherapy of bone metastatic prostate cancer

Targeting nano-regulator based on metal–organic frameworks for enhanced immunotherapy of bone metastatic prostate cancer

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Fabrication of photoluminescent nanoparticles from carbazole-derived chalcones: a study of optical properties, cell biomarking, and metabolism

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