Non-cytotoxic and non-genotoxic wear debris of strontium oxide doped (Zirconia Toughened Alumina) (SrO-ZTA) implant for hip prosthesis

Nayak, Nibedita; Basha, Shaik Akbar; Tripathi, Surya Kant; Biswal, Bijesh K.; Mishra, Monalisa; Sarkar, Debasish

doi:10.1016/j.matchemphys.2021.125187

Cited by 9 publications

(8 citation statements)

References 47 publications

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“…However, the percentage of manganese and iron increased according to the increasing concentration of MnFe 2 O 4 @poly( t BGE-alt-PA) treatment. This finding supports that no toxicity is induced by the nanocomposite and confirms the deposition of the hybrid nanocomposite in the gut …”

Section: Resultssupporting

confidence: 85%

“…However, as the MnFe2O4@poly( t BGE-alt-PA) concentration was increased, the amount of manganese and iron also increased in the gut. These results further support that the nanocomposite does not cause any toxicity, and they verify the deposit of the hybrid nanocomposite in the gut . Oxidative stress is generated by the increased production of ROS carried by silver, gold, and titanium nanoparticles.…”

Section: Discussionsupporting

confidence: 77%

“…These results further support that the nanocomposite does not cause any toxicity, and they verify the deposit of the hybrid nanocomposite in the gut. 54 Oxidative stress is generated by the increased production of ROS carried by silver, gold, and titanium nanoparticles. One well-established technique for measuring ROS concentration is the NBT test.…”

Section: Discussionmentioning

confidence: 99%

“…This finding supports that no toxicity is induced by the nanocomposite and confirms the deposition of the hybrid nanocomposite in the gut. 54 3.12. Phenotype Observation.…”

Section: Crawling Assaymentioning

confidence: 99%

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In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

Kumar

Bauri

Sahu

et al. 2023

ACS Appl. Bio Mater.

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Nanocomposites have significantly contributed to biomedical science due to less aggregation behavior and enhanced physicochemical properties. This study synthesized a MnFe2O4@poly(tBGE-alt-PA) nanocomposite for the first time and physicochemically characterized it. The obtained hybrid nanomaterial was tested in vivo for its toxicological properties before use in drug delivery, tissue engineering fields, and environmental applications. The composite was biocompatible with mouse fibroblast cells and hemocompatible with 2% RBC suspension. This nanocomposite was tested on Drosophila melanogaster due to its small size, well-sequenced genome, and low cost of testing. The larvae’s crawling speed and direction were measured after feeding. No abnormal path and altered crawling pattern indicated the nonappearance of abnormal neurological disorder in the larva. The gut organ toxicity was further analyzed using DAPI and DCFH-DA dye to examine the structural anomalies. No apoptosis and necrosis were observed in the gut of the fruit fly. Next, adult flies were examined for phenotypic anomalies after their pupal phases emerged. No defects in the phenotypes, including the eye, wings, abdomen, and bristles, were found in our study. Based on these observations, the MnFe2O4@poly(tBGE-alt-PA) composite may be used for various biomedical and environmental applications.

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Section: Resultssupporting

confidence: 85%

Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

“…This finding supports that no toxicity is induced by the nanocomposite and confirms the deposition of the hybrid nanocomposite in the gut. 54 3.12. Phenotype Observation.…”

Section: Crawling Assaymentioning

confidence: 99%

See 2 more Smart Citations

In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

Kumar

Bauri

Sahu

et al. 2023

ACS Appl. Bio Mater.

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“…The gut of third instar larvae was stained using 4′,6-diamidino-2-phenylindole (DAPI) (D9542, Sigma-Aldrich, Germany) and dichloro-dihydro-fluorescein diacetate (DCFH-DA) (D6883, Sigma-Aldrich, Germany) dyes to study the production of reactive oxygen species (ROS), which triggers the cell death. The larvae from each treated group along with the control group were collected and rinsed with 1× phosphate-buffered saline (PBS) to eliminate the food residue. , The larvae’s gut was dissected on a glass slide using fine forceps under a stereomicroscope (ACCU-SCOPE Inc., Commack, New York). The dissected guts were transferred to a 1.5 mL tube containing 4% PFA (paraformaldehyde) and further kept at 4 °C overnight.…”

Section: Methodsmentioning

confidence: 99%

In Vivo Toxicological Analysis of the ZnFe₂O₄@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly

Chauhan,

Naik,

Kumar

et al. 2024

ACS Omega

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Recently, the use of hybrid nanomaterials (NMs)/nanocomposites has widely increased for the health, energy, and environment sectors due to their improved physicochemical properties and reduced aggregation behavior. However, prior to their use in such sectors, it is mandatory to study their toxicological behavior in detail. In the present study, a ZnFe 2 O 4 @poly(tBGE-alt-PA) nanocomposite is tested to study its toxicological effects on a fruit fly model. This nanocomposite was synthesized earlier by our group and physicochemically characterized using different techniques. In this study, various neurological, developmental, genotoxic, and morphological tests were carried out to investigate the toxic effects of nanocomposite on Drosophila melanogaster. As a result, an abnormal crawling speed of third instar larvae and a change in the climbing behavior of treated flies were observed, suggesting a neurological disorder in the fruit flies. DAPI and DCFH-DA dyes analyzed the abnormalities in the larva's gut of fruit flies. Furthermore, the deformities were also seen in the wings and eyes of the treated flies. These obtained results suggested that the ZnFe 2 O 4 @poly(tBGE-alt-PA) nanocomposite is toxic to fruit flies. Moreover, this is essential to analyze the toxicity of this hybrid NM again in a rodent model in the future.

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Exposure of piperlongumine attenuates stemness and epithelial to mesenchymal transition phenotype with more potent anti-metastatic activity in SOX9 deficient human lung cancer cells

Tripathi,

Sahoo,

Biswal

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Non-cytotoxic and non-genotoxic wear debris of strontium oxide doped (Zirconia Toughened Alumina) (SrO-ZTA) implant for hip prosthesis

Cited by 9 publications

References 47 publications

In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

In Vivo Toxicological Analysis of the ZnFe₂O₄@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly

Exposure of piperlongumine attenuates stemness and epithelial to mesenchymal transition phenotype with more potent anti-metastatic activity in SOX9 deficient human lung cancer cells

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Non-cytotoxic and non-genotoxic wear debris of strontium oxide doped (Zirconia Toughened Alumina) (SrO-ZTA) implant for hip prosthesis

Cited by 9 publications

References 47 publications

In Vivo Toxicological Analysis of MnFe2O4@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

In Vivo Toxicological Analysis of MnFe2O4@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

In Vivo Toxicological Analysis of the ZnFe2O4@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly

Exposure of piperlongumine attenuates stemness and epithelial to mesenchymal transition phenotype with more potent anti-metastatic activity in SOX9 deficient human lung cancer cells

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Product

Resources

About

In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

In Vivo Toxicological Analysis of the ZnFe₂O₄@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly