Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity

Pang, Xiaoyan; Tang, Chongzhuang; Guo, Runcong; Chen, Xiaoyan

doi:10.1016/j.pharmthera.2021.108020

Cited by 13 publications

(5 citation statements)

References 331 publications

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“…In the present study, the mRNA expression of CYP450 subtypes CYP1a1 were lower level in adult stage compared with juvenile and young stage. Non-cytochrome P450 enzymes includes DHDH, CBR1, GST, MAO, AOX, UGT, and so on (Pang et al, 2022). Dihydrodiol dehydrogenase (DHDH) is involved in the metabolism of polycyclic aromatic hydrocarbons in the liver (Carbone et al, 2008), but there is no report on the development change of DHDH in teleost fishes.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Transcriptomic Profiling During Liver Development in Schizothorax Prenanti

Zhu

et al. 2022

Front. Physiol.

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Liver is an important organ for glucose and lipid metabolism, immunity, and detoxification in fish. However, the gene regulatory network of postnatal liver development still remains unknown in teleost fish. In this study, we performed transcriptome analysis on the liver of S. prenanti at three stages. A total of 1692 differentially expressed genes (DGEs) were identified across three liver developmental stages. The oil red O staining and PAS staining revealed that the lipid content of liver was increased and the glycogen content of liver was decreased during liver development. The fatty acids biosynthesis related genes were upregulated in adult and young stages compared with juvenile stage, while lipid degradation related genes were downregulated. The genes related to glycolysis, gluconeogenesis and glycogenolysis were upregulated in juvenile or young stages compared with adult stage. Further pathway analysis indicated that the CYP450 pathway, cell cycle and amino acid metabolic pathway were induced in the process of liver maturation. Our study presents the gene expression pattern in different liver development stages of S. prenanti and may guide future studies on metabolism of S. prenanti liver.

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Section: Discussionmentioning

confidence: 99%

Dynamic Transcriptomic Profiling During Liver Development in Schizothorax Prenanti

Zhu

et al. 2022

Front. Physiol.

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“…These reactions can either enhance or reduce the biological activity of herbal compounds. Phase II enzymes, like Glucuronosyltransferases, Sulfotransferases, and Glutathione S-Transferases, facilitate conjugation reactions, making herbal compounds more water-soluble for easier excretion [17]. The interplay between Phase I and Phase II enzymes influences the fate of herbal compounds, affecting their pharmacokinetics, efficacy, and potential interactions with other drugs.…”

Section: Enzymes Involved In the Metabolism Of Herbal Compoundsmentioning

confidence: 99%

Introductory Chapter: Pharmacokinetics and Drug Metabolism with Special Reference to Herbal Formulations

Sharma,

Siwan,

Rudrapal

2024

Drug Metabolism and Pharmacokinetics

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Plant-based treatments are crucial in achieving Sustainable Development Goal 3 (SDG 3) to ensure healthy lives and promote well-being. Integrating effective and safe herbal medical systems with traditional pharmaceutical systems can significantly enhance essential healthcare services. A survey conducted in Germany revealed that various age groups opt for herbal remedies due to dissatisfaction with allopathic treatments, the synergistic effects of medicinal plants, historical usage, and unique knowledge [1]. In the face of emerging diseases like SARS-COV-2 and mycosis, interest in phytotherapy has been rekindled to strengthen the healthcare system and combat the ongoing epidemic. Immunity-boosting plants, herbal remedies, and AYUSH compositions are being considered as preventive measures. Specific botanical formulations include the aqueous solution of Guduchi and pippali, AYUSH 64, and Guduchi aq. extracts have shown promise for mild to moderate and asymptomatic COVID-19 patients [2]. Ashwagandha and Guduchi extracts are also recommended for preventive use against COVID-19, with Withaferin A potentially acting as a therapeutic agent to inhibit viral spread. However, further research is needed to determine the long-term safety and optimal dosage [3]. Currently, herbal medicines straddle the line between conventional drugs and food. This chapter elucidates their historical significance, integration into modern healthcare, and metabolic and pharmacokinetic profiles within the human body. Importance of understanding herbal formulations' metabolism and pharmacokineticsResearchers are increasingly curious about the impact of herbal formulations on metabolism and pharmacokinetics. Pharmacokinetics (PK), a newly developed approach, is instrumental in studying drug absorption, distribution, metabolism, and excretion in vivo. When combined with other techniques, PK helps determine the active components of medicinal plants [4][5][6]. Pharmacokinetic measures like biological half-life, clearance, and AUC reveal dynamic processes of these components in vivo. Contrasting pharmacokinetic parameters aids in understanding their characteristics [7,8]. This has three benefits: precise explanation of herbal formulation effects

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“…Due to genetic polymorphism and susceptibility to induction and inhibition, P450 enzymes can cause individual medication differences and drug–drug interactions 2 , 3 , 4 . In contrast, drug interactions and individual medication differences caused by non-P450 oxidases are less frequently reported 5 , 6 . In recent years, more compounds that can potentially be metabolized by non-CYP450 enzymes have been designed and synthesized, and the role of the non-CYP450 metabolic enzymes in drug discovery has also become increasingly important 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application

Xiong,

Cui,

et al. 2024

Acta Pharmaceutica Sinica B

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Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity

Cited by 13 publications

References 331 publications

Dynamic Transcriptomic Profiling During Liver Development in Schizothorax Prenanti

Dynamic Transcriptomic Profiling During Liver Development in Schizothorax Prenanti

Introductory Chapter: Pharmacokinetics and Drug Metabolism with Special Reference to Herbal Formulations

Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application

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