Non-cystic fibrosis bronchiectasis: The long road to multidrug resistant bacteria

Abstract

model explains the evolution of this disease, in which an initial insult in the bronchi, often on a background of impaired mucociliary clearance or bactericidal activity, results in persistence of microbes in the sinobronchial tree, and microbial colonization. Microbial overgrowth then causes infection and chronic inflammation, resulting in tissue damage, and impaired mucociliary motility. This then leads to more infection with a cycle of progressive inflammation causing lung damage. [1][2][3] Subsequent antimicrobial treatments can favor the development of resistance and the appearance of multidrug-resistant (MDR) bacteria.