Non-cystic fibrosis bronchiectasis

Vitamin-D deficiency is associated with chronic bacterial colonisation and disease severity in bronchiectasis

“…This suggests that while vitamin-D may regulate LL-37 production in vitro, this is of little consequence in vivo, at least in the context of the bronchiectasis lung. Since bronchiectasis is a neutrophil driven disorder,1 we hypothesised that patients with vitamin-D deficiency may have a failure of neutrophil phagocytosis and killing of micro-organisms. We observed, however, no difference in neutrophil phagocytosis of E coli or P aeruginosa between vitamin-D deficient patients, vitamin-D sufficient patients or controls subjects.…”

“…Bronchiectasis is a chronic, debilitating, lung disease characterised by a vicious cycle of airway inflammation and bacterial colonisation 1. There are no effective long term treatments apart from antibiotics and chest clearance techniques 2.…”

Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century

“…When dealing with NCFB, other tests may indicate the underlying aetiology (table 2), including a detailed patient history, biochemical evaluation of venous blood sample, radiology, pulmonary function tests, sputum investigations and ciliary function tests 42 59…”

Risk factors for multidrug-resistant pathogens in bronchiectasis exacerbations

“…Pathogens involved depend on several aspects: lung function, advanced phase of the disease and patient comorbidities. [1,2,12] However, little is known regarding frequency and factors associated with isolation MDR at exacerbations [13].…”

“…Non-cystic fibrosis bronchiectasis (BE) is a chronic structural lung condition that facilitates chronic colonization by microorganisms and courses with frequent exacerbations and recurrent infections. [1,2] This means that patients receive numerous courses with broad-spectrum antibiotics, making them more likely to acquire MDR pathogens.…”