Non-Crh Glutamatergic Neurons in Barrington’s Nucleus Control Micturition via Glutamatergic Afferents from the Midbrain and Hypothalamus

Verstegen, Anne M.J.; Klymko, Nataliya; Zhu, Lin; Mathai, John; Kobayashi, Reina; Venner, Anne; Ross, Rachel; VanderHorst, Veronique; Arrigoni, Elda; Geerling, Joel C.; Zeidel, Mark L.

doi:10.1016/j.cub.2019.07.009

Cited by 48 publications

(61 citation statements)

References 66 publications

(96 reference statements)

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“…In rats and mice, Bar CRH neurons make up roughly half of all Bar neurons that project axons to the sacral spinal cord ( Valentino et al, 1995 ; Verstegen et al, 2017 ). Optogenetic and chemogenetic experiments shows that Bar CRH neurons promote bladder contraction ( Hou et al, 2016 ; Keller et al, 2018 ; Verstegen et al, 2019 ). Other recent studies verify that optogenetic stimulation of Bar CRH neurons drives bladder contraction, but typically does not result in urinary excretion ( Ito et al, 2020 ; Verstegen et al, 2019 ).…”

Section: Barrington’s Nucleus Synchronizes Bladder Contraction and Spmentioning

confidence: 99%

The Brain and the Bladder: Forebrain Control of Urinary (In)Continence

Tish

Geerling

2020

Front. Physiol.

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Neural circuits extending from the cerebral cortex to the bladder maintain urinary continence and allow voiding when it is socially appropriate. Injuries to certain brain regions produce a specific disruption known as urge incontinence. This neurologic symptom is distinguished by bladder spasticity, with sudden urges to void and frequent inability to maintain continence. The precise localization of neural circuit disruptions responsible for urge incontinence remains poorly defined, partly because the brain regions, cell types, and circuit connections that normally maintain continence are unknown. Here, we review what is known about the micturition reflex circuit and about forebrain control of continence from experimental animal studies and human lesion data. Based on this information, we hypothesize that urge incontinence results from damage to a descending pathway that normally maintains urinary continence. This pathway begins with excitatory neurons in the prefrontal cortex and relays subcortically, through inhibitory neurons that may help suppress reflex micturition during sleep and until it is safe and socially appropriate to void. Identifying the specific cell types and circuit connections that constitute the continence-promoting pathway, from the forebrain to the brainstem, will help us better understand why some brain lesions and neurodegenerative diseases disrupt continence. This information is needed to pave the way toward better treatments for neurologic patients suffering from urge incontinence.

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Section: Barrington’s Nucleus Synchronizes Bladder Contraction and Spmentioning

confidence: 99%

The Brain and the Bladder: Forebrain Control of Urinary (In)Continence

Tish

Geerling

2020

Front. Physiol.

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“…The traditional answer has been mum. Mothers modify the incubation conditions of their offspring in a variety of ways, including via maternal nest site choice at oviposition or via sophisticated thermoregulatory behaviour prior to oviposition (e.g., [3,4]).…”

Section: Dispatchesmentioning

confidence: 99%

“…Today it is widely accepted that the pons contains a neural circuit that regulates lower urinary tract function, but how does it accomplish this? In a study reported in a recent issue of Current Biology, Verstegen et al [3]. have skillfully used the latest tools of modern neurobiology to answer some very basic questions about the functional role of Barrington's nucleus; their findings contribute to a better understanding of the mechanism(s) of central neural control over lower urinary tract function.…”

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confidence: 99%

“…Verstegen et al [3] have demonstrated that two distinct neural populations within Barrington's nucleus, defined as those which express only Vglut2 and those which express Vglut2 and CRF, impact on voiding function in distinct ways. Taking advantage of the CRF-cre mouse and Vglut2-cre lines, this team was able to label these two different cell populations with Channel2 Rhodopsin, making it possible to selectively stimulate these distinct cells by the application of light delivered by a fiberoptic probe placed under stereotactic control.…”

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confidence: 99%

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Neuroscience: A New Golden Age for Neurourology

Zderic

2019

Current Biology

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“…The PMC, including both the Crh-expressing and sphincter-controlling neurons, receives inputs from distributed circuits across the brain which presumably carry proand anti-micturition information that is processed in the PMC (Hou et al, 2016;Verstegen et al, 2019;Yao et al, 2018). Thus, PMC serves as a suitable starting point to retrogradely map the neural circuitry by which information is integrated to trigger a specific motor action.…”

Section: Introductionmentioning

confidence: 99%

Social isolation uncovers a brain-wide circuit underlying context-dependent territory-covering micturition behavior

Hyun

Taranda

Radeljic

et al. 2019

Preprint

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The controlled and volitional release of urine, or micturition, serves a fundamental physiological function and, in many species, is critical for social communication. In mice, the decision to release urine is modulated by external and internal factors such as environmental stimuli and social history and is transmitted to the spinal cord via the pontine micturition center (PMC). The neural pathways by which social experience and sensory stimuli interact to control PMC activity and regulate micturition are unclear. Here we establish a behavioral paradigm in which mice, depending on their strain, social experience, and immediate sensory context, display either high or low territory-covering micturition (TCM). We demonstrate that social context is represented by coordinated global activity changes in the urination network upstream of the PMC, whereas sensory context is represented by the activation of discrete nodes in the network. Furthermore, we show that the lateral hypothalamic area (LHA), which is directly upstream of PMC, is a key node that can switch micturition behavior between high and low TCM modes. SF 366.5 384.349234 798 196.872209 0.21687968 0.80839929 AAA 910.25 185.465855 587.75 179.046316 0.00360848 0.05846712 ARH 89.75 12.3119183 97 53.4290807 0.77934917 1

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Non-Crh Glutamatergic Neurons in Barrington’s Nucleus Control Micturition via Glutamatergic Afferents from the Midbrain and Hypothalamus

Cited by 48 publications

References 66 publications

The Brain and the Bladder: Forebrain Control of Urinary (In)Continence

The Brain and the Bladder: Forebrain Control of Urinary (In)Continence

Neuroscience: A New Golden Age for Neurourology

Social isolation uncovers a brain-wide circuit underlying context-dependent territory-covering micturition behavior

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