Non-covalent inclusion of ferulic acid with α-cyclodextrin improves photo-stability and delivery: NMR and modeling studies

Anselmi, Cecilia; Centini, Marisanna; Maggiore, M.; Gaggelli, Nicola; Andreassi, Marco; Buonocore, Anna; Beretta, Giangiacomo; Facino, Roberto Maffei

doi:10.1016/j.jpba.2007.11.037

Cited by 66 publications

(51 citation statements)

References 25 publications

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“…The latter finds greater use in commercial sunscreens, on account of its superior photostability. 186 Both can be viewed as substituted phenols and, as such, both could be prone to decay via ps* state-mediated O-H bond fission following UV excitation. CA has two OH groups, only one of which can be 'protected' by an intramolecular H-bond, whereas the O-CH 3 bond is the pendant bond in the lowest energy conformer of FA.…”

Section: Molecular Constituents In Commercial Sunscreensmentioning

confidence: 99%

Photoprotection: extending lessons learned from studying natural sunscreens to the design of artificial sunscreen constituents

et al. 2017

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Evolution has ensured that plants and animals have developed effective protection mechanisms against the potentially harmful effects of incident ultraviolet radiation (UVR). Tanning is one such mechanism in humans, but tanning only occurs post-exposure to UVR. Hence, there is ever growing use of commercial sunscreens to pre-empt overexposure to UVR. Key requirements for any chemical filter molecule used in such a photoprotective capacity include a large absorption cross-section in the UV-A and UV-B spectral regions and the availability of one or more mechanisms whereby the absorbed photon energy can be dissipated without loss of the molecular integrity of the chemical filter. Here we summarise recent experimental (mostly ultrafast pump-probe spectroscopy studies) and computational progress towards unravelling various excited state decay mechanisms that afford the necessary photostability in chemical filters found in nature and those used in commercial sunscreens. We also outline ways in which a better understanding of the photophysics and photochemistry of sunscreen molecules selected by nature could aid the design of new and improved commercial sunscreen formulations.

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Section: Molecular Constituents In Commercial Sunscreensmentioning

confidence: 99%

Photoprotection: extending lessons learned from studying natural sunscreens to the design of artificial sunscreen constituents

et al. 2017

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“…Cyclodextrin has shown the potential to form stable inclusion complex with a variety of lipophilic molecules through non-covalent interactions (Anselmi et al, 2008). This is one of reasons that CD is widely applied in medicine and cosmetics.…”

Section: Storage Stabilitymentioning

confidence: 99%

Identification of cyclodextrin inclusion complex of chlorogenic acid and its antimicrobial activity

et al. 2010

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“…On this basis, it has been proposed to potentiate the photoprotective activity of FA by increasing the deliver of the polyphenol contained in commercially available sunscreens. At least two types of new drugdelivery-systems (DDS) containing FA, such as solidlipid nanoparticles and cyclodextrins, have been developed and the amount of polyphenol absorbed by the skin increased significantly and, more importantly, the formation of FA degradation products have been avoided (Anselmi et al 2008;Souto et al 2005). As a matter of fact, the preparation of novel FA-DDS may be very useful also to increase the bioavailability of the polyphenol if administered per os.…”

Section: Fa and Skinmentioning

confidence: 99%

Ferulic acid and its therapeutic potential as a hormetin for age-related diseases

2008

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Ferulic acid (FA) is a polyphenol very abundant in vegetables and maize bran. Several lines of evidence have shown that FA acts as a potent antioxidant in vitro, due to its ability to scavenge free radicals and induce a robust cell stress response through the up-regulation of cytoprotective enzymes such as heme oxygenase-1, heat shock protein 70, extracellular signal-regulated kinase 1/2 and Akt. Furthermore, FA inhibited the expression and/or activity of cytotoxic enzymes including inducible nitric oxide synthase, caspases and cyclooxygenase-2. On this basis, FA has been proposed for the treatment of several age-related diseases such as neurodegenerative disorders, cardiovascular diseases, diabetes and cancer. However, although the great abundance of in vitro data, the real efficacy of FA in humans has not been demonstrated so far. New efforts and resources should be transferred to clinical research for the complete evaluation of the therapeutic potential of FA in chronic diseases.

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Non-covalent inclusion of ferulic acid with α-cyclodextrin improves photo-stability and delivery: NMR and modeling studies

Cited by 66 publications

References 25 publications

Photoprotection: extending lessons learned from studying natural sunscreens to the design of artificial sunscreen constituents

Photoprotection: extending lessons learned from studying natural sunscreens to the design of artificial sunscreen constituents

Identification of cyclodextrin inclusion complex of chlorogenic acid and its antimicrobial activity

Ferulic acid and its therapeutic potential as a hormetin for age-related diseases

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