N anotechnology is technology that is based on the exploitation of properties of nanomaterials, which are materials with at least one dimension less than 100 nm. The ability to reproducibly control matter at this extreme scale is important to both the development and success of nanotechnology and has been enabled by advances in instrumentation, synthesis, fabrication, and characterization in the past few decades (Siegel et al. 1999, 336). These advances include the ability to image and manipulate individual atoms, the ability to synthesize monodisperse nanoparticles, the discovery and manufacture of carbon nanotubes, and nanoscale lithography. A nanotechnology-enhanced component may appear to be little more than a pile of powder (Nohynek 2007), a bottle of solution (Daniel 2004), or an invisible surface coating (Ulman 1996). Despite concerns that the small length scales complicate the management of functional interfaces within a macroscopic system, the majority of nanomaterials that are in use today operate through aggregate behavior and therefore have little functional difference from a bulk material.Although the discovery and subsequent exploitation of nanomaterials have led to some of the greatest leaps in physical properties over the last twenty years, the technology still has its limitations. The systems engineer must be mindful of the underlying physics in order to properly apply these technologies to meet customer needs and objectives. The main advantages conferred by the reduced length scale include (1) quantum effects, (2) non-averaged properties, (3) large surface-to-volume ratio, (4) short diffusion lengths, and (5) thermal activation.The large surface-to-volume ratio arises from the fact that surface area scales with the square of size, whereas the volume scales with the third power. Consequently, 60% of the atoms in a 2.5 nm nanoparticle are at the surface (Wengemayr 2001). The large surface area has implications for any process that occurs at a surface: catalysis, conduction, chromatography, detection, friction, or adhesion. In most of these processes, the properties improve with increasing surface area without limit. Nanotechnology is therefore especially important for power-and-energy systems because batteries, supercapacitors, photovoltaics, and fuel cells all perform their function across a material-to-material interface. Short diffusion lengths also benefit the performance of these power-andenergy systems. By decreasing the distance over which an atom, ion, or electron has to travel, the amount of time required decreases accordingly. For diffusive processes, the rate scales with the inverse square of distance, greatly improving power generation.Examples of such behavior can be seen in living systems. All organisms exploit nanotechnology in the sense that cell membranes, proteins, and DNA are all nanoscale objects. So everything from chemical detection by ants, the logic function of the human brain, and the mechanical properties of abalone shells depend in one form or another on nanoscale pheno...