Non-covalent binding of luminescent transition metal polypyridine complexes to avidin, indole-binding proteins and estrogen receptors

Lo, Kenneth Kam‐Wing; Tsang, Keith Hing-Kit; Sze, Ka-Shing; Chung, Chi-Keung; LEE, T; ZHANG, K; Hui, Wai-Ki; LI, C; Lau, Jonathan Chun-Wai; Ng, Dominic Chun-Ming

doi:10.1016/j.ccr.2006.12.005

Cited by 132 publications

(70 citation statements)

References 120 publications

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“…Additional NMR spectra (where solubility allowed) including 1 The optimized ground state S 0 geometries were calculated at the B3LYP/LANL2DZ:3-21G* level with the LANL2DZ pseudopotential for the iridium atoms and the 3-21G* basis set for other atoms. These data are, therefore, directly comparable to previous computational studies on Ir(ppy) 3 and other diiridium complexes. 16,39 As a general trend in the optimized geometries, the central bridge CNNC dihedral angle is calculated to be planar (180º) for the meso (a) isomers, whereas it is twisted for the rac (b) isomers and displays greater variation between complexes (144-156º).…”

Section: Synthesissupporting

confidence: 79%

“…Luminescent Ir(III) complexes have been widely employed in a diverse range of applications, 1 such as photocatalysis, 2 biological labelling [2][3][4] and sensing. 5 Moreover, they have received particular attention as phosphorescent emitters in organic light-emitting devices (OLEDs) and light-emitting electrochemical cells (LECs), 6,7 where heavy atom induced spin-orbit coupling theoretically enables the harvesting of all electro-generated excitons.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Diastereomer Separation, and Optoelectronic and Structural Properties of Dinuclear Cyclometalated Iridium(III) Complexes with Bridging Diarylhydrazide Ligands

et al. 2017

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(2017) 'Synthesis, diastereomer separation, and optoelectronic and structural properties of dinuclear cyclometalated iridium(III) complexes with bridging diarylhydrazide ligands. ', Organometallics., 36 (5). pp. 981-993.Further information on publisher's website:https://doi.org/10.1021/acs.organomet.6b00887Publisher's copyright statement:This document is the Accepted Manuscript version of a Published Work that appeared in nal form in Organometallics, copyright c 2017 American Chemical Society after peer review and technical editing by the publisher. To access the nal edited and published work see https://doi.org/10.1021/acs.organomet.6b00887. Additional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. ABSTRACT: A series of diiridium complexes 13-16 bridged by diarylhydrazine ligands and cyclometalated by phenylpyridine or phenylpyrazole ligands was synthesized. In all cases the ɅΔ meso and ɅɅ/ΔΔ rac diastereomers were separated and characterized by single-crystal X-ray diffraction, revealing intramolecular - stacking between arenes of the bridging and cyclometalating ligands. Density functional theory (DFT) calculations show that in general the HOMOs are mainly localized on the iridium centers, the cyclometalating phenyl moieties and the central hydrazide components of the bridging ligands, while the LUMOs are primarily localized on the N-heterocycles (pyridine or pyrazole) of the cyclometalating ligands. This series of complexes, especially with the separated diastereomers, provides an ideal opportunity to study the effects of subtle structural changes on the optoelectronic properties of diiridium systems: significant differences are observed between the rac and meso isomers in some cases. A cyclic voltammetric study of the electrochemical properties of the eight complexes reveals strong intramolecular interactions between the iridium centers. The photophysical properties are reported in solution, and in rigid poly(methyl methacrylate) (PMMA) or 2-methyltetrahydrofuran (2-MeTHF) (at 77 K) matrices where some of the complexes are strongly emissive in the turquoise and green regions (Φ PL 42-68 ±10%) due to matrix-induced restricted intramolecular motion (RIM).

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Section: Synthesissupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Synthesis, Diastereomer Separation, and Optoelectronic and Structural Properties of Dinuclear Cyclometalated Iridium(III) Complexes with Bridging Diarylhydrazide Ligands

et al. 2017

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“…In the non-covalent mechanism, no structural change of the probe occurs in the presence of the target analyte. Instead, a non-covalent interaction between the probe and the analyte changes the local environment of the probe, triggering a luminescence response [41,42]. In contrast, in the covalent mechanism, a chemical reaction takes place between a functional group on the sensing probe and the target analyte [43,44], producing novel products with different optical properties, such as wavelength and emission intensity, compared to the starting materials [45].…”

Section: Principle Of Metal Complex-based Chemosensorsmentioning

confidence: 99%

Group 8–9 Metal-Based Luminescent Chemosensors for Protein Biomarker Detection

et al. 2018

J. Anal. Test.

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The development of transition metal complex-based luminescent chemosensors has recently aroused increasing interest for protein biomarker labelling and detection, especially for the real-time diagnosis and treatment of disease. This is owing to their unique photophysical properties, particularly their long-lived and environmentally sensitive emission, which can be easily controlled via the structural modification of ligands. In this overview, we highlight recent examples of protein biomarker detection using group 8-9 metal-based luminescent chemosensors, including the frequently employed ruthenium(II) and iridium(III) complexes. Various mechanisms and sensing modes are described and compared, and the outlook and future directions of this field are discussed as well.

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“…Considerable progress has been made by the group of Lo in developing organometallic probes capable of recognizing the presence of specific classes of proteins, and has recently been the subject of a detailed review [138]. To highlight some recent advances, a large number of fac-carbonyl Re(I) (14a-14c, Fig.…”

Section: Detection Of Proteinsmentioning

confidence: 99%

Chromo- and Fluorogenic Organometallic Sensors

Fletcher

Lagunas

2009

Topics in Organometallic Chemistry

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Compounds that change their absorption and/or emission properties in the presence of a target ion or molecule have been studied for many years as the basis for optical sensing. Within this group of compounds, a variety of organometallic complexes have been proposed for the detection of a wide range of analytes such as cations (including H + ), anions, gases (e.g. O 2 , SO 2 , organic vapours), small organic molecules, and large biomolecules (e.g. proteins, DNA). This chapter focuses on work reported within the last few years in the area of organometallic sensors. Some of the most extensively studied systems incorporate metal moieties with intense long-lived metal-to-ligand charge transfer (MLCT) excited states as the reporter or indicator unit, such as fac-tricarbonyl Re(I) complexes, cyclometallated Ir(III) species, and diimine Ru(II) or Os(II) derivatives. Other commonly used organometallic sensors are based on Pt-alkynyls and ferrocene fragments. To these reporters, an appropriate recognition or analyte-binding unit is usually attached so that a detectable modification on the colour and/or the emission of the complex occurs upon binding of the analyte. Examples of recognition sites include macrocycles for the binding of cations, H-bonding units selective to specific anions, and DNA intercalating fragments. A different approach is used for the detection of some gases or vapours, where the sensor's response is associated with changes in the crystal packing of the complex on absorption of the gas, or to direct coordination of the analyte to the metal centre.

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Non-covalent binding of luminescent transition metal polypyridine complexes to avidin, indole-binding proteins and estrogen receptors

Cited by 132 publications

References 120 publications

Synthesis, Diastereomer Separation, and Optoelectronic and Structural Properties of Dinuclear Cyclometalated Iridium(III) Complexes with Bridging Diarylhydrazide Ligands

Synthesis, Diastereomer Separation, and Optoelectronic and Structural Properties of Dinuclear Cyclometalated Iridium(III) Complexes with Bridging Diarylhydrazide Ligands

Group 8–9 Metal-Based Luminescent Chemosensors for Protein Biomarker Detection

Chromo- and Fluorogenic Organometallic Sensors

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