Non-covalent and semi-covalent molecularly imprinted polymers for selective on-line solid-phase extraction of 4-nitrophenol from water samples

Caro, Ester; Masqué, N.; Marcé, Rosa María; Borrull, Francesc; Cormack, Peter A. G.; Sherrington, David C.

doi:10.1016/s0021-9673(02)00360-6

Cited by 157 publications

(58 citation statements)

References 27 publications

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“…7 Molecularly imprinted polymers can be prepared following three different imprinting approaches. 8,9 The non-covalent procedure is the most widely used, because it is relatively simple experimentally and the complexation step during the synthesis is achieved by mixing the template with an appropriate functional monomer, or monomers, Vol. 19, No.…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted sol-gel silica for solid phase extraction of phenobarbital

Pilau¹,

Silva²,

Jardim³

et al. 2008

J. Braz. Chem. Soc.

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Sílica organicamente modificada e molecularmente impressa foi preparada através de um procedimento sol-gel simples, e avaliada como sorvente específico para extração em fase sólida (Solid Phase Extraction, SPE) de fenobarbital em amostras aquosas e forenses. As propriedades analíticas dessa sílica molecularmente impressa (MIS, molecularly imprinted silica) foram inicialmente avaliadas e o material determinado como específico para as espécies-alvo: o fator de impressão IF, medido como a razão entre o pico do fenobarbital em cromatogramas de MIS e NIS (sílica não-impressa) foi estimado como 58. Este valor é consideravelmente maior que aquele apresentado normalmente para sorventes de impressão convencional baseados em metacrilatos e sugere que interações não-específicas analito/sorvente são insignificantes no MIS. O material foi aplicado no isolamento de fenobarbital de amostras aquosas e plasma; limites de detecção de 10 e 62 µg mL -1 , respectivamente, foram encontrados para essas amostras.A molecularly imprinted organically modified silica was prepared through a simple sol-gel procedure, and evaluated as specific sorbent for solid-phase extraction (SPE) of phenobarbital from aqueous and forensic samples. The analytical properties of the molecularly imprinted silica (MIS, non-imprinted sílica) were initially evaluated and the MIS was found to be specific towards the target species: the imprinting factor IF, measured as the ratio between phenobarbital peak areas in the MIS and NIS chromatograms, was estimated as 58. This value is considerably higher than those usually found for conventional methacrylate-based molecularly imprinted sorbents and suggests that non-specific analyte/sorbent interactions are insignificant in the MIS. This material is applied to the isolation of phenobarbital from aqueous samples and plasma; detection limit of 10 and 62 µg mL -1 was achieved for the former samples, respectively. Keywords: molecularly imprinted silica, sol-gel, ormosils, phenobarbital, SPE IntroductionThere is a demand for sensitive, accurate and simple analytical procedures. One of the tools to achieve these goals is the incorporation of biomolecules and biologicallike processes in the methodologies. However, despite of the specificity achieved on these procedures, natural biomolecules usually are expensive and chemically unstable. Synthetic materials such as molecularly imprinted polymers (MIP) are valid alternatives to these biological matrices. Molecular imprinting was proposed by Pauling 1 as a possible mechanism for the production of antibodies by living systems. According to his model, the synthesis of antibodies was based on the use of the aggressor chemical molecules as templates. Weak intermolecular forces such as hydrogen bonding or van der Waals forces drove proper monomer units to organize themselves around the antigen. Polymerization of the organized monomers and removal of the template would render macromolecules with cavities where the template or other species with similar structure could be highly select...

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Section: Introductionmentioning

confidence: 99%

Molecularly imprinted sol-gel silica for solid phase extraction of phenobarbital

Pilau¹,

Silva²,

Jardim³

et al. 2008

J. Braz. Chem. Soc.

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“…MIPs can be synthesized following three different imprinting approaches named covalent, non-covalent and semi-covalent procedure, according to the kind of interaction between a template and functional groups during the synthesis and recognition phases (Caro et al, 2002).…”

Section: Molecularly Imprinted Polymers (Mips): Highly Selective Matementioning

confidence: 99%

Carbon Nanotubes – Imprinted Polymers: Hybrid Materials for Analytical Applications

Cirillo¹,

Hampel²,

Puoci³

et al. 2012

Materials Science and Technology

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“…The synthesized polymers were easily hydrolyzed to form the carboxylated polymer derivatives [8][9][10]. These polymers showed an imprint effect and could be employed e.g.…”

Section: Introductionmentioning

confidence: 99%

Selective Recognition of Bifunctional Molecules by Synthetic Polymers Prepared by Covalent Molecular Imprinting

Dubey¹,

Chianella²,

Dubey³

et al. 2012

TOACJ

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Affinity polymeric adsorbents useful for the separation of compounds which are derivatives of phenols, heterocycles and other compounds containing two polar moieties were prepared by a covalent imprinting approach. Such separation, for example, would facilitate the analytical detection and quantification of each individual compound especially when present in complex sample matrix. The synthetic method, utilised for the preparation of the polymers, is based on co-polymerization of diacrylate esters of hydroxyphenols (catechol, resorcinol and hydroquinone) with an appropriate cross-linker followed by alkaline hydrolysis of the esters and release of the corresponding phenol. The resulting swellable materials contain cavities with adjustable size and orientation of two carboxylic groups suited for the binding of molecules with appropriate size and complementary orientation of polar groups. In contrast to conventional MIPs the synthesized polymers have selectivity not only for the phenolic templates, but also for a group of compounds with suitable orientations of polar functionalities, such as aromatic nitrogen, amino or hydroxyl groups. Polymers demonstrated different affinity to ortho-, meta-and para-isomers of hydroxyphenols, hydroxypyridines and diazine heterocycles.

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Non-covalent and semi-covalent molecularly imprinted polymers for selective on-line solid-phase extraction of 4-nitrophenol from water samples

Cited by 157 publications

References 27 publications

Molecularly imprinted sol-gel silica for solid phase extraction of phenobarbital

Molecularly imprinted sol-gel silica for solid phase extraction of phenobarbital

Carbon Nanotubes – Imprinted Polymers: Hybrid Materials for Analytical Applications

Selective Recognition of Bifunctional Molecules by Synthetic Polymers Prepared by Covalent Molecular Imprinting

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