Non-Covalent Adducts of Sodium Poly(α,L-glutamate) with Poly(N-vinyl pyrrolidone): Methods of Preparation and Characterization of Structure

Pemawansa, Kariyawasam P.; Khan, Ishrat M.

doi:10.1002/1616-5195(20020501)2:4<170::aid-mabi170>3.0.co;2-a

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Highly hydrophilic, nontoxic and nonimmunogenic poly‐N‐vinylpyrrolidone (PVP) is widely used in pharmaceutical and medical industries 30–35. Recent research activities also demonstrate interest in modified PVP, for example, end‐functionalized oligomers that can react with other materials to form useful biomatrices,36 as well as noncovalent complexes of PVP with biologically active peptides 37. Some of such copolymers were successfully explored for different biomedical purposes 38–43.…”

Section: Introductionmentioning

confidence: 99%

Development of multifunctional polymer–mineral composite materials for bone tissue engineering

Влах

Panarin

Tennikova

et al. 2005

J Biomedical Materials Res

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The main goal of this article is the development of a novel approach to construct multifunctional composite scaffolds for bone tissue engineering. For this purpose, different kinds of mineral macroporous supports, water-soluble aldehyde-containing copolymers of N-vinylpyrrolidone, as well as different nonspecific and biospecific ligands governing cell adhesion and growth have been used. The composite materials were tested initially for cytotoxicity in cell culture experiments using a model cell line.

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Section: Introductionmentioning

confidence: 99%

Development of multifunctional polymer–mineral composite materials for bone tissue engineering

Влах

Panarin

Tennikova

et al. 2005

J Biomedical Materials Res

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Water Soluble and Water Stable Non‐Covalent Adducts of Sodium Poly(α,L‐glutamate)/Poly(ethylene glycol). Method of Preparation and Characterization of Structure

Pemawansa

Khan

2006

Journal of Macromolecular Science, Part A

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Non-covalent nano-adducts of co-poly(ester amide) and poly(ethylene glycol): preparation, characterization and model drug-release studies

Legashvili

Nepharidze

Katsarava

et al. 2007

Journal of Biomaterials Science, Polymer Edition

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Biodegradable, biocompatible poly(ester amide)s (co-PEAs), composed of amino acids, fatty diols and carboxylic acids, have been synthesized. To improve the performance of co-PEAs in Federal Drug Administration-approved solvents such as water and ethanol, these polymers were complexed with poly(ethylene glycol) (PEG) of 10 kDa molecular mass have been prepared by solution blending. The non-covalent adducts were purified by precipitation into hexanes. Co-PEAs are soluble in organic solvents but are insoluble in water and ethanol; however, the co-PEA/PEG (0.8:1, w/w) adducts are soluble in ethanol and slightly soluble in water. 2D-NOESY NMR spectroscopy suggests that the non-covalent adducts are held together by multiple non-covalent interactions between the -CH2- groups of the two polymers (co-PEA and PEG). Differential scanning calorimetry studies indicate that the two polymers are interacting in the non-covalent adducts; the thermal properties of the adducts are different from those of the pure polymers. The solid-state adduct structures have been determined by atomic force microscopy (AFM). By one sample preparation method, nanoscale pancake-like structures were observed with an average diameter of 260 nm and an average height of 16 nm. Films of co-PEAs and (co-PEA)/PEG adducts containing Rhodamine B Base (RhBB), a model hydrophobic drug, were prepared. From the adduct/RhBB film containing 3% RhBB, 20% of the total RhBB was released within the first 2 h. Film and adduct composition may be varied to obtain different release profiles. The studies reported here demonstrate that non-covalent conjugation is a relatively easy and effective approach in developing new materials for application as biomaterials.

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Non-Covalent Adducts of Sodium Poly(α,L-glutamate) with Poly(N-vinyl pyrrolidone): Methods of Preparation and Characterization of Structure

Cited by 3 publications

References 10 publications

Development of multifunctional polymer–mineral composite materials for bone tissue engineering

Development of multifunctional polymer–mineral composite materials for bone tissue engineering

Water Soluble and Water Stable Non‐Covalent Adducts of Sodium Poly(α,L‐glutamate)/Poly(ethylene glycol). Method of Preparation and Characterization of Structure

Non-covalent nano-adducts of co-poly(ester amide) and poly(ethylene glycol): preparation, characterization and model drug-release studies

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