Non-correlation between CRP and rapid diagnostic tests for malaria among rural population in Southern Uganda (Original research paper)

Silhar, B.; Dorko, D.; Bujdova, N.; Spanik, S.; Polonova, J.; Krcmery, V.; Suvada, J.

doi:10.22359/cswhi_8_3_06

CSWHI

2017

DOI: 10.22359/cswhi_8_3_06

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Non-correlation between CRP and rapid diagnostic tests for malaria among rural population in Southern Uganda (Original research paper)

B. Silhar¹,

D. Dorko²,

N. Bujdova³

et al.

Abstract: Abstract:The correlation between CRP blood levels and clinical presentation of malaria or blood parasitemia diagnosed microscopically or by PCR is one of the most discussed topics in the field of tropical medicine and malaria diagnostics. In total, 650 patients from the Lake Victoria area,

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C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis

Wilairatana

Mahannop

Tussato

et al. 2021

Sci Rep

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This study investigated whether C-reactive protein (CRP) can be used as a marker for the early detection and monitoring of malaria severity. Potentially relevant studies were searched in Medline (PubMed), Scopus, and Web of Science. Differences in CRP between (1) severe malaria and uncomplicated malaria, (2) uncomplicated malaria and asymptomatic malaria, (3) uncomplicated malaria and febrile/healthy controls, and (4) asymptomatic malaria and febrile/healthy controls were estimated using random-effects models. Twenty-nine studies were included for meta-analysis. The results of meta-analysis demonstrated higher mean CRP levels in (1) patients with severe malaria compared with uncomplicated malaria (p < 0.001, standard mean difference [SMD]: 1.52, 95% confidence interval [CI]: 0.91–2.12, I2: 95.1%), (2) patients with uncomplicated malaria than in those with asymptomatic malaria (p: 0.001, SMD: 1.65, 95% CI: 0.67–2.62, I2: 96.7%), (3) patients with uncomplicated malaria compared with febrile/healthy controls (p < 0.001, SMD: 2.38, 95% CI: 1.37–3.40, I2: 98.5%), and (4) patients with asymptomatic malaria compared with febrile/healthy controls (p < 0.001, SMD: 2.55, 95% CI: 1.60–3.50, I2: 99.2%). This study demonstrated CRP levels are a biomarker for the early detection and monitoring of malaria severity.

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C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis

Wilairatana

Mahannop

Tussato

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

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Non-correlation between CRP and rapid diagnostic tests for malaria among rural population in Southern Uganda (Original research paper)

Abstract: Abstract:The correlation between CRP blood levels and clinical presentation of malaria or blood parasitemia diagnosed microscopically or by PCR is one of the most discussed topics in the field of tropical medicine and malaria diagnostics. In total, 650 patients from the Lake Victoria area,

Cited by 1 publication

References 1 publication

C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis

C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis

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