Non-contrast magnetic resonance lymphography (NCMRL) in cancer-related secondary lymphedema: acquisition technique and imaging findings

Background This paper offers an assessment of diagnostic tools in the evaluation of Intrahepatic Cholangiocarcinoma (ICC). Methods Several electronic datasets were analysed to search papers on morphological and functional evaluation in ICC patients. Papers published in English language has been scheduled from January 2010 to December 2021. Results We found that 88 clinical studies satisfied our research criteria. Several functional parameters and morphological elements allow a truthful ICC diagnosis. The contrast medium evaluation, during the different phases of contrast studies, support the recognition of several distinctive features of ICC. The imaging tool to employed and the type of contrast medium in magnetic resonance imaging, extracellular or hepatobiliary, should change considering patient, departement, and regional features. Also, Radiomics is an emerging area in the evaluation of ICCs. Post treatment studies are required to evaluate the efficacy and the safety of therapies so as the patient surveillance. Conclusions Several morphological and functional data obtained during Imaging studies allow a truthful ICC diagnosis.

show abstract

“…MRI is the more suitable tool in the assessment of FLL, thanks to its possibility to analyse functional and morphological data [ 102 – 115 ].…”

Section: Discussionmentioning

confidence: 99%

Conventional, functional and radiomics assessment for intrahepatic cholangiocarcinoma

Granata

Fusco

Belli

et al. 2022

Infect Agents Cancer

View full text Add to dashboard Cite

show abstract

“…The results obtained in the present study show that TA applied to ADC maps could help to assess clinical and pathological response in LARC. In a previous study, significant findings in the response assessment were found about kurtosis, based on the T2-weighted dataset of images [ 92 , 93 , 94 ]. The authors found a significantly lower kurtosis in pre-treatment TA of pCR, with significant changes after CRT.…”

Section: Discussionmentioning

confidence: 99%

Ability of Delta Radiomics to Predict a Complete Pathological Response in Patients with Loco-Regional Rectal Cancer Addressed to Neoadjuvant Chemo-Radiation and Surgery

Nardone

Reginelli

Grassi

et al. 2022

Cancers

View full text Add to dashboard Cite

We performed a pilot study to evaluate the use of MRI delta texture analysis (D-TA) as a methodological item able to predict the frequency of complete pathological responses and, consequently, the outcome of patients with locally advanced rectal cancer addressed to neoadjuvant chemoradiotherapy (C-RT) and subsequently, to radical surgery. In particular, we carried out a retrospective analysis including 100 patients with locally advanced rectal adenocarcinoma who received C-RT and then radical surgery in three different oncological institutions between January 2013 and December 2019. Our experimental design was focused on the evaluation of the gross tumor volume (GTV) at baseline and after C-RT by means of MRI, which was contoured on T2, DWI, and ADC sequences. Multiple texture parameters were extracted by using a LifeX Software, while D-TA was calculated as percentage of variations in the two time points. Both univariate and multivariate analysis (logistic regression) were, therefore, carried out in order to correlate the above-mentioned TA parameters with the frequency of pathological responses in the examined patients’ population focusing on the detection of complete pathological response (pCR, with no viable cancer cells: TRG 1) as main statistical endpoint. ROC curves were performed on three different datasets considering that on the 21 patients, only 21% achieved an actual pCR. In our training dataset series, pCR frequency significantly correlated with ADC GLCM-Entropy only, when univariate and binary logistic analysis were performed (AUC for pCR was 0.87). A confirmative binary logistic regression analysis was then repeated in the two remaining validation datasets (AUC for pCR was 0.92 and 0.88, respectively). Overall, these results support the hypothesis that D-TA may have a significant predictive value in detecting the occurrence of pCR in our patient series. If confirmed in prospective and multicenter trials, these results may have a critical role in the selection of patients with locally advanced rectal cancer who may benefit form radical surgery after neoadjuvant chemoradiotherapy.

show abstract

“…However, major limitations of MRI include its cost and accessibility and the absence of currently defined diagnostic threshold criteria. Another promising approach is that of non-contrast magnetic resonance lymphography (NMRL) that visualizes lymphatic vessels (128,129) for which a partial scoring system has recently been suggested (130). However, as with any MRI-related approach, cost, required patient time for measurement, and availability are major limitations when compared with the portable hands-on methods of measurement previously discussed.…”

Section: Imaging-based Measurement Methodsmentioning

confidence: 99%

Measuring Breast Cancer-Related Lymphedema

Mayrovitz

2022

Breast Cancer

View full text Add to dashboard Cite

Breast cancer-related lymphedema (BCRL) presents as swelling in the arm, hand, trunk, or breast at varying times after completion of breast cancer treatment. The reported incidence of BCRL varies widely in part due to its dependence on the type and extent of the treatment, pre-treatment risk factors, and the criteria used to define its presence. Central to this issue are the various quantitative measures that are used to specify lymphedema thresholds for its detection and tracking over time and during treatment.The goal of this chapter is to discuss these issues and the methods available for the non-invasive quantitative assessment of BCRL. Operational principles, advantages and limitations of the various methods, their clinical history of use, and effectiveness are discussed. Covered methods include those used to assess and monitor lymphedema-related changes in tissue water at any anatomical site and also methods used to assess changes only in limbs.Note to the Reader: This chapter is part of the book Breast Cancer (ISBN: 978-0-6453320-3-2), scheduled for publication in July 2022. The book is being published by Exon Publications,

show abstract

Non-contrast magnetic resonance lymphography (NCMRL) in cancer-related secondary lymphedema: acquisition technique and imaging findings

Cited by 20 publications

References 40 publications

Conventional, functional and radiomics assessment for intrahepatic cholangiocarcinoma

Conventional, functional and radiomics assessment for intrahepatic cholangiocarcinoma

Ability of Delta Radiomics to Predict a Complete Pathological Response in Patients with Loco-Regional Rectal Cancer Addressed to Neoadjuvant Chemo-Radiation and Surgery

Measuring Breast Cancer-Related Lymphedema

Contact Info

Product

Resources

About