We report on the first successful proof-of-principle experiment to manipulate laser-matter interactions on microscales using highly ordered Si microwire arrays. The interaction of a high-contrast short-pulse laser with a flat target via periodic Si microwires yields a substantial enhancement in both the total and cutoff energies of the produced electron beam. The self-generated electric and magnetic fields behave as an electromagnetic lens that confines and guides electrons between the microwires as they acquire relativistic energies via direct laser acceleration. DOI: 10.1103/PhysRevLett.116.085002 Laser-matter interactions at relativistic intensities have exhibited many interesting physical processes. These include the acceleration of electrons [1][2][3][4], protons, and heavy ions [5][6][7], the creation of electron-positron jets [8][9][10], and attosecond pulse generation [11,12]. The investigation of ultrashort pulse lasers interacting with initially soliddensity matter has been mainly focused on flat targets, with little or no control over the interaction. Recently the focus has shifted toward using advanced targets with the aim of increasing laser beam absorption and subsequent energy partition among various plasma species. Structured interfaces including nanoparticles [13], snowflakes [14], and nanospheres [15] have been reported to enhance laser absorption and proton acceleration, and the trapping of femtosecond laser pulses of relativistic intensity deep within ordered nanowires resulted in volumetric heating of dense matter into a new ultrahot plasma regime [16]. Another proposal addressed the potential for prescribing geometrical structures on the front of a target to greatly enhance the yield of high-energy electrons while simultaneously confining the emission to narrow angular cones [17].Microengineering laser plasma interactions, at intensities above the material damage threshold, has not been extensively explored. The main reason is that the amplified short pulses are inherently preceded by nanosecond-scale pedestals [18]. This departure from an ideal pulse can substantially modify or destroy any guiding features before the arrival of the intense portion of the pulse.Laser-pulse cleaning techniques are now being employed to significantly minimize unwanted prepulse and pedestals. For example, Ti:sapphire-based short-pulse high-intensity lasers routinely use a cross-polarized wave generation technique to achieve a contrast of at least 10 10 on the nanosecond time scale [19]. The manufacturing of advanced micro-and nanostructures has been the domain of specialized scientific disciplines such as nanoelectronics [20], microfluidics [21], and photovoltaics [22]. Microstructures with features as small as 200 nm can now be easily manufactured by nonexperts using commercially available 3D direct laser writing instruments [23]. Furthermore, 3D large-scale simulations with enough spatial and temporal resolution to capture the details of the interaction are now possible thanks to recent advances in massiv...