Non-concomitant cortical structural and functional alterations in sensorimotor areas following incomplete spinal cord injury

Pan, Yu; Dou, Wei; Wang, Yueheng; Luo, Huiwen; Ge, Yunxiang; Yan, Shu-yu; Xu, Quan; Tu, Yuanyuan; Xiao, Yanqing; Wu, Qiong; Zheng, Zhuozhao; Zhao, Huanying

doi:10.4103/1673-5374.221165

Cited by 18 publications

(16 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SCI‐nonNP subjects displayed decreased rsFC between the dorsomedial prefrontal cortex and the parietal lobe indicating abnormal synchronicity between regions involved with cognitive function and multimodal integration including spatial attention (Table 3 ). Previous studies that included a variety of SCI subjects have observed both decreases and increases of connectivity in sensory and motor regions/networks (Hou, Sun, et al, 2014 , Hou, Yan, et al, 2014 , 2016 ; Min et al, 2015 ; Oni‐Orisan et al, 2016 ; Pan et al, 2017 ) and decreases of connectivity within other core networks, that is, default‐mode and salience network (Hawasli et al, 2018 ; Kaushal et al, 2017 ). Our SCI‐nonNP cohort also showed bidirectional volumetric brain changes (Table S3 ).…”

Section: Discussionmentioning

confidence: 99%

Supraspinal nociceptive networks in neuropathic pain after spinal cord injury

Huynh

Lütolf

Rösner

et al. 2021

Human Brain Mapping

View full text Add to dashboard Cite

Neuropathic pain following spinal cord injury involves plastic changes along the whole neuroaxis. Current neuroimaging studies have identified grey matter volume (GMV) and resting-state functional connectivity changes of pain processing regions related to neuropathic pain intensity in spinal cord injury subjects. However, the relationship between the underlying neural processes and pain extent, a complementary characteristic of neuropathic pain, is unknown. We therefore aimed to reveal the neural markers of widespread neuropathic pain in spinal cord injury subjects and hypothesized that those with greater pain extent will show higher GMV and stronger connectivity within pain related regions. Thus, 29 chronic paraplegic subjects and 25 healthy controls underwent clinical and electrophysiological examinations combined with neuroimaging. Paraplegics were demarcated based on neuropathic pain and were thoroughly matched demographically. Our findings indicate that (a) spinal cord injury subjects with neuropathic pain display stronger connectivity between prefrontal cortices and regions involved with sensory integration and multimodal processing, (b) greater neuropathic pain extent, is associated with stronger connectivity between the posterior insular cortex and thalamic sub-regions which partake in the lateral pain system and (c) greater intensity of neuropathic pain is related to stronger connectivity of regions involved with multimodal integration and the affective-motivational component of pain. Overall, this study provides neuroimaging evidence that the pain phenotype of spinal cord injury subjects is related to the underlying function of their resting brain.

show abstract

Section: Discussionmentioning

confidence: 99%

Supraspinal nociceptive networks in neuropathic pain after spinal cord injury

Huynh

Lütolf

Rösner

et al. 2021

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Previous research using resting-state fMRI has reported a decrease in functional connectivity (FC) between cortical sensorimotor regions after SCI. 9-15 Such alterations in resting-state properties have been shown by a previous study to hold significant implications for the prognosis of SCI at 6 months postinjury. 15 Findings from alternative approaches such as graph analysis provide evidence for preserved small-worldness with reduced local efficiency and greater network modularity and characteristic path length in the network architecture of SCI patients.…”

Section: Introductionmentioning

confidence: 69%

Resting-State Functional Connectivity of the Thalamus in Complete Spinal Cord Injury

Karunakaran

Yuan

et al. 2020

Neurorehabil Neural Repair

View full text Add to dashboard Cite

Background. Neuroimaging studies of spinal cord injury (SCI) have mostly examined the functional organization of the cortex, with only limited focus on the subcortical substrates of the injury. However, thalamus is an important modulator and sensory relay that requires investigation at a subnuclei level to gain insight into the neuroplasticity following SCI. Objective. To use resting-state functional magnetic resonance imaging to examine the functional connectivity (FC) of thalamic subnuclei in complete SCI patients. Methods. A seed-based connectivity analysis was applied for 3 thalamic subnuclei: pulvinar, mediodorsal, and ventrolateral nucleus in each hemisphere. A nonparametric 2-sample t test with permutations was applied for each of the 6 thalamic seeds to compute FC differences between 22 healthy controls and 19 complete SCI patients with paraplegia. Results. Connectivity analysis showed a decrease in the FC of the bilateral mediodorsal nucleus with right superior temporal gyrus and anterior cingulate cortex in the SCI group. Similarly, the left ventrolateral nucleus exhibited decreased FC with left superior temporal gyrus in SCI group. In contrast, left pulvinar nucleus demonstrated an increase in FC with left inferior frontal gyrus and left inferior parietal lobule in SCI group. Our findings also indicate a negative relationship between postinjury durations and thalamic FC to regions of sensorimotor and visual cortices, where longer postinjury durations (~12 months) is associated with higher negative connectivity between these regions. Conclusion. This study provides evidence for reorganization in the thalamocortical connections known to be involved in multisensory integration and affective processing, with possible implications in the generation of sensory abnormalities after SCI.

show abstract

“…To date, knowledge regarding the function of lncRNAs mediated by ROCK in HCC is lacking. ROCK proteins have been shown to modulate proliferation by affecting lncRNAs, such as lncRNA – Six1 [27] and NONMMUG014387 [28]. However, these regulations have not been illustrated via protein-lncRNA interactions.…”

Section: Discussionmentioning

confidence: 99%

Overlapping and unique roles played by ROCK1 and 2 in the modulation of coding and long noncoding RNA expression

Zhang

et al. 2019

BMC Genomics

View full text Add to dashboard Cite

Background Our previous study described the crucial role of Rho-associated coiled-coil containing-kinases (ROCK) in hepatocellular carcinoma (HCC). However, the potential significance of long noncoding RNA downstream of ROCK is largely unknown. Here, a comprehensive comparative bioinformatics analysis of a microarray of an MHCC-97H cell line overexpressing ROCK1 or ROCK2 was performed. Results Numerous lncRNAs and mRNAs were deregulated by Rho-associated coiled-coil containing kinases 1 and 2. These results were consistent with the qRT-PCR results. Compared with MHCC-97H-Con, which was transfected with a null vector, the GO analysis revealed differentially expressed mRNAs (DEmRNAs) in MHCC-97H-ROCK1 (ROCK1 was overexpressed) enriched in apoptotic cell clearance, the cyclooxygenase pathway and bone trabecula morphogenesis; the DEmRNAs in MHCC-97H-ROCK2 (ROCK2 was overexpressed) were enriched in VEGF production, chemokine-associated signaling pathways, acute inflammatory response and vasoconstriction. Compared with MHCC-97H-ROCK2, the DEmRNAs in MHCC-97H-ROCK1 were involved in the JAK-STAT cascade, the Akt signaling pathway and the activity of several different peptidases. The pathway analysis of ROCK1 and ROCK2 revealed an overlap in the VEGF signaling pathway, ECM-receptor interaction, and adhesion and differences in the PPAR signaling pathway and mismatch repair. The predicted targets of the differentially expressed lncRNA (DElncRNAs) were enriched in the p53 signaling pathway, Jak-STAT signaling pathway, etc. Several hub DElncRNAs were identified. Conclusions ROCK1 and 2 modulate the expression of numerous mRNAs and lncRNAs and may participate in several signaling pathways in HCC. Several hub molecules were identified in the lncRNA-mRNA networks. Our results provide baseline data for ROCK1 and 2 regulation in HCC that might have implications for further research. Electronic supplementary material The online version of this article (10.1186/s12864-019-5715-0) contains supplementary material, which is available to authorized users.

show abstract

Non-concomitant cortical structural and functional alterations in sensorimotor areas following incomplete spinal cord injury

Cited by 18 publications

References 51 publications

Supraspinal nociceptive networks in neuropathic pain after spinal cord injury

Supraspinal nociceptive networks in neuropathic pain after spinal cord injury

Resting-State Functional Connectivity of the Thalamus in Complete Spinal Cord Injury

Overlapping and unique roles played by ROCK1 and 2 in the modulation of coding and long noncoding RNA expression

Contact Info

Product

Resources

About