Given a von Neumann algebra M with a faithful normal semi-finite trace τ, let L(M, τ ) be the algebra of all τ -measurable operators affiliated with M. We prove that if A is a locally convex reflexive complete metrizable solid * -subalgebra in L(M, τ ), which can be embedded into a locally bounded weak Fréchet Mbimodule, then any derivation on A is inner.