Non-Communicable Chronic Diseases: The Role of Neonatal Characteristics

Martire, Baldassarre; Mauro, Antônio Orlando Di; Cintoli, Annarita; Mincarone, Giuseppina; Tafuri, Silvio; Laforgia, Nicola

doi:10.5812/ijp.9322

Cited by 6 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is a significantly higher prevalence in comparison to other European studies on children born at term, in which around 30% of children had EAR [2,16]. This high prevalence of EAR is significantly related to higher BMI at seven years of age and may possibly increase the risk of obesity and other non-communicable diseases in adulthood [17], as previously stated in a recent systematic review and meta-analysis in which childhood obesity was found to be a predictor of morbidity in adulthood [18].…”

Section: Discussionmentioning

confidence: 56%

Premature Birth is an Independent Risk Factor for Early Adiposity Rebound: Longitudinal Analysis of BMI Data from Birth to 7 Years

et al. 2020

Self Cite

View full text Add to dashboard Cite

Adiposity rebound (AR) refers to the second rise of the body mass index (BMI) curve that usually occurs physiologically between five and seven years of age. AR timing has a great impact on patients’ health, since early adiposity rebound (EAR) is associated with the development of metabolic syndrome later in life. We aimed to investigate the prevalence of EAR in a cohort of inborn preterm infants admitted to the Neonatal Intensive Care Section of the Policlinico University Hospital of Bari, Italy. Secondarily, we assessed whether some determinants such as (1) gender; (2) delivery mode; (3) birth weight and classification into small, normal, or large for gestational age; (4) type of feeding; (5) breastfeeding duration; (6) timing of introduction of solid food; (7) parental education; and (8) parental pre-pregnancy body mass index (BMI) influenced EAR in this cohort. The tertiary aim was to evaluate the prevalence of obesity or being overweight at seven years of age in children according to early versus timely AR. This is a prospective, population-based longitudinal study conducted at the Neonatal Intensive Care Section of the Policlinico University Hospital of Bari, Italy. Inborn preterm infants admitted to the neonatal ward between 2009 and 2011 were eligible. Enrolled preterm infants were evaluated at birth and at 1, 3, 6, 9, 12, 15, 18, and 24 months and 3, 4, 5, 6, and 7 years of age. Weight and height data were analyzed, and BMI was calculated. AR was assessed in the growth trajectory in a body mass index (BMI) plot. Of the 250 preterm newborns included, 100 completed the seven-year follow-up and entered the final analysis, 138 were lost during the seven-year follow-up, and in 12 cases parents withdrew over the course of the study. The prevalence of EAR in our cohort of preterm newborns was 54% at seven years of age. Early adiposity rebound was associated with being large for gestational age (LGA) at birth. No other factors were associated with EAR. Early adiposity rebounders had a significantly higher BMI at seven years compared to children with timely AR (17.2 ± 2.7 vs. 15.6 ± 2.05, p = 0.021). No significant differences were found in the prevalence of obesity or being overweight at seven years of age in children with early or timely AR (29% vs. 14%, p = 0.202). Ex-preterm infants have an increased risk of EAR. Since EAR may lead to long-term detrimental health effects with the onset of various chronic diseases (e.g., obesity, metabolic syndrome, etc.), healthcare providers should be prepared to counteract its occurrence, especially in delicate sub-populations of infants.

show abstract

Section: Discussionmentioning

confidence: 56%

Premature Birth is an Independent Risk Factor for Early Adiposity Rebound: Longitudinal Analysis of BMI Data from Birth to 7 Years

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, other available data speculate that neonatal colonization contributes to other short- and long-term sequelae of prematurity, such as respiratory distress and bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP) [67], somatic growth in early life, and cardiovascular and other non-communicable chronic diseases later in adulthood [68,69,70].…”

Section: Neonatal Dysbiosis and Consequences For The Premature Infmentioning

confidence: 99%

Dysbiosis and Prematurity: Is There a Role for Probiotics?

et al. 2019

Self Cite

View full text Add to dashboard Cite

Healthy microbiota is a critical mediator in maintaining health and it is supposed that dysbiosis could have a role in the pathogenesis of a number of diseases. Evidence supports the hypothesis that maternal dysbiosis could act as a trigger for preterm birth; aberrant colonization of preterm infant gut might have a role in feeding intolerance and pathogenesis of necrotizing enterocolitis. Despite several clinical trials and meta-analyses, it is still not clear if modulation of maternal and neonatal microbiota with probiotic supplementation decreases the risk of preterm birth and its complications.

show abstract

“…Afterwards, in childhood food preferences are formed and are tracked into childhood and beyond, and foundations are laid for a healthy adult life. 15 In our cohort, none of the investigated neonatal factors were associated to EAR. EAR in our cohort was not associated to gender, despite female obesity susceptibilities is a well-known phenomenon.…”

Section: Discussionmentioning

confidence: 55%

Timing of Complementary Feeding in Preterm Infants is not Associated with Early Adiposity Rebound: Longitudinal Analysis of BMI Data from Birth to 7 Years

Martire¹,

Mauro²,

Caroli³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Adiposity rebound (AR) refers to the second rise of the BMI curve that usually occurs physiologically between 5 and 7 years of age. AR timing has a great impact on children´s health, being the early adiposity rebound (EAR) associated with the development of metabolic disease later in life. Aim: We aimed to investigate the prevalence of EAR in a cohort of preterm newborns. Secondary outcomes evaluated if some determinants such as (1) gender (male/female), (2) type of delivery (caesarean/vaginal), (3) birth weight (SGA/NGA/LGA), (4) type of feeding (5) duration of breastfeeding, (6) timing of introduction of solid food, (7) parental education and (8) parental pre-pregnancy BMI can influence EAR in this cohort. Tertiary aim was to evaluate the prevalence of obesity or overweight at 7 years of age in children according to early versus timely AR. Methods: This is a perspective, population-based longitudinal study, where infants born preterm were evaluated at birth and at 1, 3, 6, 9, 12, 15, 18, 24 months and 3, 4, 5, 6, 7 years of gestational-corrected age. Weight and height data were analyzed, and BMI was calculated. AR was assessed in the growth trajectory in a body mass index (BMI) plot. Results: Of the 250 preterm newborns included, 100 completed the 7 years follow-up and entered in the final analysis. The prevalence of EAR in our cohort of preterm newborns was 54%. EAR was associated with being LGA at birth. No other factors were associated to EAR. Early adiposity rebounders have a significant higher BMI at 7 years compared to children with timely AR (17.2 ±2.7 vs 15.6 ± 2.05, p=0.021). No significant differences were found in the prevalence of obesity or overweight at 7 years of age in children with early or timely AR (29% vs 14% p=0.202). Conclusions: Clinical management of preterm infants should focus on reducing excess weight gain to prevent long-term metabolic risk. Others neonatal factors are not associated to an higher risk of EAR.

show abstract

Non-Communicable Chronic Diseases: The Role of Neonatal Characteristics

Cited by 6 publications

References 21 publications

Premature Birth is an Independent Risk Factor for Early Adiposity Rebound: Longitudinal Analysis of BMI Data from Birth to 7 Years

Premature Birth is an Independent Risk Factor for Early Adiposity Rebound: Longitudinal Analysis of BMI Data from Birth to 7 Years

Dysbiosis and Prematurity: Is There a Role for Probiotics?

Timing of Complementary Feeding in Preterm Infants is not Associated with Early Adiposity Rebound: Longitudinal Analysis of BMI Data from Birth to 7 Years

Contact Info

Product

Resources

About