Non-coding variants impactcis-regulatory coordination in a cell type-specific manner
Olga Pushkarev,
Guido van Mierlo,
Judith F. Kribelbauer
et al.
Abstract:Interactions among cis-regulatory elements (CREs) play a crucial role in gene regulation. Various approaches have been developed to map these interactions genome-wide, including those relying on interindividual epigenomic variation to identify groups of covariable regulatory elements, referred to as chromatin modules (CMs). While CM mapping allows to investigate the relationship between chromatin modularity and gene expression, the computational principles used for CM identification vary in their application a… Show more
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